ENSMUSG00000010175


Mus musculus

Features
Gene ID: ENSMUSG00000010175
  
Biological name :Prox1
  
Synonyms : P48437 / Prospero homeobox protein 1 / Prox1
  
Possible biological names infered from orthology : prospero homeobox 1 / Q92786
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H6
Gene start: 190118035
Gene end: 190170714
  
Corresponding Affymetrix probe sets: 10361023 (MoGene1.0st)   1421336_at (Mouse Genome 430 2.0 Array)   1437894_at (Mouse Genome 430 2.0 Array)   1457432_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000010319
Ensembl peptide - ENSMUSP00000135066
Ensembl peptide - ENSMUSP00000135703
NCBI entrez gene - 19130     See in Manteia.
MGI - MGI:97772
RefSeq - XM_006497128
RefSeq - NM_008937
RefSeq - XM_006497126
RefSeq - XM_006497127
RefSeq - XM_006497124
RefSeq - XM_006497125
RefSeq Peptide - NP_032963
swissprot - P48437
Ensembl - ENSMUSG00000010175
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prox1aENSDARG00000055158Danio rerio
 PROX1ENSGALG00000009791Gallus gallus
 PROX1ENSG00000117707Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prox2 / Q8BII1 / Prospero homeobox protein 2 / Q3B8N5* / prospero homeobox 2*ENSMUSG0000004232029


Protein motifs (from Interpro)
Interpro ID Name
 IPR007738  Prospero homeobox protein 1
 IPR009057  Homeobox-like domain superfamily
 IPR023082  Homeo-prospero domain
 IPR037131  Homeo-prospero domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0001709 cell fate determination IMP
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation ISO
 biological_processGO:0001945 lymph vessel development IMP
 biological_processGO:0001946 lymphangiogenesis IBA
 biological_processGO:0002088 lens development in camera-type eye IEA
 biological_processGO:0002089 lens morphogenesis in camera-type eye IMP
 biological_processGO:0002194 hepatocyte cell migration IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007623 circadian rhythm IEP
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0008285 negative regulation of cell proliferation ISO
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0010595 positive regulation of endothelial cell migration ISO
 biological_processGO:0021542 dentate gyrus development IMP
 biological_processGO:0021707 cerebellar granule cell differentiation IMP
 biological_processGO:0030240 skeletal muscle thin filament assembly IMP
 biological_processGO:0030324 lung development IEA
 biological_processGO:0031016 pancreas development IEA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0042752 regulation of circadian rhythm ISS
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity ISO
 biological_processGO:0045071 negative regulation of viral genome replication ISO
 biological_processGO:0045446 endothelial cell differentiation IMP
 biological_processGO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity ISO
 biological_processGO:0045787 positive regulation of cell cycle IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046619 optic placode formation involved in camera-type eye formation IEP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048839 inner ear development IMP
 biological_processGO:0048845 venous blood vessel morphogenesis IMP
 biological_processGO:0055005 ventricular cardiac myofibril assembly IMP
 biological_processGO:0055009 atrial cardiac muscle tissue morphogenesis IMP
 biological_processGO:0055010 ventricular cardiac muscle tissue morphogenesis IMP
 biological_processGO:0060059 embryonic retina morphogenesis in camera-type eye IEP
 biological_processGO:0060214 endocardium formation IMP
 biological_processGO:0060298 positive regulation of sarcomere organization IMP
 biological_processGO:0060412 ventricular septum morphogenesis IMP
 biological_processGO:0060414 aorta smooth muscle tissue morphogenesis IMP
 biological_processGO:0060421 positive regulation of heart growth IMP
 biological_processGO:0060836 lymphatic endothelial cell differentiation ISO
 biological_processGO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment ISO
 biological_processGO:0061114 branching involved in pancreas morphogenesis IMP
 biological_processGO:0070309 lens fiber cell morphogenesis IMP
 biological_processGO:0070365 hepatocyte differentiation IEP
 biological_processGO:0070858 negative regulation of bile acid biosynthetic process ISO
 biological_processGO:0072574 hepatocyte proliferation IMP
 biological_processGO:0090425 acinar cell differentiation IMP
 biological_processGO:0097150 neuronal stem cell population maintenance IMP
 biological_processGO:1901978 positive regulation of cell cycle checkpoint IMP
 biological_processGO:2000179 positive regulation of neural precursor cell proliferation IMP
 biological_processGO:2000979 positive regulation of forebrain neuron differentiation IMP
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm ISO
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003700 DNA-binding transcription factor activity NAS
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
 molecular_functionGO:0003714 transcription corepressor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016922 nuclear receptor binding ISO
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISO
 molecular_functionGO:0050692 DBD domain binding ISO
 molecular_functionGO:0050693 LBD domain binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Nkx2-1tm1Shk/Nkx2-1tm1Shk
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Prox1tm2Gco/Prox1+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * NMRI * SJL

 MP:0000596 abnormal liver development "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nkx2-1tm1Shk/Nkx2-1tm1Shk
Genetic Background: involves: 129S4/SvJae

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Nkx2-1tm1Shk/Nkx2-1tm1Shk
Genetic Background: involves: 129S4/SvJae

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Pkd1tm3Jzh/Pkd1tm3Jzh,Tg(Col2a1-cre)10Amc/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Prox1tm1.1Fuma/Prox1tm1.1Fuma,Tg(Camk2a-cre/ERT2)2Gsc/0
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/N

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Nkx2-1tm1Shk/Nkx2-1tm1Shk
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Nkx2-1tm1Shk/Nkx2-1tm1Shk
Genetic Background: involves: 129S4/SvJae

