ENSMUSG00000041272


Mus musculus

Features
Gene ID: ENSMUSG00000041272
  
Biological name :Tox
  
Synonyms : Q66JW3 / Thymocyte selection-associated high mobility group box protein TOX / Tox
  
Possible biological names infered from orthology : O94900 / thymocyte selection associated high mobility group box
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: A1
Gene start: 6686353
Gene end: 6991557
  
Corresponding Affymetrix probe sets: 10511416 (MoGene1.0st)   1425483_at (Mouse Genome 430 2.0 Array)   1425484_at (Mouse Genome 430 2.0 Array)   1442039_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037966
NCBI entrez gene - 252838     See in Manteia.
MGI - MGI:2181659
RefSeq - XM_017320230
RefSeq - NM_145711
RefSeq - XM_006537944
RefSeq - XM_006537945
RefSeq Peptide - NP_663757
swissprot - Q66JW3
Ensembl - ENSMUSG00000041272
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 toxENSDARG00000032317Danio rerio
 TOXENSGALG00000039102Gallus gallus
 TOXENSG00000198846Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tox3 / Q80W03 / TOX high mobility group box family member 3 / O15405*ENSMUSG0000004366848
Tox2 / TOX high mobility group box family member 2 / Q96NM4*ENSMUSG0000007460743
Tox4 / Q8BU11 / TOX high mobility group box family member 4 / O94842*ENSMUSG0000001683135
Ssrp1 / Q08943 / FACT complex subunit SSRP1 / Q08945* / structure specific recognition protein 1*ENSMUSG0000002706718


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Csahl4/Csahl4
Genetic Background: C57BL/6J-Chr 10A/J/NaJ

 MP:0004919 abnormal positive T cell selection "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Csahl4/Csahl4
Genetic Background: C57BL/6J-Chr 10A/J/NaJ

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Csahl4/Csahl4
Genetic Background: C57BL/6J-Chr 10A/J/NaJ

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
Show

Allelic Composition: Csahl4/Csahl4
Genetic Background: C57BL/6J-Chr 10A/J/NaJ

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csahl4/Csahl4
Genetic Background: C57BL/6J-Chr 10A/J/NaJ

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
Show

Allelic Composition: Csahl4/Csahl4
Genetic Background: C57BL/6J-Chr 10A/J/NaJ

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csahl4/Csahl4
Genetic Background: C57BL/6J-Chr 10A/J/NaJ

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csahl4/Csahl4
Genetic Background: C57BL/6J-Chr 10A/J/NaJ

Allelic Composition: Tg(Lck-cre)1Cwi/0,Toxtm1Kay/Toxtm1Kay
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008077 abnormal CD8-positive T cell number "anomaly in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csahl4/Csahl4
Genetic Background: C57BL/6J-Chr 10A/J/NaJ

 MP:0008133 decreased Peyer s patch number "reduction in the number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0008135 small Peyer s patches "reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0008397 abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology "any structural anomaly of a CD4-positive, CD25-positive, alpha-beta T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
Show

Allelic Composition: Csahl4/Csahl4
Genetic Background: C57BL/6J-Chr 10A/J/NaJ

 MP:0008465 absent mesenteric lymph nodes "absence of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0009622 absent inguinal lymph nodes "absence of the lymph nodes normally located in the groin area" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0009630 absent axillary lymph nodes "absence of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

 MP:0009634 absent popliteal lymph nodes "absence of the lymph nodes which drain the legs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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