ENSMUSG00000047146


Mus musculus

Features
Gene ID: ENSMUSG00000047146
  
Biological name :Tet1
  
Synonyms : Q3URK3 / Tet1 / tet methylcytosine dioxygenase 1
  
Possible biological names infered from orthology : Q8NFU7
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B4
Gene start: 62804570
Gene end: 62908996
  
Corresponding Affymetrix probe sets: 10369688 (MoGene1.0st)   10369690 (MoGene1.0st)   10369702 (MoGene1.0st)   1419896_at (Mouse Genome 430 2.0 Array)   1419897_at (Mouse Genome 430 2.0 Array)   1429448_s_at (Mouse Genome 430 2.0 Array)   1455425_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000154527
Ensembl peptide - ENSMUSP00000151836
Ensembl peptide - ENSMUSP00000154690
Ensembl peptide - ENSMUSP00000059527
Ensembl peptide - ENSMUSP00000133279
Ensembl peptide - ENSMUSP00000133706
Ensembl peptide - ENSMUSP00000134328
Ensembl peptide - ENSMUSP00000134571
Ensembl peptide - ENSMUSP00000151633
NCBI entrez gene - 52463     See in Manteia.
MGI - MGI:1098693
RefSeq - XM_017314027
RefSeq - NM_001253857
RefSeq - NM_027384
RefSeq - XM_006513867
RefSeq - XM_006513869
RefSeq - XM_011243508
RefSeq - XM_011243509
RefSeq Peptide - NP_001240786
RefSeq Peptide - NP_081660
swissprot - G3UXI7
swissprot - G3UZ35
swissprot - G3UZN8
swissprot - E9Q9Y4
swissprot - Q3URK3
swissprot - A0A1W2P7E3
Ensembl - ENSMUSG00000047146
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tet1ENSDARG00000075230Danio rerio
 TET1ENSGALG00000031604Gallus gallus
 TET1ENSG00000138336Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tet3 / Q8BG87 / Mus musculus tet methylcytosine dioxygenase 3 (Tet3), transcript variant 1, mRNA. / O43151* / tet methylcytosine dioxygenase 3*ENSMUSG0000003483222
Tet2 / Q4JK59 / Mus musculus tet methylcytosine dioxygenase 2 (Tet2), transcript variant 2, mRNA. / Q6N021* / tet methylcytosine dioxygenase 2*ENSMUSG0000004094318
Cxxc4 / Q6NXI8 / CXXC-type zinc finger protein 4 / CXXC finger protein 4*ENSMUSG000000443654
Cxxc5 / Q91WA4 / Mus musculus CXXC finger 5 (Cxxc5), transcript variant 2, mRNA. / Q7LFL8* / CXXC finger protein 5*ENSMUSG000000466682


Protein motifs (from Interpro)
Interpro ID Name
 IPR002857  Zinc finger, CXXC-type
 IPR024779  2OGFeDO, oxygenase domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001826 inner cell mass cell differentiation IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006493 protein O-linked glycosylation IMP
 biological_processGO:0008284 positive regulation of cell proliferation ISS
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0031062 positive regulation of histone methylation ISO
 biological_processGO:0035511 oxidative DNA demethylation TAS
 biological_processGO:0044030 regulation of DNA methylation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0080111 DNA demethylation ISO
 biological_processGO:0090310 negative regulation of methylation-dependent chromatin silencing ISO
 biological_processGO:2000653 regulation of genetic imprinting IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0005506 iron ion binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0070579 methylcytosine dioxygenase activity TAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000108 midline facial cleft "incomplete merging or fusion of the tissues normally uniting to form the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Tg(Myh6-Rxra)41Pcn/0
Genetic Background: involves: 129S2/SvPas

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Tg(GFAP-cre)#Gtm/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA

 MP:0000372 irregular coat pigmentation "uneven coloration of the hair" [J:65030]
Show

Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Tg(Myh6-Rxra)41Pcn/0
Genetic Background: involves: 129S2/SvPas

 MP:0000823 abnormal lateral ventricle morphology "malformation or absence of cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Tg(Myh6-Rxra)41Pcn/0
Genetic Background: involves: 129S2/SvPas

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
Show

Allelic Composition: CrygbS11R/CrygbS11R,Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: A/J * C57BL/6J

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Nrxn1tm3Sud/Nrxn1tm3Sud
Genetic Background: B6.129-Nrxn1tm3Sud

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Tg(Myh6-Rxra)41Pcn/0
Genetic Background: involves: 129S2/SvPas

