ENSMUSG00000032456


Mus musculus

Features
Gene ID: ENSMUSG00000032456
  
Biological name :Nmnat3
  
Synonyms : Mus musculus nicotinamide nucleotide adenylyltransferase 3 (Nmnat3), transcript variant 2, mRNA. / Nmnat3 / Q99JR6
  
Possible biological names infered from orthology : nicotinamide nucleotide adenylyltransferase 3 / Q96T66
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: E3.3
Gene start: 98287435
Gene end: 98420438
  
Corresponding Affymetrix probe sets: 10588028 (MoGene1.0st)   1424899_at (Mouse Genome 430 2.0 Array)   1432342_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108557
Ensembl peptide - ENSMUSP00000108559
Ensembl peptide - ENSMUSP00000108560
Ensembl peptide - ENSMUSP00000141111
NCBI entrez gene - 74080     See in Manteia.
MGI - MGI:1921330
RefSeq - XM_017313630
RefSeq - NM_001357445
RefSeq - NM_144533
RefSeq - XM_006511502
RefSeq - XM_006511503
RefSeq - XM_006511504
RefSeq - XM_006511505
RefSeq - XM_006511506
RefSeq - XM_006511507
RefSeq - XM_011242826
RefSeq - XM_011242827
RefSeq Peptide - NP_653116
RefSeq Peptide - NP_001344374
RefSeq Peptide - NP_001344378
RefSeq Peptide - NP_001344380
RefSeq Peptide - NP_001344381
swissprot - Q99JR6
swissprot - Q3V3C7
swissprot - Q3V3F1
swissprot - A0A087WSM7
Ensembl - ENSMUSG00000032456
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NMNAT3ENSDARG00000077034Danio rerio
 NMNAT3ENSGALG00000026187Gallus gallus
 NMNAT3ENSG00000163864Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nmnat1 / Q9EPA7 / Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 / Q9HAN9* / nicotinamide nucleotide adenylyltransferase 1*ENSMUSG0000002899248
Nmnat2 / Q8BNJ3 / Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 / Q9BZQ4* / nicotinamide nucleotide adenylyltransferase 2*ENSMUSG0000004275140


Protein motifs (from Interpro)
Interpro ID Name
 IPR004821  Cytidyltransferase-like domain
 IPR005248  Nicotinate/nicotinamide nucleotide adenylyltransferase
 IPR014729  Rossmann-like alpha/beta/alpha sandwich fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009058 biosynthetic process IEA
 biological_processGO:0009435 NAD biosynthetic process IEA
 biological_processGO:0009611 response to wounding IDA
 biological_processGO:0019363 pyridine nucleotide biosynthetic process IEA
 biological_processGO:0034628 "de novo" NAD biosynthetic process from aspartate IBA
 cellular_componentGO:0005739 mitochondrion IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000309 nicotinamide-nucleotide adenylyltransferase activity IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004515 nicotinate-nucleotide adenylyltransferase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Nicotinate metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0000256 echinocytosis "a state in which the red blood cells have multiple small projections appearing over the cell circumference resembling a small burr or a sea urchin" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, J:82330, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001585 hemolytic anemia "an anemic condition resulting from an increased rate of erythrocyte destruction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0003656 abnormal erythrocyte physiology "functional anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0008476 increased spleen red pulp amount "increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0008809 increased spleen iron level "increase in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0010035 increased erythrocyte clearance "increased elimination of aging erythrocytes from the body by autoregulatory mechanisms, often expressed as half-life" [GO:0034102, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0010177 acanthocytosis "presence of erythrocytes characterized by multiple spiny (thorn-like) cytoplasmic projections" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032456 Nmnat3 / Q99JR6 / Mus musculus nicotinamide nucleotide adenylyltransferase 3 (Nmnat3), transcript variant 2, mRNA. / Q96T66* / nicotinamide nucleotide adenylyltransferase 3*  / complex






 

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