ENSMUSG00000041939


Mus musculus

Features
Gene ID: ENSMUSG00000041939
  
Biological name :Mvk
  
Synonyms : Mevalonate kinase / Mvk / Q9R008
  
Possible biological names infered from orthology : Q03426
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 114444269
Gene end: 114460591
  
Corresponding Affymetrix probe sets: 10524555 (MoGene1.0st)   1418052_at (Mouse Genome 430 2.0 Array)   1430619_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107858
Ensembl peptide - ENSMUSP00000143347
Ensembl peptide - ENSMUSP00000142758
Ensembl peptide - ENSMUSP00000142376
Ensembl peptide - ENSMUSP00000114611
Ensembl peptide - ENSMUSP00000036971
NCBI entrez gene - 17855     See in Manteia.
MGI - MGI:107624
RefSeq - XM_006530185
RefSeq - NM_001306205
RefSeq - NM_023556
RefSeq - XM_006530183
RefSeq Peptide - NP_001293134
RefSeq Peptide - NP_076045
swissprot - Q3UEB4
swissprot - A0A0G2JEG0
swissprot - A0A0G2JDI0
swissprot - Q9R008
swissprot - A0A0G2JFX8
swissprot - D3YV77
Ensembl - ENSMUSG00000041939
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mvkENSDARG00000004130Danio rerio
 MVKENSGALG00000013848Gallus gallus
 MVKENSG00000110921Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR006203  GHMP kinase, ATP-binding, conserved site
 IPR006204  GHMP kinase N-terminal domain
 IPR006205  Mevalonate kinase
 IPR013750  GHMP kinase, C-terminal domain
 IPR014721  Ribosomal protein S5 domain 2-type fold, subgroup
 IPR019539  Galactokinase galactose-binding domain
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR036554  GHMP kinase, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006694 steroid biosynthetic process IEA
 biological_processGO:0006695 cholesterol biosynthetic process ISO
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0008299 isoprenoid biosynthetic process ISO
 biological_processGO:0016126 sterol biosynthetic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway IBA
 biological_processGO:0050728 negative regulation of inflammatory response ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004496 mevalonate kinase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005534 galactose binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
Cholesterol biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000041939 Mvk / Q9R008 / Mevalonate kinase / Q03426*  / complex






 

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