ENSMUSG00000044792


Mus musculus

Features
Gene ID: ENSMUSG00000044792
  
Biological name :Isca1
  
Synonyms : Iron-sulfur cluster assembly 1 homolog, mitochondrial / Isca1 / Q9D924
  
Possible biological names infered from orthology : iron-sulfur cluster assembly 1 / Q9BUE6
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: B2
Gene start: 59755409
Gene end: 59769810
  
Corresponding Affymetrix probe sets: 10403934 (MoGene1.0st)   10409799 (MoGene1.0st)   1423651_at (Mouse Genome 430 2.0 Array)   1423652_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153175
Ensembl peptide - ENSMUSP00000054858
NCBI entrez gene - 69046     See in Manteia.
MGI - MGI:1916296
RefSeq - NM_026921
RefSeq Peptide - NP_081197
swissprot - A0A286YCW6
swissprot - Q9D924
Ensembl - ENSMUSG00000044792
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 isca1ENSDARG00000051956Danio rerio
 ISCA1ENSGALG00000012606Gallus gallus
 ISCA1ENSG00000135070Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AK157302 / cDNA sequence AK157302 / ISCA1* / Q9BUE6* / iron-sulfur cluster assembly 1*ENSMUSG0000007813999


Protein motifs (from Interpro)
Interpro ID Name
 IPR000361  FeS cluster biogenesis
 IPR016092  FeS cluster insertion protein
 IPR017870  FeS cluster insertion, C-terminal, conserved site
 IPR035903  HesB-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016226 iron-sulfur cluster assembly IBA
 biological_processGO:0097428 protein maturation by iron-sulfur cluster transfer IBA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005759 mitochondrial matrix IBA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0008198 ferrous iron binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051537 2 iron, 2 sulfur cluster binding IBA


Pathways (from Reactome)
Pathway description
Mitochondrial iron-sulfur cluster biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
Show

Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Fzd4tm1.1(KOMP)Vlcg/Fzd4tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fzd4tm1.1(KOMP)Vlcg/Ucd

 MP:0011275 abnormal behavioral response to light "unexpected change in the activity of an organism (in terms of movement, outward responses) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light" [GO:0009416, MGI:llw2]
Show

Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0013278 decreased fasted circulating glucose level "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Fzd4tm1.1(KOMP)Vlcg/Fzd4tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fzd4tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021102 Glrx5 / Q80Y14 / Glutaredoxin-related protein 5, mitochondrial / Q86SX6* / glutaredoxin 5*  / reaction
 ENSMUSG00000021241 Isca2 / Q9DCB8 / Iron-sulfur cluster assembly 2 homolog, mitochondrial / Q86U28* / iron-sulfur cluster assembly 2*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr