ENSMUSG00000040943


Mus musculus

Features
Gene ID: ENSMUSG00000040943
  
Biological name :Tet2
  
Synonyms : Mus musculus tet methylcytosine dioxygenase 2 (Tet2), transcript variant 2, mRNA. / Q4JK59 / Tet2
  
Possible biological names infered from orthology : Q6N021 / tet methylcytosine dioxygenase 2
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: G3
Gene start: 133463679
Gene end: 133545139
  
Corresponding Affymetrix probe sets: 10502284 (MoGene1.0st)   1438781_at (Mouse Genome 430 2.0 Array)   1455300_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143468
Ensembl peptide - ENSMUSP00000143619
Ensembl peptide - ENSMUSP00000096203
Ensembl peptide - ENSMUSP00000143029
NCBI entrez gene - 214133     See in Manteia.
MGI - MGI:2443298
RefSeq - XM_011240068
RefSeq - NM_001040400
RefSeq - NM_001346736
RefSeq - XM_006501281
RefSeq - XM_006501283
RefSeq - XM_006501286
RefSeq - XM_006501287
RefSeq Peptide - NP_001035490
RefSeq Peptide - NP_001333665
swissprot - A0A0G2JGM1
swissprot - A0A0G2JG87
swissprot - Q4JK59
swissprot - A0A0G2JF55
Ensembl - ENSMUSG00000040943
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tet2ENSDARG00000076928Danio rerio
 TET2ENSGALG00000010592Gallus gallus
 TET2ENSG00000168769Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tet3 / Q8BG87 / Mus musculus tet methylcytosine dioxygenase 3 (Tet3), transcript variant 1, mRNA. / O43151* / tet methylcytosine dioxygenase 3*ENSMUSG0000003483223
Tet1 / Q3URK3 / tet methylcytosine dioxygenase 1 / Q8NFU7*ENSMUSG0000004714619
Cxxc4 / Q6NXI8 / CXXC-type zinc finger protein 4 / CXXC finger protein 4*ENSMUSG000000443653
Cxxc5 / Q91WA4 / Mus musculus CXXC finger 5 (Cxxc5), transcript variant 2, mRNA. / Q7LFL8* / CXXC finger protein 5*ENSMUSG000000466682


Protein motifs (from Interpro)
Interpro ID Name
 IPR024779  2OGFeDO, oxygenase domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0002318 myeloid progenitor cell differentiation IMP
 biological_processGO:0006211 5-methylcytosine catabolic process IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006493 protein O-linked glycosylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0019857 5-methylcytosine metabolic process IMP
 biological_processGO:0019858 cytosine metabolic process IMP
 biological_processGO:0020027 hemoglobin metabolic process IMP
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0030099 myeloid cell differentiation IEA
 biological_processGO:0035511 oxidative DNA demethylation TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048536 spleen development IMP
 biological_processGO:0048872 homeostasis of number of cells IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0061484 hematopoietic stem cell homeostasis IMP
 biological_processGO:0072576 liver morphogenesis IMP
 biological_processGO:0080111 DNA demethylation IEA
 biological_processGO:0080182 histone H3-K4 trimethylation IEA
 cellular_componentGO:0005634 nucleus IC
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0008198 ferrous iron binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0070579 methylcytosine dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tspyl2tm1Sich/Tspyl2tm1Sich
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2Gt(AN0709)Wtsi
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2+
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2tm1Ics/Tet2tm1Ics,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tet2tm1.1Mjxu/Tet2tm1.1Mjxu
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Tet2tm1.1Mjxu/Tet2+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tet2tm1.1Mjxu/Tet2tm1.1Mjxu
Genetic Background: involves: 129 * C57BL/6

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tspyl2tm1Sich/Tspyl2tm1Sich
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2Gt(AN0709)Wtsi
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2+
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2tm1Ics/Tet2tm1Ics,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tet2tm1.1Mjxu/Tet2tm1.1Mjxu
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Tet2tm1.1Mjxu/Tet2+
Genetic Background: involves: 129 * C57BL/6

