ENSMUSG00000022432


Mus musculus

Features
Gene ID: ENSMUSG00000022432
  
Biological name :Smc1b
  
Synonyms : Q920F6 / Smc1b / structural maintenance of chromosomes 1B
  
Possible biological names infered from orthology : Q8NDV3
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E2
Gene start: 85064689
Gene end: 85131964
  
Corresponding Affymetrix probe sets: 10431182 (MoGene1.0st)   1449253_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000154461
Ensembl peptide - ENSMUSP00000023068
NCBI entrez gene - 140557     See in Manteia.
MGI - MGI:2154049
RefSeq - NM_080470
RefSeq Peptide - NP_536718
swissprot - A1L2Z0
swissprot - Q920F6
Ensembl - ENSMUSG00000022432
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smc1bENSDARG00000014402Danio rerio
 SMC1BENSGALG00000014228Gallus gallus
 SMC1BENSG00000077935Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Smc1a / Q9CU62 / structural maintenance of chromosomes 1A / Q14683*ENSMUSG0000004113351


Protein motifs (from Interpro)
Interpro ID Name
 IPR003395  RecF/RecN/SMC, N-terminal
 IPR010935  SMCs flexible hinge
 IPR024704  Structural maintenance of chromosomes protein
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036277  SMCs flexible hinge superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007062 sister chromatid cohesion IDA
 biological_processGO:0051276 chromosome organization IEA
 biological_processGO:0051321 meiotic cell cycle IPI
 cellular_componentGO:0000775 chromosome, centromeric region IDA
 cellular_componentGO:0000794 condensed nuclear chromosome IDA
 cellular_componentGO:0000795 synaptonemal complex IDA
 cellular_componentGO:0000800 lateral element IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0030893 meiotic cohesin complex ISO
 cellular_componentGO:0034991 nuclear meiotic cohesin complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Grntm1Blrl/Grntm1Blrl
Genetic Background: involves: C57BL/6J

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Gnaztm1Iah/Gnaz+
Genetic Background: C57BL/6JAnu-Gnaztm1Iah/Anu

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Tyrc-10J/Tyrc-10J
Genetic Background: CBA/J

Allelic Composition: Smc1btm1Jess/Smc1btm2.2Jess
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Tyrc-10J/Tyrc-10J
Genetic Background: CBA/J

Allelic Composition: Smc1btm1Jess/Smc1btm2.2Jess
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grntm1Blrl/Grntm1Blrl
Genetic Background: involves: C57BL/6J

 MP:0002682 reduced number of mature ovarian follicles "fewer than normal numbers of spehroidal cell aggregations in the ovary containing the ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tyrc-10J/Tyrc-10J
Genetic Background: CBA/J

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnaztm1Iah/Gnaz+
Genetic Background: C57BL/6JAnu-Gnaztm1Iah/Anu

Allelic Composition: Smc1bm1Ham/Smc1bm1Ham
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl * ICR

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gnaztm1Iah/Gnaz+
Genetic Background: C57BL/6JAnu-Gnaztm1Iah/Anu

Allelic Composition: Smc1bm1Ham/Smc1bm1Ham
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl * ICR

Allelic Composition: Smc1btm1Jess/Smc1btm2.2Jess
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gnaztm1Iah/Gnaz+
Genetic Background: C57BL/6JAnu-Gnaztm1Iah/Anu

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gnaztm1Iah/Gnaz+
Genetic Background: C57BL/6JAnu-Gnaztm1Iah/Anu

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Gnaztm1Iah/Gnaz+
Genetic Background: C57BL/6JAnu-Gnaztm1Iah/Anu

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smc1bm1Ham/Smc1bm1Ham
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl * ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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