ENSMUSG00000042797


Mus musculus

Features
Gene ID: ENSMUSG00000042797
  
Biological name :Aqp11
  
Synonyms : Aqp11 / Aquaporin-11 / Q8BHH1
  
Possible biological names infered from orthology : Q8NBQ7
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E1
Gene start: 97724006
Gene end: 97738289
  
Corresponding Affymetrix probe sets: 10565627 (MoGene1.0st)   1429254_at (Mouse Genome 430 2.0 Array)   1436630_at (Mouse Genome 430 2.0 Array)   1447606_x_at (Mouse Genome 430 2.0 Array)   1455411_at (Mouse Genome 430 2.0 Array)   1455846_at (Mouse Genome 430 2.0 Array)   1457141_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146215
Ensembl peptide - ENSMUSP00000082054
NCBI entrez gene - 66333     See in Manteia.
MGI - MGI:1913583
RefSeq - NM_175105
RefSeq Peptide - NP_780314
swissprot - A0A0X1KG63
swissprot - Q8BHH1
Ensembl - ENSMUSG00000042797
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aqp11ENSDARG00000100555Danio rerio
 AQP11ENSGALG00000031734Gallus gallus
 AQP11ENSG00000178301Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aqp12 / Q8CHJ2 / Aquaporin-12 / A6NM10* / AQP12A* / AQP12B* / Q8IXF9* / aquaporin 12A* / aquaporin 12B*ENSMUSG0000004509127


Protein motifs (from Interpro)
Interpro ID Name
 IPR000425  Major intrinsic protein
 IPR016697  Aquaporin 11/12
 IPR023266  Aquaporin 11
 IPR023271  Aquaporin-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0006833 water transport IDA
 biological_processGO:0048388 endosomal lumen acidification IMP
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0072014 proximal tubule development IMP
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 molecular_functionGO:0015250 water channel activity IDA
 molecular_functionGO:0015267 channel activity IEA


Pathways (from Reactome)
Pathway description
Passive transport by Aquaporins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Apptm1b(KOMP)Wtsi/Apptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0000521 abnormal kidney cortex "anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smoc1Tn(sb-lacZ,GFP)IR3.1Jtak/Smoc1Tn(sb-lacZ,GFP)IR3.1Jtak
Genetic Background: involves: C3H * C57BL/6 * DBA/2 * ICR

Allelic Composition: Aqp11sjds/Aqp11tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * BALB/cRl * C57BL/6 * CD-1

Allelic Composition: Aqp11tm1Lex/Aqp11tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 * CD-1

 MP:0000522 cysts in kidney cortex "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ryr1tm1.1Msnr/Ryr1tm1.1Msnr
Genetic Background: 129S.129P2-Ryr1tm1.1Msnr

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Smoc1Tn(sb-lacZ,GFP)IR3.1Jtak/Smoc1Tn(sb-lacZ,GFP)IR3.1Jtak
Genetic Background: involves: C3H * C57BL/6 * DBA/2 * ICR

Allelic Composition: Aqp11tm1Lex/Aqp11tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 * CD-1

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
Show

Allelic Composition: Aqp11tm1.1Nlsn/Aqp11tm1.1Nlsn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Aqp11tm1Lex/Aqp11tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 * CD-1

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aqp11tm1.1Nlsn/Aqp11tm1.1Nlsn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aqp11tm1.1Nlsn/Aqp11tm1.1Nlsn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smoc1Tn(sb-lacZ,GFP)IR3.1Jtak/Smoc1Tn(sb-lacZ,GFP)IR3.1Jtak
Genetic Background: involves: C3H * C57BL/6 * DBA/2 * ICR

Allelic Composition: Aqp11sjds/Aqp11tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * BALB/cRl * C57BL/6 * CD-1

Allelic Composition: Aqp11tm1Lex/Aqp11tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 * CD-1

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
Show

Allelic Composition: Aqp11sjds/Aqp11sjds
Genetic Background: involves: BALB/cRl

Allelic Composition: Aqp11tm1Lex/Aqp11tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 * CD-1

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0003442 decreased circulating glycerol level "lower than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Aqp11tm1.1Nlsn/Aqp11tm1.1Nlsn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0003458 decreased circulating ketone body level "less than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Aqp11tm1.1Nlsn/Aqp11tm1.1Nlsn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Aqp11sjds/Aqp11sjds
Genetic Background: involves: BALB/cRl

Allelic Composition: Aqp11tm1Lex/Aqp11tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 * CD-1

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Aqp11sjds/Aqp11sjds
Genetic Background: involves: BALB/cRl

 MP:0004969 pale kidney "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Aqp11sjds/Aqp11sjds
Genetic Background: involves: BALB/cRl

Allelic Composition: Aqp11sjds/Aqp11tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * BALB/cRl * C57BL/6 * CD-1

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Aqp11tm1.1Nlsn/Aqp11tm1.1Nlsn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Aqp11sjds/Aqp11sjds
Genetic Background: involves: BALB/cRl

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Aqp11sjds/Aqp11sjds
Genetic Background: involves: BALB/cRl

Allelic Composition: Aqp11sjds/Aqp11tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * BALB/cRl * C57BL/6 * CD-1

Allelic Composition: Aqp11tm1Lex/Aqp11tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 * CD-1

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aqp11tm1.1Nlsn/Aqp11tm1.1Nlsn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0009378 abnormal endoplasmic reticulum morphology "any structural anomaly of irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells" [GO:0005783]
Show

Allelic Composition: Aqp11tm1.1Nlsn/Aqp11tm1.1Nlsn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aqp11sjds/Aqp11sjds
Genetic Background: involves: BALB/cRl

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Nell1l7R6-3R/Nell1l7R6-3R
Genetic Background: involves: BJR

Allelic Composition: Aqp11sjds/Aqp11sjds
Genetic Background: involves: BALB/cRl

Allelic Composition: Aqp11sjds/Aqp11tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * BALB/cRl * C57BL/6 * CD-1

 MP:0011352 proximal convoluted tubule brush border loss "attenuation or degeneration of the microvillus brush border normally present on the luminal surface of epithelial cells of the proximal convoluted tubule; may be associated with renal tubular injury and/or cystic changes" [MGI:anna]
Show

Allelic Composition: Aqp11sjds/Aqp11sjds
Genetic Background: involves: BALB/cRl

 MP:0011436 decreased urine magnesium level "lower than normal amount of magnesium in the urine" [MGI:anna]
Show

Allelic Composition: Apptm1b(KOMP)Wtsi/Apptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000042797 Aqp11 / Q8BHH1 / Aquaporin-11 / Q8NBQ7*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr