Manteia - Molecule gene

ENSMUSG00000045039

Mus musculus

Features

Gene ID:	ENSMUSG00000045039

Biological name :	Megf8

Synonyms :	Megf8 / Multiple epidermal growth factor-like domains protein 8 / P60882

Possible biological names infered from orthology :	multiple EGF like domains 8 / Q7Z7M0

Species:	Mus musculus

Chr. number:	7
Strand:	1
Band:	A3
Gene start:	25317164
Gene end:	25365917

Corresponding Affymetrix probe sets:	10551120 (MoGene1.0st) 1460586_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000122192 NCBI entrez gene - 269878 See in Manteia. MGI - MGI:2446294 RefSeq - NM_001160400 RefSeq - XM_017322286 RefSeq Peptide - NP_001153872 swissprot - P60882 Ensembl - ENSMUSG00000045039

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
megf8	ENSDARG00000079751	Danio rerio
MEGF8	ENSG00000105429	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Atrn / Q9WU60 / Attractin / O75882*	ENSMUSG00000027312	12
Atrnl1 / Q6A051 / Attractin-like protein 1 / Q5VV63* / attractin like 1*	ENSMUSG00000054843	12

Protein motifs (from Interpro)

Interpro ID	Name
IPR000152	EGF-type aspartate/asparagine hydroxylation site
IPR000742	EGF-like domain
IPR000859	CUB domain
IPR001881	EGF-like calcium-binding domain
IPR002049	Laminin EGF domain
IPR002165	Plexin repeat
IPR013032	EGF-like, conserved site
IPR015915	Kelch-type beta propeller
IPR016201	PSI domain
IPR018097	EGF-like calcium-binding, conserved site
IPR024731	EGF domain
IPR035914	Spermadhesin, CUB domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0003143	embryonic heart tube morphogenesis	IMP
biological_process	GO:0007368	determination of left/right symmetry	IMP
biological_process	GO:0010468	regulation of gene expression	IMP
biological_process	GO:0030326	embryonic limb morphogenesis	IMP
biological_process	GO:0030509	BMP signaling pathway	IGI
biological_process	GO:0035108	limb morphogenesis	IEA
biological_process	GO:0042074	cell migration involved in gastrulation	IEA
biological_process	GO:0045879	negative regulation of smoothened signaling pathway	IMP
biological_process	GO:0048704	embryonic skeletal system morphogenesis	IMP
biological_process	GO:0048842	positive regulation of axon extension involved in axon guidance	IMP
biological_process	GO:0055113	epiboly involved in gastrulation with mouth forming second	IEA
biological_process	GO:0060971	embryonic heart tube left/right pattern formation	IMP
biological_process	GO:0060972	left/right pattern formation	IMP
biological_process	GO:0060976	coronary vasculature development	IMP
biological_process	GO:0061371	determination of heart left/right asymmetry	IEA
biological_process	GO:0071907	determination of digestive tract left/right asymmetry	IMP
biological_process	GO:0097094	craniofacial suture morphogenesis	IEA
biological_process	GO:0097155	fasciculation of sensory neuron axon	IMP
cellular_component	GO:0005634	nucleus	IDA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0003674	molecular_function	ND
molecular_function	GO:0005509	calcium ion binding	IEA
molecular_function	GO:0005515	protein binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000060	delayed bone ossification	"late onset of the formation of bone" [J:40203]	Show Allelic Composition: Megf8^{Gt(G037A09)Wrst}/Megf8^m687Ddg Genetic Background: involves: 129S6/SvEvTac * C3H/He * C57BL/6 * C57BL/6J Allelic Composition: Megf8^{Gt(G037A09)Wrst}/Megf8^{Gt(G037A09)Wrst} Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0000111	cleft palate	"congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Tgm3^we/Tgm3^we-Bkr Genetic Background: involves: 129 * C57BL/10 * UW Allelic Composition: Megf8^b2b1702.2Clo/Megf8^b2b1702.2Clo Genetic Background: C57BL/6J-Megf8^b2b1702.2Clo
MP:0000284	double outlet right ventricle	"both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]	Show Allelic Composition: Megf8^b2b1702.2Clo/Megf8^b2b1702.2Clo Genetic Background: C57BL/6J-Megf8^b2b1702.2Clo
MP:0000286	abnormal mitral valve morphology	"malformation of the valve between the left atrium and the left ventricle of the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Megf8^tm1.1Ddg/Megf8^tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ Allelic Composition: Megf8^{Gt(G037A09)Wrst}/Megf8^{Gt(G037A09)Wrst} Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0000295	poorly developed ventricular trabeculae	"retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]	Show Allelic Composition: Megf8^hlb611/Megf8^hlb611 Genetic Background: involves: C57BL/6J * C3H/HeJ
