ENSMUSG00000041236


Mus musculus

Features
Gene ID: ENSMUSG00000041236
  
Biological name :Vps41
  
Synonyms : Q5KU39 / Vps41 / VPS41 HOPS complex subunit
  
Possible biological names infered from orthology : P49754
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A2
Gene start: 18717286
Gene end: 18866811
  
Corresponding Affymetrix probe sets: 10403765 (MoGene1.0st)   1433665_at (Mouse Genome 430 2.0 Array)   1433666_s_at (Mouse Genome 430 2.0 Array)   1437901_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000072729
NCBI entrez gene - 218035     See in Manteia.
MGI - MGI:1929215
RefSeq - NM_172120
RefSeq - XM_006516641
RefSeq Peptide - NP_742118
swissprot - Q5KU39
Ensembl - ENSMUSG00000041236
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vps41ENSDARG00000063573Danio rerio
 VPS41ENSGALG00000031635Gallus gallus
 VPS41ENSG00000006715Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000547  Clathrin, heavy chain/VPS, 7-fold repeat
 IPR001841  Zinc finger, RING-type
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016902  Vacuolar protein sorting-associated protein 41
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006623 protein targeting to vacuole IBA
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0008333 endosome to lysosome transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0034058 endosomal vesicle fusion IEA
 biological_processGO:0035542 regulation of SNARE complex assembly IBA
 biological_processGO:0042144 vacuole fusion, non-autophagic IBA
 biological_processGO:0045055 regulated exocytosis IEA
 biological_processGO:0046907 intracellular transport IEA
 biological_processGO:0048193 Golgi vesicle transport ISO
 biological_processGO:1902774 late endosome to lysosome transport IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005798 Golgi-associated vesicle IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0030123 AP-3 adaptor complex IEA
 cellular_componentGO:0030136 clathrin-coated vesicle ISO
 cellular_componentGO:0030897 HOPS complex IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0033263 CORVET complex IBA
 cellular_componentGO:0071439 clathrin complex IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IDA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043621 protein self-association IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051020 GTPase binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001674 abnormal triploblastic development "abnormal development of the three primary germ layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(MSV-SKI)33Hugh/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(MSV-SKI)33Hugh/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

 MP:0001685 abnormal endoderm development "failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(MSV-SKI)33Hugh/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(MSV-SKI)33Hugh/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(MSV-SKI)33Hugh/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

 MP:0003085 abnormal egg cylinder morphology "anomaly in the transient cup-like structure of the epiblast that consists of a single layer of embryonic cells" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(MSV-SKI)33Hugh/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

 MP:0003895 increased ectoderm apoptosis "increase in the number of ectoderm cells undergoing programmed cell death during development" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(MSV-SKI)33Hugh/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

 MP:0008546 abnormal vesicle-mediated transport "anomaly in the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell" [GO:0016192]
Show

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(MSV-SKI)33Hugh/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

 MP:0010117 abnormal lateral plate mesoderm "anomaly of the portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(MSV-SKI)33Hugh/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Acta1tm1Hrd/Acta1+,Tg(MSV-SKI)33Hugh/?
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6JArc)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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