ENSG00000138336


Homo sapiens

Features
Gene ID: ENSG00000138336
  
Biological name :TET1
  
Synonyms : Q8NFU7 / TET1 / tet methylcytosine dioxygenase 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q21.3
Gene start: 68560656
Gene end: 68694482
  
Corresponding Affymetrix probe sets: 228906_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000362748
NCBI entrez gene - 80312     See in Manteia.
OMIM - 607790
RefSeq - XM_017016689
RefSeq - NM_030625
RefSeq - XM_017016687
RefSeq - XM_017016688
RefSeq - XM_011540204
RefSeq - XM_011540205
RefSeq - XM_011540207
RefSeq - XM_017016686
RefSeq Peptide - NP_085128
swissprot - Q8NFU7
Ensembl - ENSG00000138336
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tet1ENSDARG00000075230Danio rerio
 TET1ENSGALG00000031604Gallus gallus
 Tet1ENSMUSG00000047146Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TET2 / Q6N021 / tet methylcytosine dioxygenase 2ENSG0000016876921
TET3 / O43151 / tet methylcytosine dioxygenase 3ENSG0000018760521
CXXC4 / CXXC finger protein 4ENSG000001687724
CXXC5 / Q7LFL8 / CXXC finger protein 5ENSG000001716043


Protein motifs (from Interpro)
Interpro ID Name
 IPR002857  Zinc finger, CXXC-type
 IPR024779  2OGFeDO, oxygenase domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001826 inner cell mass cell differentiation ISS
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006493 protein O-linked glycosylation ISS
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0019827 stem cell population maintenance ISS
 biological_processGO:0031062 positive regulation of histone methylation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0080111 DNA demethylation IMP
 biological_processGO:0090310 negative regulation of methylation-dependent chromatin silencing IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0005506 iron ion binding IDA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA
 molecular_functionGO:0070579 methylcytosine dioxygenase activity IMP


Pathways (from Reactome)
Pathway description
TET1,2,3 and TDG demethylate DNA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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