ENSG00000117707


Homo sapiens

Features
Gene ID: ENSG00000117707
  
Biological name :PROX1
  
Synonyms : prospero homeobox 1 / PROX1 / Q92786
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q32.3
Gene start: 213983181
Gene end: 214041502
  
Corresponding Affymetrix probe sets: 207401_at (Human Genome U133 Plus 2.0 Array)   228656_at (Human Genome U133 Plus 2.0 Array)   229376_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000420283
Ensembl peptide - ENSP00000419517
Ensembl peptide - ENSP00000475357
Ensembl peptide - ENSP00000261454
Ensembl peptide - ENSP00000355925
Ensembl peptide - ENSP00000400694
NCBI entrez gene - 5629     See in Manteia.
OMIM - 601546
RefSeq - XM_017001833
RefSeq - NM_001270616
RefSeq - NM_002763
RefSeq - XM_005273195
RefSeq - XM_011509771
RefSeq - XM_011509772
RefSeq - XM_011509773
RefSeq - XM_017001832
RefSeq - XM_005273194
RefSeq Peptide - NP_001257545
RefSeq Peptide - NP_002754
swissprot - Q92786
swissprot - U3KPY6
swissprot - C9JU29
Ensembl - ENSG00000117707
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prox1aENSDARG00000055158Danio rerio
 PROX1ENSGALG00000009791Gallus gallus
 Prox1ENSMUSG00000010175Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PROX2 / Q3B8N5 / prospero homeobox 2ENSG0000011960828


Protein motifs (from Interpro)
Interpro ID Name
 IPR007738  Prospero homeobox protein 1
 IPR009057  Homeobox-like domain superfamily
 IPR023082  Homeo-prospero domain
 IPR037131  Homeo-prospero domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001709 cell fate determination IEA
 biological_processGO:0001822 kidney development IEP
 biological_processGO:0001889 liver development IEP
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IDA
 biological_processGO:0001945 lymph vessel development IEA
 biological_processGO:0001946 lymphangiogenesis IDA
 biological_processGO:0002088 lens development in camera-type eye IEP
 biological_processGO:0002089 lens morphogenesis in camera-type eye IEA
 biological_processGO:0002194 hepatocyte cell migration IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007420 brain development IEP
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0010468 regulation of gene expression IDA
 biological_processGO:0010595 positive regulation of endothelial cell migration IDA
 biological_processGO:0021516 dorsal spinal cord development ISS
 biological_processGO:0021542 dentate gyrus development ISS
 biological_processGO:0021707 cerebellar granule cell differentiation ISS
 biological_processGO:0021915 neural tube development ISS
 biological_processGO:0030182 neuron differentiation IBA
 biological_processGO:0030240 skeletal muscle thin filament assembly ISS
 biological_processGO:0030324 lung development IEP
 biological_processGO:0030910 olfactory placode formation ISS
 biological_processGO:0031016 pancreas development IEP
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0043049 otic placode formation ISS
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0045071 negative regulation of viral genome replication IDA
 biological_processGO:0045446 endothelial cell differentiation IEA
 biological_processGO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IDA
 biological_processGO:0045787 positive regulation of cell cycle ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0046619 optic placode formation involved in camera-type eye formation ISS
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0048839 inner ear development IEA
 biological_processGO:0048845 venous blood vessel morphogenesis ISS
 biological_processGO:0055005 ventricular cardiac myofibril assembly ISS
 biological_processGO:0055007 cardiac muscle cell differentiation IBA
 biological_processGO:0055009 atrial cardiac muscle tissue morphogenesis ISS
 biological_processGO:0055010 ventricular cardiac muscle tissue morphogenesis ISS
 biological_processGO:0060042 retina morphogenesis in camera-type eye ISS
 biological_processGO:0060059 embryonic retina morphogenesis in camera-type eye IEP
 biological_processGO:0060214 endocardium formation ISS
 biological_processGO:0060298 positive regulation of sarcomere organization ISS
 biological_processGO:0060412 ventricular septum morphogenesis ISS
 biological_processGO:0060414 aorta smooth muscle tissue morphogenesis ISS
 biological_processGO:0060421 positive regulation of heart growth ISS
 biological_processGO:0060836 lymphatic endothelial cell differentiation IDA
 biological_processGO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment IMP
 biological_processGO:0061114 branching involved in pancreas morphogenesis IEA
 biological_processGO:0070309 lens fiber cell morphogenesis IEP
 biological_processGO:0070365 hepatocyte differentiation IEP
 biological_processGO:0070858 negative regulation of bile acid biosynthetic process IMP
 biological_processGO:0072574 hepatocyte proliferation IEA
 biological_processGO:0090425 acinar cell differentiation IEA
 biological_processGO:0097150 neuronal stem cell population maintenance ISS
 biological_processGO:1901978 positive regulation of cell cycle checkpoint IEA
 biological_processGO:2000179 positive regulation of neural precursor cell proliferation ISS
 biological_processGO:2000979 positive regulation of forebrain neuron differentiation ISS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding ISS
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IMP
 molecular_functionGO:0003700 DNA-binding transcription factor activity IC
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding ISS
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016922 nuclear receptor binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0050692 DBD domain binding IPI
 molecular_functionGO:0050693 LBD domain binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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