ENSMUSG00000043668


Mus musculus

Features
Gene ID: ENSMUSG00000043668
  
Biological name :Tox3
  
Synonyms : Q80W03 / Tox3 / TOX high mobility group box family member 3
  
Possible biological names infered from orthology : O15405
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: C4
Gene start: 90247040
Gene end: 90348343
  
Corresponding Affymetrix probe sets: 10580522 (MoGene1.0st)   1436600_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105250
Ensembl peptide - ENSMUSP00000134931
Ensembl peptide - ENSMUSP00000135697
NCBI entrez gene - 244579     See in Manteia.
MGI - MGI:3039593
RefSeq - XM_011248379
RefSeq - NM_172913
RefSeq - XM_006530987
RefSeq - XM_006530988
RefSeq - XM_006530989
RefSeq Peptide - NP_766501
swissprot - H3BL89
swissprot - H3BJC5
swissprot - Q80W03
Ensembl - ENSMUSG00000043668
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tox3ENSDARG00000073957Danio rerio
 TOX3ENSGALG00000034649Gallus gallus
 TOX3ENSG00000103460Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tox / Q66JW3 / Thymocyte selection-associated high mobility group box protein TOX / O94900* / thymocyte selection associated high mobility group box*ENSMUSG0000004127243
Tox4 / Q8BU11 / TOX high mobility group box family member 4 / O94842*ENSMUSG0000001683137
Tox2 / TOX high mobility group box family member 2 / Q96NM4*ENSMUSG0000007460734
Ssrp1 / Q08943 / FACT complex subunit SSRP1 / Q08945* / structure specific recognition protein 1*ENSMUSG0000002706716


Protein motifs (from Interpro)
Interpro ID Name
 IPR009071  High mobility group box domain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR036910  High mobility group box domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0034056 estrogen response element binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0051219 phosphoprotein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Syt1tm1a(EUCOMM)Wtsi/Syt1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Syt1tm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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