ENSMUSG00000042751


Mus musculus

Features
Gene ID: ENSMUSG00000042751
  
Biological name :Nmnat2
  
Synonyms : Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 / Nmnat2 / Q8BNJ3
  
Possible biological names infered from orthology : nicotinamide nucleotide adenylyltransferase 2 / Q9BZQ4
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: G3
Gene start: 152954993
Gene end: 153119261
  
Corresponding Affymetrix probe sets: 10350697 (MoGene1.0st)   1436155_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140497
Ensembl peptide - ENSMUSP00000140585
Ensembl peptide - ENSMUSP00000041110
NCBI entrez gene - 226518     See in Manteia.
MGI - MGI:2444155
RefSeq - NM_175460
RefSeq - XM_006529455
RefSeq - XM_006529456
RefSeq Peptide - NP_780669
swissprot - Q5HZI3
swissprot - A0A087WR71
swissprot - A0A087WRE3
swissprot - Q8BNJ3
Ensembl - ENSMUSG00000042751
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nmnat2ENSDARG00000004580Danio rerio
 NMNAT2ENSGALG00000004642Gallus gallus
 NMNAT2ENSG00000157064Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nmnat1 / Q9EPA7 / Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 / Q9HAN9* / nicotinamide nucleotide adenylyltransferase 1*ENSMUSG0000002899233
Nmnat3 / Q99JR6 / Mus musculus nicotinamide nucleotide adenylyltransferase 3 (Nmnat3), transcript variant 2, mRNA. / Q96T66* / nicotinamide nucleotide adenylyltransferase 3*ENSMUSG0000003245632


Protein motifs (from Interpro)
Interpro ID Name
 IPR004821  Cytidyltransferase-like domain
 IPR014729  Rossmann-like alpha/beta/alpha sandwich fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009058 biosynthetic process IEA
 biological_processGO:0009435 NAD biosynthetic process IEA
 biological_processGO:0019363 pyridine nucleotide biosynthetic process IEA
 biological_processGO:0034628 "de novo" NAD biosynthetic process from aspartate IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005770 late endosome IDA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005802 trans-Golgi network IDA
 cellular_componentGO:0045202 synapse IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000309 nicotinamide-nucleotide adenylyltransferase activity IBA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004515 nicotinate-nucleotide adenylyltransferase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Nicotinate metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nmnat2Tn(sb-Tyr)2172.P9KK4BOve/Nmnat2Tn(sb-Tyr)2172.P9KK4BOve
Genetic Background: involves: FVB/N

 MP:0000537 abnormal urethra morphology "anomalous structure of the canal leading from the bladder, discharging the urine externally" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nmnat2Tn(sb-Tyr)2172.P9KK4BOve/Nmnat2Tn(sb-Tyr)2172.P9KK4BOve
Genetic Background: involves: FVB/N

 MP:0000539 distended urinary bladder "stretched musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Nmnat2Tn(sb-Tyr)2172.P9KK4BOve/Nmnat2Tn(sb-Tyr)2172.P9KK4BOve
Genetic Background: involves: FVB/N

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Nmnat2Tn(sb-Tyr)2172.P9KK4BOve/Nmnat2Tn(sb-Tyr)2172.P9KK4BOve
Genetic Background: involves: FVB/N

 MP:0000778 abnormal tract 
Show

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0000909 abnormal facial motor nucleus morphology "malformation or disorganization of the group of motor neurons residing in the pons that innervate the muscles of facial expression" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Nmnat2Tn(sb-Tyr)2172.P9KK4BOve/Nmnat2Tn(sb-Tyr)2172.P9KK4BOve
Genetic Background: involves: FVB/N

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Nmnat2Tn(sb-Tyr)2172.P9KK4BOve/Nmnat2Tn(sb-Tyr)2172.P9KK4BOve
Genetic Background: involves: FVB/N

 MP:0000958 peripheral nervous system degeneration "a retrogressive impairment of function or destruction of the ganglia and peripheral nerves that lie outside the brain and spinal cord" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nmnat2Tn(sb-Tyr)2172.P9KK4BOve/Nmnat2Tn(sb-Tyr)2172.P9KK4BOve
Genetic Background: involves: FVB/N

 MP:0000964 small dorsal root ganglia "reduced size of the dorsal root ganglia" [J:17123]
Show

Allelic Composition: Nmnat2Tn(sb-Tyr)2172.P9KK4BOve/Nmnat2Tn(sb-Tyr)2172.P9KK4BOve
Genetic Background: involves: FVB/N