MP:0000445	short snout	"reduced length of the anterior facial part of the muzzle" [J:53370]	Show Allelic Composition: Tgm3^we/Tgm3^we-Bkr Genetic Background: involves: 129 * C57BL/10 * UW Allelic Composition: Megf8^b2b1702.2Clo/Megf8^b2b1702.2Clo Genetic Background: C57BL/6J-Megf8^b2b1702.2Clo
MP:0000531	right pulmonary isomerism	"bilaterally symmetric right lung pattern (or altered asymmetric patterning of the lung)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:58530]	Show Allelic Composition: Il6^tm1Kopf/Il6^tm1Kopf,Inpp5d^tm1Rkh/Inpp5d^tm1Rkh Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Megf8^hlb611/Megf8^hlb611 Genetic Background: involves: C57BL/6J * C3H/HeJ Allelic Composition: Megf8^b2b1702.2Clo/Megf8^b2b1702.2Clo Genetic Background: C57BL/6J-Megf8^b2b1702.2Clo
MP:0000534	abnormal ureter morphology	"anomalous structure of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Il6^tm1Kopf/Il6^tm1Kopf,Inpp5d^tm1Rkh/Inpp5d^tm1Rkh Genetic Background: involves: 129 * C57BL/6
MP:0000562	polydactyly	"greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Il6^tm1Kopf/Il6^tm1Kopf,Inpp5d^tm1Rkh/Inpp5d^tm1Rkh Genetic Background: involves: 129 * C57BL/6
MP:0000572	abnormal autopod morphology	"malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Megf8^{Gt(G037A09)Wrst}/Megf8^m687Ddg Genetic Background: involves: 129S6/SvEvTac * C3H/He * C57BL/6 * C57BL/6J Allelic Composition: Megf8^{Gt(G037A09)Wrst}/Megf8^{Gt(G037A09)Wrst} Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0000598	abnormal liver morphology	"malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]	Show Allelic Composition: Il6^tm1Kopf/Il6^tm1Kopf,Inpp5d^tm1Rkh/Inpp5d^tm1Rkh Genetic Background: involves: 129 * C57BL/6
MP:0000644	dextrocardia	"cardiac apex pointing to the right as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Il6^tm1Kopf/Il6^tm1Kopf,Inpp5d^tm1Rkh/Inpp5d^tm1Rkh Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Megf8^hlb611/Megf8^hlb611 Genetic Background: involves: C57BL/6J * C3H/HeJ Allelic Composition: Megf8^b2b288Clo/Megf8^b2b288Clo Genetic Background: C57BL/6J-Megf8^b2b288Clo Allelic Composition: Megf8^b2b1702.2Clo/Megf8^b2b1702.2Clo Genetic Background: C57BL/6J-Megf8^b2b1702.2Clo
MP:0000650	mesocardia	"cardiac apex pointing to the middle as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Il6^tm1Kopf/Il6^tm1Kopf,Inpp5d^tm1Rkh/Inpp5d^tm1Rkh Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Megf8^hlb611/Megf8^hlb611 Genetic Background: involves: C57BL/6J * C3H/HeJ
MP:0000690	absent spleen	"missing organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:55583]	Show Allelic Composition: Il6^tm1Kopf/Il6^tm1Kopf,Inpp5d^tm1Rkh/Inpp5d^tm1Rkh Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Megf8^hlb611/Megf8^hlb611 Genetic Background: involves: C57BL/6J * C3H/HeJ
MP:0000694	spleen hypoplasia	"small size due to reduced cell number in the spleen" [J:43971]	Show Allelic Composition: Megf8^b2b1702.2Clo/Megf8^b2b1702.2Clo Genetic Background: C57BL/6J-Megf8^b2b1702.2Clo
MP:0000914	exencephaly	"neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Megf8^{Gt(G037A09)Wrst}/Megf8^m687Ddg Genetic Background: involves: 129S6/SvEvTac * C3H/He * C57BL/6 * C57BL/6J
MP:0001065	abnormal trigeminal nerve morphology	"malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]	Show Allelic Composition: Sema3a^m808Ddg/Sema3a^tm1Mcf Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6 Allelic Composition: Megf8^{Gt(G037A09)Wrst}/Megf8^m687Ddg Genetic Background: involves: 129S6/SvEvTac * C3H/He * C57BL/6 * C57BL/6J Allelic Composition: Megf8^tm1.1Ddg/Megf8^tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ
MP:0001073	abnormal glossopharyngeal nerve morphology	"malformed or misprojection of sensory and autonomic axons to the parotid gland, carotid body, posterior third of the tongue" [Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]	Show Allelic Composition: Megf8^tm1.1Ddg/Megf8^tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ