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tspyl2tm1Sich/Tspyl2tm1Sich
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2Gt(AN0709)Wtsi
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2tm1Ics/Tet2tm1Ics,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Tspyl2tm1Sich/Tspyl2tm1Sich
Genetic Background: involves: 129S/SvEv

Allelic Composition: Sf3b1tm1.1Mdf/Sf3b1+,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J

 MP:0000248 macrocytosis "condition in which erythrocytes are larger than normal in size" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sf3b1tm1.1Mdf/Sf3b1+,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Tet2tm1.2Rao/Tet2tm1.2Rao
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Tet2tm1.1Mjxu/Tet2tm1.1Mjxu
Genetic Background: involves: 129 * C57BL/6

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tspyl2tm1Sich/Tspyl2tm1Sich
Genetic Background: involves: 129S/SvEv

Allelic Composition: Sf3b1tm1.1Mdf/Sf3b1+,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2Gt(AN0709)Wtsi
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2+
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2tm1Ics/Tet2tm1Ics,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tet2tm1.1Mjxu/Tet2tm1.1Mjxu
Genetic Background: involves: 129 * C57BL/6

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2Gt(AN0709)Wtsi
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2+
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2tm1Ics/Tet2tm1Ics,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tspyl2tm1Sich/Tspyl2tm1Sich
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2Gt(AN0709)Wtsi
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2+
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2tm1Ics/Tet2tm1Ics,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tet2tm1.1Mjxu/Tet2tm1.1Mjxu
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Tet2tm1.1Mjxu/Tet2+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Sf3b1tm1.1Mdf/Sf3b1+,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2Gt(AN0709)Wtsi
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2+
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2Gt(AN0709)Wtsi
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2+
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2tm1.1Mjxu/Tet2tm1.1Mjxu
Genetic Background: involves: 129 * C57BL/6

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Tspyl2tm1Sich/Tspyl2tm1Sich
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tet2tm1.2Rao/Tet2tm1.2Rao
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Asxl1tm1.1Iaai/Asxl1tm1.1Iaai,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Allelic Composition: Sf3b1tm1.1Mdf/Sf3b1+,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2Gt(AN0709)Wtsi
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2+
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Tet2tm1.1Mjxu/Tet2tm1.1Mjxu
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Tet2tm1.1Mjxu/Tet2+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129 * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tspyl2tm1Sich/Tspyl2tm1Sich
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2Gt(AN0709)Wtsi
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2+
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2tm1.1Mjxu/Tet2tm1.1Mjxu
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Tet2tm1.1Mjxu/Tet2+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Asxl1tm1.1Iaai/Asxl1tm1.1Iaai,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tet2tm1.2Rao/Tet2tm1.2Rao
Genetic Background: involves: C57BL/6NTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tspyl2tm1Sich/Tspyl2tm1Sich
Genetic Background: involves: 129S/SvEv

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tet2tm1Ics/Tet2tm1Ics,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sf3b1tm1.1Mdf/Sf3b1+,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sf3b1tm1.1Mdf/Sf3b1+,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2Gt(AN0709)Wtsi
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2+
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2tm1Ics/Tet2tm1Ics,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Tet2tm1.1Mjxu/Tet2tm1.1Mjxu
Genetic Background: involves: 129 * C57BL/6

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2Gt(AN0709)Wtsi
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2+
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2Gt(AN0709)Wtsi
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2+
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2tm1Ics/Tet2tm1Ics,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2+
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129 * C57BL/6

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tspyl2tm1Sich/Tspyl2tm1Sich
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2Gt(AN0709)Wtsi
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2tm1Ics/Tet2tm1Ics,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tet2tm1.2Rao/Tet2tm1.2Rao
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Tet2tm1.1Mjxu/Tet2tm1.1Mjxu
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Sf3b1tm1.1Mdf/Sf3b1+,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2Gt(AN0709)Wtsi
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2+
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2tm1Ics/Tet2tm1Ics,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tspyl2tm1Sich/Tspyl2tm1Sich
Genetic Background: involves: 129S/SvEv