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Tg(Myh6-Rxra)41Pcn/0
Genetic Background: involves: 129S2/SvPas

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Tg(GFAP-cre)#Gtm/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA

 MP:0001300 ocular hypertelorism "increased distance between the eyes " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Tg(Myh6-Rxra)41Pcn/0
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Tet1tuft/Tet1tuft
Genetic Background: involves: 3H1/Lznf * BALB/c

Allelic Composition: Tet1tuft/Tet1tuft
Genetic Background: involves: 3H1/Lznf * M. m. castaneus

 MP:0001468 abnormal temporal memory "anomaly in the ability to recall temporal events and stimuli" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Tet1tm1Gxu/Tet1tm1.1Gxu,Tg(Nes-cre/ERT2)KEisc/0
Genetic Background: involves: 129 * C57BL/6J

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nrxn1tm3Sud/Nrxn1tm3Sud
Genetic Background: B6.129-Nrxn1tm3Sud

Allelic Composition: Tet1Gt(RRG140)Byg/Tet1Gt(RRG140)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001890 anencephaly "absence of the bones of the cranial vault and absent or rudimentary cerebral and cerebellar hemispheres, brainstem, and basal ganglia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:31571]
Show

Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Tg(Myh6-Rxra)41Pcn/0
Genetic Background: involves: 129S2/SvPas

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Tg(GFAP-cre)#Gtm/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Tet1Gt(RRG140)Byg/Tet1Gt(RRG140)Byg
Genetic Background: B6.129P2-Tet1Gt(RRG140)Byg

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: CrygbS11R/CrygbS11R,Gja8tm1(Gja3)Tww/Gja8tm1(Gja3)Tww
Genetic Background: involves: A/J * C57BL/6J

 MP:0003578 absent ovary "absence of the female reproductive gland containing the germ cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Tet1Gt(RRG140)Byg/Tet1Gt(RRG140)Byg
Genetic Background: B6.129P2-Tet1Gt(RRG140)Byg

 MP:0003699 abnormal female reproductive system physiology "anomaly in the function of the female organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tet1Gt(RRG140)Byg/Tet1Gt(RRG140)Byg
Genetic Background: B6.129P2-Tet1Gt(RRG140)Byg

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
Show

Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Tg(Myh6-Rxra)41Pcn/0
Genetic Background: involves: 129S2/SvPas

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Tg(GFAP-cre)#Gtm/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA

 MP:0004856 decreased ovary weight "reduction in the average weight of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tet1Gt(RRG140)Byg/Tet1Gt(RRG140)Byg
Genetic Background: B6.129P2-Tet1Gt(RRG140)Byg

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Igf2bp1tm1Vssp/Igf2bp1tm1Vssp,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: C57BL/6J * SJL

Allelic Composition: Tet1tm1Gxu/Tet1tm1.1Gxu,Tg(Nes-cre/ERT2)KEisc/0
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Tet1tm1.1Gxu/Tet1tm1.1Gxu,Tg(Nes-EGFP)33Enik/0
Genetic Background: involves: 129 * BALB/cBy * C57BL/6 * C57BL/6J

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tet1Gt(RRG140)Byg/Tet1Gt(RRG140)Byg
Genetic Background: B6.129P2-Tet1Gt(RRG140)Byg

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tet1Gt(RRG140)Byg/Tet1Gt(RRG140)Byg
Genetic Background: B6.129P2-Tet1Gt(RRG140)Byg

 MP:0008818 abnormal interfrontal bone morphology "any structural anomaly or presence of a bone between the frontal bones in the skull; an extra bony plate within the anterior fontanelle that is not usually present" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Tg(Myh6-Rxra)41Pcn/0
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Tet1tuft/Tet1tuft
Genetic Background: involves: 3H1/Lznf * BALB/c

 MP:0008845 abnormal paraventricular hypothalamic nucleus morphology "any structural anomaly of a group of magnocellular neurons located in the periventricular zone of the anterior half of the hypothalamus" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Tg(Myh6-Rxra)41Pcn/0
Genetic Background: involves: 129S2/SvPas

 MP:0008846 abnormal supraoptic nucleus morphology "any structural anomaly of a group of cells in the hypothalamus located over the lateral border of the optic tract; neurons produce and transport vasopressin" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Tg(Myh6-Rxra)41Pcn/0
Genetic Background: involves: 129S2/SvPas

 MP:0008877 abnormal DNA methylation "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
Show

