ENSMUSG00000042607


Mus musculus

Features
Gene ID: ENSMUSG00000042607
  
Biological name :Asb4
  
Synonyms : Asb4 / Mus musculus ankyrin repeat and SOCS box-containing 4 (Asb4), transcript variant 2, mRNA. / Q9WV71
  
Possible biological names infered from orthology : ankyrin repeat and SOCS box containing 4 / Q9Y574
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: A1
Gene start: 5383386
Gene end: 5433022
  
Corresponding Affymetrix probe sets: 10536324 (MoGene1.0st)   1423422_at (Mouse Genome 430 2.0 Array)   1433919_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040331
Ensembl peptide - ENSMUSP00000139245
NCBI entrez gene - 65255     See in Manteia.
MGI - MGI:1929751
RefSeq - XM_017321708
RefSeq - NM_001355662
RefSeq - NM_023048
RefSeq Peptide - NP_075535
RefSeq Peptide - NP_001342591
swissprot - Q3V229
swissprot - Q9WV71
Ensembl - ENSMUSG00000042607
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 asb4ENSDARG00000034988Danio rerio
 ENSGALG00000009691Gallus gallus
 ASB4ENSG00000005981Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Asb18 / Q8VHA6 / Ankyrin repeat and SOCS box protein 18 / Q6ZVZ8* / ankyrin repeat and SOCS box containing 18*ENSMUSG0000006708131
Asb16 / Q8VHS5 / Ankyrin repeat and SOCS box protein 16 / Q96NS5* / ankyrin repeat and SOCS box containing 16*ENSMUSG0000003476831
Asb10 / Q91ZT7 / Ankyrin repeat and SOCS box protein 10 / Q8WXI3* / ankyrin repeat and SOCS box containing 10*ENSMUSG0000003820430


Protein motifs (from Interpro)
Interpro ID Name
 IPR001496  SOCS box domain
 IPR002110  Ankyrin repeat
 IPR020683  Ankyrin repeat-containing domain
 IPR036036  SOCS box-like domain superfamily
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0051865 protein autoubiquitination IDA
 biological_processGO:2001214 positive regulation of vasculogenesis IDA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0031462 Cul2-RING ubiquitin ligase complex IEA
 cellular_componentGO:0031466 Cul5-RING ubiquitin ligase complex IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IDA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA


Pathways (from Reactome)
Pathway description
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1dtm1Yhf/Hist1h1dtm1Yhf,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001713 reduced trophoblast cell number "fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:23171]
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Allelic Composition: Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1dtm1Yhf/Hist1h1dtm1Yhf,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1dtm1Yhf/Hist1h1dtm1Yhf,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1dtm1Yhf/Hist1h1dtm1Yhf,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1dtm1Yhf/Hist1h1dtm1Yhf,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1dtm1Yhf/Hist1h1dtm1Yhf,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1dtm1Yhf/Hist1h1dtm1Yhf,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1dtm1Yhf/Hist1h1dtm1Yhf,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0009661 abnormal pregnancy "any anomaly in the process of maintaining a developing embryo or fetus within the female body from conception to birth" [ISBN:0198542771 "Rugh, Roberts, The Mouse: Its Reproduction and Development", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1dtm1Yhf/Hist1h1dtm1Yhf,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0010695 abnormal blood pressure regulation "any anomaly in the process that modulates the force with which blood travels through the circulatory system, which is controlled by a balance of processes that increase pressure and decrease pressure" [GO:0008217]
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Allelic Composition: Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1dtm1Yhf/Hist1h1dtm1Yhf,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0011320 abnormal glomerular capillary morphology "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith]
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Allelic Composition: Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1dtm1Yhf/Hist1h1dtm1Yhf,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0011339 abnormal glomerular mesangium morphology "any structural anomaly of the inner layer of the glomerulus within the basement membrane surrounding the glomerular capillaries that contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1dtm1Yhf/Hist1h1dtm1Yhf,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0020153 abnormal urine albumin level "anomaly in the amount of albumin in the urine" [GOC:NV]
Show

Allelic Composition: Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1dtm1Yhf/Hist1h1dtm1Yhf,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129 * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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