ENSMUSG00000045091


Mus musculus

Features
Gene ID: ENSMUSG00000045091
  
Biological name :Aqp12
  
Synonyms : Aqp12 / Aquaporin-12 / Q8CHJ2
  
Possible biological names infered from orthology : A6NM10 / AQP12A / AQP12B / aquaporin 12A / aquaporin 12B / Q8IXF9
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: D
Gene start: 93006334
Gene end: 93012269
  
Corresponding Affymetrix probe sets: 10348697 (MoGene1.0st)   1434464_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000060622
NCBI entrez gene - 208760     See in Manteia.
MGI - MGI:2664636
RefSeq - NM_177587
RefSeq - NM_001159658
RefSeq Peptide - NP_001153130
RefSeq Peptide - NP_808255
swissprot - Q8CHJ2
Ensembl - ENSMUSG00000045091
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aqp12ENSDARG00000043279Danio rerio
 AQP12AENSGALG00000006436Gallus gallus
 A6NM10ENSG00000185176Homo sapiens
 AQP12AENSG00000184945Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aqp11 / Q8BHH1 / Aquaporin-11 / Q8NBQ7*ENSMUSG0000004279725


Protein motifs (from Interpro)
Interpro ID Name
 IPR000425  Major intrinsic protein
 IPR016697  Aquaporin 11/12
 IPR023265  Aquaporin 12
 IPR023271  Aquaporin-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0015267 channel activity IEA


Pathways (from Reactome)
Pathway description
Passive transport by Aquaporins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003982 increased cholesterol level "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Trpm5tm1Dgen/Trpm5tm1Dgen
Genetic Background: B6.129P2-Trpm5tm1Dgen

 MP:0004761 susceptibility to induced pancreatitis "more likely than normal to develop an inflammatory response, or an increased inflammatory response in the pancreatic tissue after experimental manipulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Trpm5tm1Dgen/Trpm5tm1Dgen
Genetic Background: B6.129P2-Trpm5tm1Dgen

 MP:0009160 abnormal pancreatic acinar cell zymogen granule "any structural anomaly of a membrane-bounded, cytoplasmic secretory granule found in pancreatic acinar cells and contains inactive digestive enzyme precursors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trpm5tm1Dgen/Trpm5tm1Dgen
Genetic Background: B6.129P2-Trpm5tm1Dgen

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000045091 Aqp12 / Q8CHJ2 / Aquaporin-12 / A6NM10* / AQP12A* / AQP12B* / Q8IXF9* / aquaporin 12A* / aquaporin 12B*  / complex






 

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