ENSDARG00000055158


Danio rerio

Features
Gene ID: ENSDARG00000055158
  
Biological name :prox1a
  
Synonyms : prospero homeobox 1a / prox1a
  
Possible biological names infered from orthology : P48437 / prospero homeobox 1 / Prospero homeobox protein 1 / PROX1 / Q92786
  
Species: Danio rerio
  
Chr. number: 17
Strand: -1
Band:
Gene start: 32822588
Gene end: 32865788
  
Corresponding Affymetrix probe sets: Dr.8139.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000071943
Ensembl peptide - ENSDARP00000134086
NCBI entrez gene - 30679     See in Manteia.
RefSeq - NM_131405
RefSeq Peptide - NP_571480
swissprot - F1QAE1
swissprot - A0A0R4IFI2
ZFIN ID - ZDB-GENE-980526-397
Ensembl - ENSDARG00000055158
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PROX1ENSGALG00000009791Gallus gallus
 PROX1ENSG00000117707Homo sapiens
 Prox1ENSMUSG00000010175Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
prox2 / prospero homeobox 2 / Q3B8N5* / Q8BII1* / Prospero homeobox protein 2 *ENSDARG0000004195235
prox1b / prospero homeobox 1bENSDARG0000008881021


Protein motifs (from Interpro)
Interpro ID Name
 IPR007738  Prospero homeobox protein 1
 IPR009057  Homeobox-like domain superfamily
 IPR023082  Homeo-prospero domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0001946 lymphangiogenesis IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0021884 forebrain neuron development IMP
 biological_processGO:0030239 myofibril assembly IMP
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0048885 neuromast deposition IMP
 biological_processGO:0048886 neuromast hair cell differentiation IMP
 biological_processGO:0055007 cardiac muscle cell differentiation IBA
 biological_processGO:0060836 lymphatic endothelial cell differentiation IBA
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000032 hypothalamus hypothalamus neuron decreased amount , abnormal
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 ZFA:0000243 neuromast neuromast somatic stem cell immature , abnormal
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 ZFA:0000940 posterior lateral line neuromast posterior lateral line neuromast decreased amount , abnormal
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 ZFA:0001094 whole organism whole organism edematous , abnormal
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 ZFA:0001115 trunk trunk anterior region lacks all parts of type thoracic duct , abnormal
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 ZFA:0005110 thoracic duct thoracic duct decreased length , abnormal
thoracic duct absent , abnormal
thoracic duct aplastic , abnormal
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 ZFA:0009367 neuromast hair cell neuromast hair cell decreased amount , abnormal
neuromast hair cell kinocilium absent , abnormal
Show

 ZFA:0009395 vascular lymphangioblast vascular lymphangioblast decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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