ENSMUSG00000042320


Mus musculus

Features
Gene ID: ENSMUSG00000042320
  
Biological name :Prox2
  
Synonyms : Prospero homeobox protein 2 / Prox2 / Q8BII1
  
Possible biological names infered from orthology : prospero homeobox 2 / Q3B8N5
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: D1
Gene start: 85086385
Gene end: 85110759
  
Corresponding Affymetrix probe sets: 10401586 (MoGene1.0st)   1430243_at (Mouse Genome 430 2.0 Array)   1442210_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000105878
Ensembl peptide - ENSMUSP00000135881
NCBI entrez gene - 73422     See in Manteia.
MGI - MGI:1920672
RefSeq - XM_011244187
RefSeq - NM_175198
RefSeq - XM_006516279
RefSeq - XM_006516281
RefSeq - XM_006516278
RefSeq Peptide - NP_780407
swissprot - Q8BII1
Ensembl - ENSMUSG00000042320
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prox2ENSDARG00000041952Danio rerio
 ENSGALG00000023113Gallus gallus
 PROX2ENSG00000119608Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prox1 / P48437 / Prospero homeobox protein 1 / Q92786* / prospero homeobox 1*ENSMUSG0000001017536


Protein motifs (from Interpro)
Interpro ID Name
 IPR009057  Homeobox-like domain superfamily
 IPR023082  Homeo-prospero domain
 IPR037131  Homeo-prospero domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0001946 lymphangiogenesis IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0030182 neuron differentiation IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0055007 cardiac muscle cell differentiation IBA
 biological_processGO:0060836 lymphatic endothelial cell differentiation IBA
 biological_processGO:0070309 lens fiber cell morphogenesis IBA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plp1tm1.1Gow/Y
Genetic Background: Not Specified

Allelic Composition: Prox2tm1Aoh/Prox2+
Genetic Background: either: (involves: 129 * 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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