ENSMUSG00000043648


Mus musculus

Features
Gene ID: ENSMUSG00000043648
  
Biological name :Pld6
  
Synonyms : Mitochondrial cardiolipin hydrolase / Pld6 / Q5SWZ9
  
Possible biological names infered from orthology : phospholipase D family member 6 / Q8N2A8
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B1.3
Gene start: 59783897
Gene end: 59787645
  
Corresponding Affymetrix probe sets: 10386423 (MoGene1.0st)   1438493_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115503
NCBI entrez gene - 194908     See in Manteia.
MGI - MGI:2687283
RefSeq - NM_183139
RefSeq - NM_001290283
RefSeq Peptide - NP_001277212
RefSeq Peptide - NP_898962
swissprot - Q5SWZ9
Ensembl - ENSMUSG00000043648
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pld6ENSDARG00000059951Danio rerio
 PLD6ENSG00000179598Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001736  Phospholipase D/Transphosphatidylase
 IPR025202  Phospholipase D-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0008053 mitochondrial fusion IEA
 biological_processGO:0010636 positive regulation of mitochondrial fusion IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030719 P granule organization IMP
 biological_processGO:0034587 piRNA metabolic process IMP
 biological_processGO:0043046 DNA methylation involved in gamete generation IMP
 biological_processGO:0051321 meiotic cell cycle IMP
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane TAS
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004521 endoribonuclease activity EXP
 molecular_functionGO:0004630 phospholipase D activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0035755 cardiolipin hydrolase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of PA


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Tcf7l2tm2.2Mrc/Tcf7l2tm2.2Mrc
Genetic Background: involves: 129S1/Sv

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003698 abnormal male reproductive system physiology "anomaly in the function of the male organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004884 abnormal testicular physiology "anomaly or loss either the production of male germ cells or the endocrine cells for the production testosterone" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Phc2tm1Hko/Phc2tm1Hko
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008878 abnormal DNA methylation during gametogenesis "any anomaly of the covalent transfer of a methyl group to C-5 of cytosine during gamete generation, when DNA methylation patterns are established" [GO:0043046]
Show

Allelic Composition: Pld6tm1.1Hsas/Pld6tm1.1Hsas
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000043648 Pld6 / Q5SWZ9 / Mitochondrial cardiolipin hydrolase / Q8N2A8* / phospholipase D family member 6*  / complex






 

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