ENSMUSG00000042105


Mus musculus

Features
Gene ID: ENSMUSG00000042105
  
Biological name :Inpp5f
  
Synonyms : inositol polyphosphate-5-phosphatase F / Inpp5f / Q8CDA1
  
Possible biological names infered from orthology : Q9Y2H2
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F3
Gene start: 128611328
Gene end: 128696425
  
Corresponding Affymetrix probe sets: 10558001 (MoGene1.0st)   1433542_at (Mouse Genome 430 2.0 Array)   1442100_at (Mouse Genome 430 2.0 Array)   1447757_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113700
Ensembl peptide - ENSMUSP00000146197
Ensembl peptide - ENSMUSP00000143952
Ensembl peptide - ENSMUSP00000045910
NCBI entrez gene - 101490     See in Manteia.
MGI - MGI:2141867
RefSeq - NM_178641
RefSeq - XM_006507154
RefSeq Peptide - NP_001333446
RefSeq Peptide - NP_848756
swissprot - A0A0J9YU13
swissprot - Q8CDA1
swissprot - B2RQ14
Ensembl - ENSMUSG00000042105
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A8E7C5ENSDARG00000061437Danio rerio
 INPP5FENSGALG00000009445Gallus gallus
 INPP5FENSG00000198825Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9EP69 / Sacm1l / Mus musculus SAC1 suppressor of actin mutations 1-like (yeast) (Sacm1l), transcript variant 1, mRNA. / Q9NTJ5* / SAC1 like phosphatidylinositide phosphatase*ENSMUSG0000002524017


Protein motifs (from Interpro)
Interpro ID Name
 IPR002013  SAC domain
 IPR022158  Inositol phosphatase
 IPR034753  hSac2 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001921 positive regulation of receptor recycling IMP
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0014898 cardiac muscle hypertrophy in response to stress IMP
 biological_processGO:0031161 phosphatidylinositol catabolic process IMP
 biological_processGO:0033137 negative regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0042532 negative regulation of tyrosine phosphorylation of STAT protein ISS
 biological_processGO:0046856 phosphatidylinositol dephosphorylation IMP
 biological_processGO:0048015 phosphatidylinositol-mediated signaling IMP
 biological_processGO:0048681 negative regulation of axon regeneration IMP
 biological_processGO:0051896 regulation of protein kinase B signaling ISO
 biological_processGO:0070072 vacuolar proton-transporting V-type ATPase complex assembly IEA
 biological_processGO:0072583 clathrin-dependent endocytosis ISS
 biological_processGO:2000145 regulation of cell motility ISO
 biological_processGO:2001135 regulation of endocytic recycling ISO
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome ISO
 cellular_componentGO:0005905 clathrin-coated pit ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0045334 clathrin-coated endocytic vesicle ISO
 cellular_componentGO:0055037 recycling endosome ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008934 inositol monophosphate 1-phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0034595 phosphatidylinositol phosphate 5-phosphatase activity IEA
 molecular_functionGO:0034596 phosphatidylinositol phosphate 4-phosphatase activity IMP
 molecular_functionGO:0042578 phosphoric ester hydrolase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0052832 inositol monophosphate 3-phosphatase activity IEA
 molecular_functionGO:0052833 inositol monophosphate 4-phosphatase activity IEA
 molecular_functionGO:0052834 inositol monophosphate phosphatase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the early endosome membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dag1tm2Kcam/Dag1tm2Kcam,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dag1tm2Kcam/Dag1tm2Kcam,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Dag1tm2Kcam/Dag1tm2Kcam,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dag1tm2Kcam/Dag1tm2Kcam,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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