ENSMUSG00000041168


Mus musculus

Features
Gene ID: ENSMUSG00000041168
  
Biological name :Lonp1
  
Synonyms : Lonp1 / Lon protease homolog, mitochondrial / Q8CGK3
  
Possible biological names infered from orthology : lon peptidase 1, mitochondrial / P36776
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: D
Gene start: 56614301
Gene end: 56626903
  
Corresponding Affymetrix probe sets: 10452118 (MoGene1.0st)   1428365_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041814
NCBI entrez gene - 74142     See in Manteia.
MGI - MGI:1921392
RefSeq - NM_028782
RefSeq Peptide - NP_083058
swissprot - Q8CGK3
Ensembl - ENSMUSG00000041168
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lonp1ENSDARG00000102765Danio rerio
 LONP1ENSGALG00000040492Gallus gallus
 LONP1ENSG00000196365Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lonp2 / Q9DBN5 / Lon protease homolog 2, peroxisomal / Q86WA8* / lon peptidase 2, peroxisomal*ENSMUSG0000004786631


Protein motifs (from Interpro)
Interpro ID Name
 IPR003111  Lon, substrate-binding domain
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR004815  Lon protease, bacterial/eukaryotic-type
 IPR008268  Peptidase S16, active site
 IPR008269  Peptidase S16, Lon proteolytic domain
 IPR014721  Ribosomal protein S5 domain 2-type fold, subgroup
 IPR015947  PUA-like superfamily
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR027065  Lon protease
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027503  Lon protease homologue, chloroplastic/mitochondrial


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006508 proteolysis IDA
 biological_processGO:0006515 protein quality control for misfolded or incompletely synthesized proteins IBA
 biological_processGO:0007005 mitochondrion organization IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0010044 response to aluminum ion IEA
 biological_processGO:0030163 protein catabolic process IEA
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IEA
 biological_processGO:0070407 oxidation-dependent protein catabolic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005759 mitochondrial matrix IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0042645 mitochondrial nucleoid IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001018 mitochondrial promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IDA
 molecular_functionGO:0003727 single-stranded RNA binding IEA
 molecular_functionGO:0004176 ATP-dependent peptidase activity ISO
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity IDA
 molecular_functionGO:0043531 ADP binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0051880 G-quadruplex DNA binding IEA
 molecular_functionGO:0070182 DNA polymerase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001488 increased startle reflex "reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Cacna1atm1.1Ehess/Cacna1atm1.1Ehess
Genetic Background: C57BL/6-Cacna1atm1.1Ehess

 MP:0002718 abnormal inner cell mass "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cacna1atm1.1Ehess/Cacna1atm1.1Ehess
Genetic Background: C57BL/6-Cacna1atm1.1Ehess

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1atm1.1Ehess/Cacna1atm1.1Ehess
Genetic Background: C57BL/6-Cacna1atm1.1Ehess

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1atm1.1Ehess/Cacna1atm1.1Ehess
Genetic Background: C57BL/6-Cacna1atm1.1Ehess

 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
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Allelic Composition: Cacna1atm1.1Ehess/Cacna1atm1.1Ehess
Genetic Background: C57BL/6-Cacna1atm1.1Ehess

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0011105 partial embryonic lethality between implantation and placentation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
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Allelic Composition: Cacna1atm1.1Ehess/Cacna1atm1.1Ehess
Genetic Background: C57BL/6-Cacna1atm1.1Ehess

 MP:0011639 decreased mitochondrial DNA content "less than expected amount of DNA contained within the mirochondria of a eukaryotic cell" [MGI:csmith]
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Allelic Composition: Cacna1atm1.1Ehess/Cacna1atm1.1Ehess
Genetic Background: C57BL/6-Cacna1atm1.1Ehess

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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