Allelic Composition: Sf3b1tm1.1Mdf/Sf3b1+,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2Gt(AN0709)Wtsi
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2tm1Ics/Tet2tm1Ics,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0005481 chronic myelocytic leukemia "a heterogeneous group of myeloproliferative disorders that may evolve into acute leukemia in late stages " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tet2tm1.1Mjxu/Tet2tm1.1Mjxu
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Tet2tm1.1Mjxu/Tet2+
Genetic Background: involves: 129 * C57BL/6

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Tet2tm1.1Mjxu/Tet2tm1.1Mjxu
Genetic Background: involves: 129 * C57BL/6

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2Gt(AN0709)Wtsi
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2tm1Ics/Tet2tm1Ics,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Tet2tm1.1Mjxu/Tet2tm1.1Mjxu
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008112 abnormal monocyte differentiation "atypical production of or inability to produce the large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood" [CL:0000576, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2Gt(AN0709)Wtsi
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2+
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

 MP:0008208 decreased pro-B cell number "reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2Gt(AN0709)Wtsi
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2tm1Ics/Tet2tm1Ics,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2Gt(AN0709)Wtsi
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2tm1Ics/Tet2tm1Ics,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008250 abnormal myeloid leukocyte morphology "any structural anomaly of a cell of the monocyte, granulocyte, or mast cell lineage" [CL:0000766]
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Allelic Composition: Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008389 hypochromic macrocytic anemia "hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, where the erythrocyte corpuscular volume is larger than normal" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sf3b1tm1.1Mdf/Sf3b1+,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tet2tm1Ics/Tet2tm1Ics,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008801 abnormal erythroid progenitor cell morphology "any structural anomaly of a progenitor cell committed to the erythroid lineage" [CL:0000038]
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Allelic Composition: Sf3b1tm1.1Mdf/Sf3b1+,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA/J

 MP:0008989 abnormal liver sinusoid morphology "any structural anomaly of the hepatic distensible vascular blood channels lined with highly fenestrated endothelial cells that function to exchange fluids, nutrients, proteins and wastes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Tet2tm1Ics/Tet2tm1Ics,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0009338 increased splenocyte number "increase in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tet2tm1.2Rao/Tet2tm1.2Rao
Genetic Background: involves: C57BL/6NTac

 MP:0010129 increased DN1 thymic pro-T cell number "increased number of pro-T cells that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative" [CL:0000894]
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Allelic Composition: Tet2Gt(AN0709)Wtsi/Tet2Gt(AN0709)Wtsi
Genetic Background: B6.129P2-Tet2Gt(AN0709)Wtsi

Allelic Composition: Tet2tm1Ics/Tet2tm1Ics,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tet2tm1.1Mjxu/Tet2tm1.1Mjxu
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Tet2tm1.1Mjxu/Tet2+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0010639 altered tumor pathology "any changes associated with the chemistry, immunohistology, cellular alterations or environmental interactions of tumors compared to the expected state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ncstntm1.1Akli/Ncstntm1.1Akli,Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tspyl2tm1Sich/Tspyl2tm1Sich
Genetic Background: involves: 129S/SvEv

Allelic Composition: Tet2tm1.1Iaai/Tet2+,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tet2tm1.1Mjxu/Tet2tm1.1Mjxu
Genetic Background: involves: 129 * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Il21rtm1Wjl/Il21rtm1Wjl,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: involves: 129 * C57BL/6

 MP:0011178 increased erythroblast number "greater number of the nucleated precursor of erythrocytes" [MGI:csmith]
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Allelic Composition: Tet2tm1Ics/Tet2tm1Ics,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0011181 increased hematopoietic cell number "greater than expected number of cells of the hematopoietic lineage" [MGI:csmith]
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Allelic Composition: Tet2tm1.1Iaai/Tet2+,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Tet2tm1.1Iaai/Tet2tm1.1Iaai,Tg(Vav1-cre)1Graf/0
Genetic Background: involves: 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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