ENSMUSG00000040945


Mus musculus

Features
Gene ID: ENSMUSG00000040945
  
Biological name :Rcc2
  
Synonyms : Protein RCC2 / Q8BK67 / Rcc2
  
Possible biological names infered from orthology : Q9P258 / regulator of chromosome condensation 2
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D3
Gene start: 140700541
Gene end: 140723220
  
Corresponding Affymetrix probe sets: 10509820 (MoGene1.0st)   1426897_at (Mouse Genome 430 2.0 Array)   1452226_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117448
Ensembl peptide - ENSMUSP00000038144
Ensembl peptide - ENSMUSP00000071163
NCBI entrez gene - 108911     See in Manteia.
MGI - MGI:1919784
RefSeq - NM_173867
RefSeq - XM_006538471
RefSeq Peptide - NP_776292
swissprot - A2AWQ2
swissprot - Q8BK67
Ensembl - ENSMUSG00000040945
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rcc2ENSDARG00000011510Danio rerio
 RCC2ENSGALG00000031684Gallus gallus
 RCC2ENSG00000179051Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rpgr / retinitis pigmentosa GTPase regulator / Q92834*ENSMUSG0000003117423
Rcbtb1 / regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 / Q8NDN9* / RCC1 and BTB domain containing protein 1*ENSMUSG0000003546919
Q99LJ7 / Rcbtb2 / regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 / O95199* / RCC1 and BTB domain containing protein 2*ENSMUSG0000002210619
Rcc1 / Q8VE37 / regulator of chromosome condensation 1 / P18754*ENSMUSG0000002889618
Rcc1l / Q9CYF5 / reculator of chromosome condensation 1 like / Q96I51* / RCC1 like*ENSMUSG0000006197918
Q80YD6 / Sergef / Secretion-regulating guanine nucleotide exchange factor / Q9UGK8*ENSMUSG0000003083915


Protein motifs (from Interpro)
Interpro ID Name
 IPR000408  Regulator of chromosome condensation, RCC1
 IPR009091  Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007229 integrin-mediated signaling pathway ISO
 biological_processGO:0010762 regulation of fibroblast migration IMP
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle ISO
 biological_processGO:0030334 regulation of cell migration IMP
 biological_processGO:0034260 negative regulation of GTPase activity ISO
 biological_processGO:0045184 establishment of protein localization IGI
 biological_processGO:0048041 focal adhesion assembly ISO
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051895 negative regulation of focal adhesion assembly IMP
 biological_processGO:0051987 positive regulation of attachment of spindle microtubules to kinetochore ISO
 biological_processGO:0072356 chromosome passenger complex localization to kinetochore ISO
 biological_processGO:0090630 activation of GTPase activity IGI
 biological_processGO:1900025 negative regulation of substrate adhesion-dependent cell spreading IMP
 biological_processGO:1900027 regulation of ruffle assembly IMP
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0031901 early endosome membrane IDA
 cellular_componentGO:0034506 chromosome, centromeric core domain ISO
 cellular_componentGO:1990023 mitotic spindle midzone ISO
 molecular_functionGO:0008017 microtubule binding ISO
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0019904 protein domain specific binding ISO
 molecular_functionGO:0031267 small GTPase binding ISO
 molecular_functionGO:0048365 Rac GTPase binding IPI


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0002591 decreased mean corpuscular volume "less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0008259 abnormal optic disc morphology "any structural anomaly of the area in the retina where all of the axons of the ganglion cells exit the retina to form the optic nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0013278 decreased fasted circulating glucose level "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Psphtm1.1(KOMP)Vlcg/Psphtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Psphtm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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