ENSG00000179051


Homo sapiens

Features
Gene ID: ENSG00000179051
  
Biological name :RCC2
  
Synonyms : Q9P258 / RCC2 / regulator of chromosome condensation 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p36.13
Gene start: 17406760
Gene end: 17439724
  
Corresponding Affymetrix probe sets: 224578_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000364585
Ensembl peptide - ENSP00000364582
NCBI entrez gene - 55920     See in Manteia.
OMIM - 609587
RefSeq - NM_001136204
RefSeq - NM_018715
RefSeq Peptide - NP_001129676
RefSeq Peptide - NP_061185
swissprot - Q9P258
swissprot - A0A024RAC5
Ensembl - ENSG00000179051
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rcc2ENSDARG00000011510Danio rerio
 RCC2ENSGALG00000031684Gallus gallus
 Rcc2ENSMUSG00000040945Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RPGR / Q92834 / retinitis pigmentosa GTPase regulatorENSG0000015631323
O95199 / RCBTB2 / RCC1 and BTB domain containing protein 2ENSG0000013616120
RCC1L / Q96I51 / RCC1 likeENSG0000027452319
Q8NDN9 / RCBTB1 / RCC1 and BTB domain containing protein 1ENSG0000013614419
RCC1 / P18754 / regulator of chromosome condensation 1ENSG0000018019817
Q9UGK8 / SERGEF / secretion regulating guanine nucleotide exchange factorENSG0000012915817


Protein motifs (from Interpro)
Interpro ID Name
 IPR000408  Regulator of chromosome condensation, RCC1
 IPR009091  Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0007229 integrin-mediated signaling pathway IDA
 biological_processGO:0010762 regulation of fibroblast migration IEA
 biological_processGO:0010971 positive regulation of G2/M transition of mitotic cell cycle IMP
 biological_processGO:0030334 regulation of cell migration ISS
 biological_processGO:0034260 negative regulation of GTPase activity ISS
 biological_processGO:0045184 establishment of protein localization IEA
 biological_processGO:0048041 focal adhesion assembly IDA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051895 negative regulation of focal adhesion assembly ISS
 biological_processGO:0051987 positive regulation of attachment of spindle microtubules to kinetochore IMP
 biological_processGO:0072356 chromosome passenger complex localization to kinetochore IMP
 biological_processGO:0090630 activation of GTPase activity IEA
 biological_processGO:1900025 negative regulation of substrate adhesion-dependent cell spreading ISS
 biological_processGO:1900027 regulation of ruffle assembly IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0030496 midbody IDA
 cellular_componentGO:0031901 early endosome membrane IEA
 cellular_componentGO:0034506 chromosome, centromeric core domain IDA
 cellular_componentGO:1990023 mitotic spindle midzone IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IMP
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0031267 small GTPase binding IPI
 molecular_functionGO:0048365 Rac GTPase binding IPI


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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