Allelic Composition: Tet1tm1.1Gxu/Tet1tm1.1Gxu,Tg(Nes-EGFP)33Enik/0
Genetic Background: involves: 129 * BALB/cBy * C57BL/6 * C57BL/6J

 MP:0009452 abnormal synaptonemal complex "an anomaly in the formation of the proteinaceous structure involved in the pairing of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tet1Gt(RRG140)Byg/Tet1Gt(RRG140)Byg
Genetic Background: B6.129P2-Tet1Gt(RRG140)Byg

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nf1tm1Fcr/Nf1+,Tg(GFAP-cre)#Gtm/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Tet1Gt(RRG140)Byg/Tet1Gt(RRG140)Byg
Genetic Background: B6.129P2-Tet1Gt(RRG140)Byg

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tet1tm1Gxu/Tet1tm1.1Gxu,Tg(Nes-cre/ERT2)KEisc/0
Genetic Background: involves: 129 * C57BL/6J

 MP:0010343 increased lipoma incidence "greater than the expected number of a benign neoplasia derived from lipoblasts or lipocytes of white or brown fat, occurring in a specific population in a given time period" [MPATH:417]
Show

Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Tg(Myh6-Rxra)41Pcn/0
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Tet1tuft/Tet1tuft
Genetic Background: involves: 3H1/Lznf * BALB/c

Allelic Composition: Tet1tuft/Tet1tuft
Genetic Background: involves: 3H1/Lznf * M. m. castaneus

 MP:0010948 abnormal double-strand DNA break repair "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]
Show

Allelic Composition: Tet1Gt(RRG140)Byg/Tet1Gt(RRG140)Byg
Genetic Background: B6.129P2-Tet1Gt(RRG140)Byg

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Tet1Gt(RRG140)Byg/Tet1Gt(RRG140)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Tet1Gt(RRG140)Byg/Tet1Gt(RRG140)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Aipl1tvrm127/Aipl1tvrm127
Genetic Background: C57BL/6J-Aipl1tvrm127/Pjn

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Tet1Gt(RRG140)Byg/Tet1Gt(RRG140)Byg
Genetic Background: B6.129P2-Tet1Gt(RRG140)Byg

 MP:0011205 excessive folding of visceral yolk sac "the appearance of wrinkles or folds on the surface of the visceral yolk sac" [MGI:csmith, PMID:17881493]
Show

Allelic Composition: Tet1Gt(RRG140)Byg/Tet1Gt(RRG140)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011257 abnormal head fold morphology "any structural anomaly of the crescent-shaped, ventrally located fold of the embryonic disc at the future cephalic end of the developing embryo; it constitutes the first body fold, and initiates brain, foregut and heart development" [ISBN:0-683-40008-8, PMID:10791309]
Show

Allelic Composition: Tet1Gt(RRG140)Byg/Tet1Gt(RRG140)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0012260 encephalomeningocele "hernial protrusion of the brain and its meninges through an opening or defect in the skull, most often occuring in the occipital region" [ISBN:0-683-40008-8]
Show

Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Tg(Myh6-Rxra)41Pcn/0
Genetic Background: involves: 129S2/SvPas

 MP:0012307 impaired spatial learning "impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
Show

Allelic Composition: Tet1tm1Gxu/Tet1tm1.1Gxu,Tg(Nes-cre/ERT2)KEisc/0
Genetic Background: involves: 129 * C57BL/6J

 MP:0012540 abnormal lamina terminalis morphology "any structural anomaly of the anterior-most (rostral) portion of the wall of the neural tube, formed by closure of the anterior neuropore; the median strip of the anterior wall of the prosencephalon, which persists in a relatively unchanged state as the cerebral hemispheres grow out forward beyond the original anterior end of the prosencephalon; in the developed brain, the lamina terminalis remains as the thin rostral wall of the third ventricle, stretching from the bases of the major cerebral commissures (the anterior commissure, the commissure of the fornix, and the rostrum of the corpus callosum) to the dorsal surface of the optic chiasm" [MGI:anna]
Show

Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Tg(Myh6-Rxra)41Pcn/0
Genetic Background: involves: 129S2/SvPas

 MP:0030117 bifid nose "visually assessable vertical indentation, cleft, or depression of the nasal bridge, ridge and tip" [HP:0011803, PMID:19152422]
Show

Allelic Composition: Rxratm1Ipc/Rxratm1Ipc,Tg(Myh6-Rxra)41Pcn/0
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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