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Nkx2-1tm1Shk/Nkx2-1tm1Shk
Genetic Background: involves: 129S4/SvJae

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Nkx2-1tm1Shk/Nkx2-1tm1Shk
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

Allelic Composition: Prox1tm2Gco/Prox1+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * NMRI * SJL

Allelic Composition: Prox1tm4.1Gco/Prox1tm4.1Gco
Genetic Background: involves: 129S1/Sv * C57BL/10 * CBA/Ca

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Prox1tm3(cre/ERT2)Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0001855 atrial thrombosis "formation or presence of a thrombus in the atria of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx2-1tm1Shk/Nkx2-1tm1Shk
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Prox1tm2Gco/Prox1+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * NMRI * SJL

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa,Prox1tm3(cre/ERT2)Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myocdtm1Msp/Myocdtm1Msp
Genetic Background: involves: 129/Sv

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gfra2tm1Jmi/Gfra2tm1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002450 abnormal lymph organ development "anomaly in the process of morphological maturation of the organs of the lymph system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nkx2-1tm1Shk/Nkx2-1tm1Shk
Genetic Background: involves: 129S4/SvJae

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0002712 increased circulating glucagon level "greater than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0003212 susceptibility to age related obesity "increased probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

Allelic Composition: Prox1tm2Gco/Prox1+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * NMRI * SJL

 MP:0003659 abnormal lymph circulation "abnormalities in the flow of the lymph from the tissues into the veins of the circulatory system" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:95885]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

Allelic Composition: Prox1tm2Gco/Prox1+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * NMRI * SJL

 MP:0003660 chylothorax "an accumulation of chyle (fluid consisting of lymph and emulsified fats that is formed in the small intestine during digestion of fatty foods and taken up by the lymph vessels) in the thoracic cavity" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:95585]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

Allelic Composition: Prox1tm2Gco/Prox1+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * NMRI * SJL

 MP:0004001 decreased hepatocyte proliferation "reduced growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Nkx2-1tm1Shk/Nkx2-1tm1Shk
Genetic Background: involves: 129S4/SvJae

 MP:0004247 small pancreas "decrease of the size of the pancreas compared to controls" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx2-1tm1Shk/Nkx2-1tm1Shk
Genetic Background: involves: 129S4/SvJae

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0005545 abnormal lens development "aberrant formation of the transparent structure of the eye responsible for focusing light rays" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nkx2-1tm1Shk/Nkx2-1tm1Shk
Genetic Background: involves: 129S4/SvJae

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0008107 absent horizontal cells "absence of the laterally interconnecting neurons in the outer plexiform layer of the retina that connect rods of one part of the retina with cones in another part of the retina" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nkx2-1tm1Shk/Nkx2-1tm1Shk
Genetic Background: involves: 129S4/SvJae

 MP:0008269 abnormal hippocampus CA4 region morphology 
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Allelic Composition: Pkd1tm3Jzh/Pkd1tm3Jzh,Tg(Col2a1-cre)10Amc/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Prox1tm1.1Fuma/Prox1tm1.1Fuma,Tg(Camk2a-cre/ERT2)2Gsc/0
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/N

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Apctm1Tyj/Apctm1Tyj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008908 increased total fat pad weight "greater than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0009159 increased pancreatic acinar cell number "increased number of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nkx2-1tm1Shk/Nkx2-1tm1Shk
Genetic Background: involves: 129S4/SvJae

 MP:0009165 abnormal endocrine pancreas morphology "any structural anomaly of the smaller portion of the pancreas that secretes a number of hormones into the blood stream that are produced by the cells in the islets of Langerhans" [MESH:A03.734]
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Allelic Composition: Nkx2-1tm1Shk/Nkx2-1tm1Shk
Genetic Background: involves: 129S4/SvJae

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0009938 abnormal hippocampus granule cell morphology "any structural anomaly of the small neurons of the hippocampal granule cell layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pkd1tm3Jzh/Pkd1tm3Jzh,Tg(Col2a1-cre)10Amc/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Prox1tm1.1Fuma/Prox1tm1.1Fuma,Tg(Camk2a-cre/ERT2)2Gsc/0
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/N

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0010194 absent lymphatic vessels "absence of the network of vessels which carries lymph around the body" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gfra2tm1Jmi/Gfra2tm1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010198 decreased lymphatic vessel endothelial cell number "reduced number of the cells that line the lymphatic vessels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apctm1Tyj/Apctm1Tyj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Prox1tm4.1Gco/Prox1tm4.1Gco
Genetic Background: involves: 129S1/Sv * C57BL/10 * CBA/Ca

 MP:0010416 interventricular septum membranous part aneurysm "a a saclike thinning, stretching and widening of the ventricular membranous septum resulting from weakening of the membraneous septum wall" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0010498 abnormal interventricular septum muscular part morphology "any structural anomaly of the muscular portion of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0010626 thick tricuspid valve cusps 
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Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

Allelic Composition: Prox1tm2Gco/Prox1+,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * NMRI * SJL

Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Nkx2-1tm1Shk/Nkx2-1tm1Shk
Genetic Background: involves: 129S4/SvJae

 MP:0011964 increased total retina thickness "increased width of the retina through the center plane" [MGI:csmith]
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Allelic Composition: Prox1tm1Gco/Prox1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0020409 abnormal cardiac thrombosis "any anomaly in the formation or presence of thrombi in the heart" [PMID:15870284]
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Allelic Composition: Prox1tm2Gco/Prox1tm2Gco,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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