 MP:0000966 reduced sensory neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Nmnat2Tn(sb-Tyr)2172.P9KK4BOve/Nmnat2Tn(sb-Tyr)2172.P9KK4BOve
Genetic Background: involves: FVB/N

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Nmnat2Tn(sb-Tyr)2172.P9KK4BOve/Nmnat2Tn(sb-Tyr)2172.P9KK4BOve
Genetic Background: involves: FVB/N

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001332 abnormal optic nerve innervation "misprojection or aberrant target finding of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001334 absent optic tract "absence of the set of cell bodies and nerve fibers conducting impulses from the retina to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
Show

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Nmnat2Tn(sb-Tyr)2172.P9KK4BOve/Nmnat2Tn(sb-Tyr)2172.P9KK4BOve
Genetic Background: involves: FVB/N

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Nmnat2Tn(sb-Tyr)2172.P9KK4BOve/Nmnat2Tn(sb-Tyr)2172.P9KK4BOve
Genetic Background: involves: FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nmnat2Gt(EUCE0262a08)Hmgu/Nmnat2Gt(EUCE0262a08)Hmgu,Wlds/+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6Ola

Allelic Composition: Nmnat2Gt(EUCE0262a08)Hmgu/Nmnat2Gt(RRF238)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Nmnat2Tn(sb-Tyr)2172.P9KK4BOve/Nmnat2Tn(sb-Tyr)2172.P9KK4BOve
Genetic Background: involves: FVB/N

 MP:0003491 abnormal voluntary movement "anomalies in coordinated movements executed with a purpose and can be improved by learning and/or experience" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0003590 ureteral reflux "retrograde movement of urine from the bladder to the kidney" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Nmnat2Tn(sb-Tyr)2172.P9KK4BOve/Nmnat2Tn(sb-Tyr)2172.P9KK4BOve
Genetic Background: involves: FVB/N

 MP:0003624 anuria "inability to form or excrete urine" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
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Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0004232 decreased muscle weight "less than average muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Nmnat2Tn(sb-Tyr)2172.P9KK4BOve/Nmnat2Tn(sb-Tyr)2172.P9KK4BOve
Genetic Background: involves: FVB/N

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nmnat2Tn(sb-Tyr)2172.P9KK4BOve/Nmnat2Tn(sb-Tyr)2172.P9KK4BOve
Genetic Background: involves: FVB/N

Allelic Composition: Nmnat2Gt(EUCE0262a08)1.1Hmgu/Nmnat2Gt(EUCE0262a08)1.1Hmgu
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

Allelic Composition: Nmnat2Gt(EUCE0262a08)1.1Hmgu/Nmnat2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
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Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0008492 dorsal root ganglion degeneration "retrogressive pathological change of a group of sensory nerve cell bodies located on the dorsal spinal roots within the vertebral column" [MESH:A08.340.390.340]
Show

Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nmnat2Tn(sb-Tyr)2172.P9KK4BOve/Nmnat2Tn(sb-Tyr)2172.P9KK4BOve
Genetic Background: involves: FVB/N

 MP:0010057 abnormal olfactory bulb outer nerve layer moprhology "any strucutral anomaly of the outerpost layer of the olfactory bulb; consists primarily of olfactory afferent axons and ensheathing glia" [PMID:12533617]
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Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Nmnat2Tn(sb-Tyr)2172.P9KK4BOve/Nmnat2Tn(sb-Tyr)2172.P9KK4BOve
Genetic Background: involves: FVB/N

Allelic Composition: Nmnat2Gt(EUCE0262a08)Hmgu/Nmnat2Gt(EUCE0262a08)Hmgu,Wlds/+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BL/6Ola

 MP:0012251 abnormal diaphragm development "malformation or incomplete differentiation of the thin musculomembranous barrier separating the abdominal and thoracic cavities and functioning in respiration" [MGI:anna]
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Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Nmnat2Tn(sb-Tyr)2172.P9KK4BOve/Nmnat2Tn(sb-Tyr)2172.P9KK4BOve
Genetic Background: involves: FVB/N

 MP:0012484 decreased corticospinal tract size "reduced size of the corticospinal fibers that arise from the pyramidal cells within the cerebral cortex layer V of the precentral motor area, the premotor area and the postcentral gyrus, then descend into and through the medulla to form the lateral corticospinal tract and the anterior corticospinal tract" [ISBN:0-683-40008-8]
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Allelic Composition: E2f7tm1Gle/E2f7tm1Gle,E2f8tm1Gle/E2f8tm1Gle,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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