ENSDARG00000051956


Danio rerio

Features
Gene ID: ENSDARG00000051956
  
Biological name :isca1
  
Synonyms : iron-sulfur cluster assembly 1 / isca1 / Q4QRC6
  
Possible biological names infered from orthology : AK157302 / cDNA sequence AK157302 / Iron-sulfur cluster assembly 1 homolog, mitochondrial / Q9BUE6 / Q9D924
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 69426654
Gene end: 69437422
  
Corresponding Affymetrix probe sets: Dr.2723.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000068166
NCBI entrez gene - 573999     See in Manteia.
swissprot - Q4QRC6
ZFIN ID - ZDB-GENE-050626-94
Ensembl - ENSDARG00000051956
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ISCA1ENSGALG00000012606Gallus gallus
 ISCA1ENSG00000135070Homo sapiens
 AK157302ENSMUSG00000078139Mus musculus
 Isca1ENSMUSG00000044792Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000361  FeS cluster biogenesis
 IPR016092  FeS cluster insertion protein
 IPR017870  FeS cluster insertion, C-terminal, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006783 heme biosynthetic process IMP
 biological_processGO:0016226 iron-sulfur cluster assembly IBA
 biological_processGO:0097428 protein maturation by iron-sulfur cluster transfer IBA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005759 mitochondrial matrix IBA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0008198 ferrous iron binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051537 2 iron, 2 sulfur cluster binding IBA


Pathways (from Reactome)
Pathway description
Mitochondrial iron-sulfur cluster biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte decreased amount , abnormal
nucleate erythrocyte hemoglobin complex composition , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000043665 glrx5 / Q6PBM1 / glutaredoxin 5 homolog (S. cerevisiae) / Q86SX6* / Q80Y14* / glutaredoxin 5* / Glutaredoxin-related protein 5, mitochondrial *  / reaction






 

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