ENSMUSG00000041133


Mus musculus

Features
Gene ID: ENSMUSG00000041133
  
Biological name :Smc1a
  
Synonyms : Q9CU62 / Smc1a / structural maintenance of chromosomes 1A
  
Possible biological names infered from orthology : Q14683
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: F3
Gene start: 152016428
Gene end: 152062694
  
Corresponding Affymetrix probe sets: 10602599 (MoGene1.0st)   1417830_at (Mouse Genome 430 2.0 Array)   1417831_at (Mouse Genome 430 2.0 Array)   1417832_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044645
Ensembl peptide - ENSMUSP00000138113
NCBI entrez gene - 24061     See in Manteia.
MGI - MGI:1344345
RefSeq - XM_006528840
RefSeq - NM_019710
RefSeq Peptide - NP_062684
swissprot - Q9CU62
swissprot - S4R179
Ensembl - ENSMUSG00000041133
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smc1aENSDARG00000055754Danio rerio
 smc1alENSDARG00000058203Danio rerio
 SMC1AENSG00000072501Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Smc1b / Q920F6 / structural maintenance of chromosomes 1B / Q8NDV3*ENSMUSG0000002243252


Protein motifs (from Interpro)
Interpro ID Name
 IPR003395  RecF/RecN/SMC, N-terminal
 IPR010935  SMCs flexible hinge
 IPR024704  Structural maintenance of chromosomes protein
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029683  Structural maintenance of chromosomes protein 1A, metazoan
 IPR036277  SMCs flexible hinge superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007062 sister chromatid cohesion IEA
 biological_processGO:0007064 mitotic sister chromatid cohesion IEA
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0032876 negative regulation of DNA endoreduplication IEA
 biological_processGO:0051276 chromosome organization IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051321 meiotic cell cycle IPI
 biological_processGO:0072423 response to DNA damage checkpoint signaling IEA
 biological_processGO:1901673 regulation of mitotic spindle assembly IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000776 kinetochore IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0008278 cohesin complex IDA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0030893 meiotic cohesin complex IEA
 cellular_componentGO:0097431 mitotic spindle pole IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003682 chromatin binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0036033 mediator complex binding IDA
 molecular_functionGO:0044877 protein-containing complex binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Separation of Sister Chromatids
Establishment of Sister Chromatid Cohesion
Cohesin Loading onto Chromatin
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA damage response and repair proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Casp8tm1Syon/Casp8tm1Syon,Tg(Myh7-BVp35-EGFP)#Ksa/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Smc1atm1Mbk/Smc1atm1Mbk
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Smc1atm1Mbk/Smc1atm1Mbk
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Chek2tm1Mak/Chek2+,Rad50tm2Jpt/Rad50tm2Jpt
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Smc1atm1Mbk/Smc1atm1Mbk
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0004028 chromosome breakage "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Casp8tm1Syon/Casp8tm1Syon,Tg(Myh7-BVp35-EGFP)#Ksa/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Casp8tm1Syon/Casp8tm1Syon,Tg(Myh7-BVp35-EGFP)#Ksa/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0004227 increased cellular sensitivity to ionizing radiation "increased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp8tm1Syon/Casp8tm1Syon,Tg(Myh7-BVp35-EGFP)#Ksa/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Smc1atm1Mbk/Smc1atm1Mbk
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0005432 abnormal pro-B cell "anomalous structure, development, or number of cells in the developing B cell lineage that have displayed B cell surface markers, but have not yet completed heavy chain gene rearrangement" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rad50tm2Jpt/Rad50tm2Jpt,Smc1atm1Mbk/Smc1atm1Mbk
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

 MP:0008404 increased cellular sensitivity to methylmethanesulfonate "greater incidence of cell death following exposure to methylmethanesulfonate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp8tm1Syon/Casp8tm1Syon,Tg(Myh7-BVp35-EGFP)#Ksa/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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