MP:0001074	abnormal vagus nerve morphology	"malformed or misprojection of autonomic, sensory and motor axons of the tenth cranial nerve to the pharynx, larynx, trachea, lungs, heart and GI tract" [Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]	Show Allelic Composition: Megf8^tm1.1Ddg/Megf8^tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ
MP:0001077	abnormal spinal nerve morphology	"any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Sema3a^m808Ddg/Sema3a^tm1Mcf Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6 Allelic Composition: Megf8^tm1.1Ddg/Megf8^tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Megf8^b2b1702.2Clo/Megf8^b2b1702.2Clo Genetic Background: C57BL/6J-Megf8^b2b1702.2Clo
MP:0001293	anophthalmia	"congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]	Show Allelic Composition: Tgm3^we/Tgm3^we-Bkr Genetic Background: involves: 129 * C57BL/10 * UW Allelic Composition: Megf8^b2b1702.2Clo/Megf8^b2b1702.2Clo Genetic Background: C57BL/6J-Megf8^b2b1702.2Clo
MP:0001297	microphthalmia	"reduced average size of the eyes" [J:18048]	Show Allelic Composition: Megf8^b2b1702.2Clo/Megf8^b2b1702.2Clo Genetic Background: C57BL/6J-Megf8^b2b1702.2Clo
MP:0001785	edema	"an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]	Show Allelic Composition: Megf8^{Gt(G037A09)Wrst}/Megf8^m687Ddg Genetic Background: involves: 129S6/SvEvTac * C3H/He * C57BL/6 * C57BL/6J Allelic Composition: Megf8^{Gt(G037A09)Wrst}/Megf8^{Gt(G037A09)Wrst} Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0001823	thymus hypoplasia	"small size due to reduced cell number in the thymus" [J:23255]	Show Allelic Composition: Megf8^b2b1702.2Clo/Megf8^b2b1702.2Clo Genetic Background: C57BL/6J-Megf8^b2b1702.2Clo
MP:0002624	abnormal tricuspid valve morphology	"malformation of the valve with three cusps located between the right atrium and the right ventricle of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Megf8^tm1.1Ddg/Megf8^tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ Allelic Composition: Megf8^{Gt(G037A09)Wrst}/Megf8^{Gt(G037A09)Wrst} Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0002639	micrognathia	"abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Tgm3^we/Tgm3^we-Bkr Genetic Background: involves: 129 * C57BL/10 * UW Allelic Composition: Megf8^b2b1702.2Clo/Megf8^b2b1702.2Clo Genetic Background: C57BL/6J-Megf8^b2b1702.2Clo
MP:0003052	omphalocele	"protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Megf8^b2b1702.2Clo/Megf8^b2b1702.2Clo Genetic Background: C57BL/6J-Megf8^b2b1702.2Clo
MP:0003105	abnormal heart atrium morphology	"structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Megf8^tm1.1Ddg/Megf8^tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ Allelic Composition: Megf8^{Gt(G037A09)Wrst}/Megf8^{Gt(G037A09)Wrst} Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0003342	accessory spleen	"the splenic tissue is divided into equal masses; often related to situs inversus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Il6^tm1Kopf/Il6^tm1Kopf,Inpp5d^tm1Rkh/Inpp5d^tm1Rkh Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Megf8^hlb611/Megf8^hlb611 Genetic Background: involves: C57BL/6J * C3H/HeJ
MP:0003446	renal hypoplasia	"decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Megf8^hlb611/Megf8^hlb611 Genetic Background: involves: C57BL/6J * C3H/HeJ
MP:0003632	abnormal nervous system morphology		Show Allelic Composition: Sema3a^m808Ddg/Sema3a^tm1Mcf Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6
MP:0003651	abnormal axon outgrowth	"defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]	Show Allelic Composition: Megf8^tm1.1Ddg/Megf8^tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ
MP:0003921	abnormal left ventricle morphology	"structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Megf8^hlb611/Megf8^hlb611 Genetic Background: involves: C57BL/6J * C3H/HeJ
MP:0004110	transposition of great arteries	"cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Il6^tm1Kopf/Il6^tm1Kopf,Inpp5d^tm1Rkh/Inpp5d^tm1Rkh Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Megf8^hlb611/Megf8^hlb611 Genetic Background: involves: C57BL/6J * C3H/HeJ Allelic Composition: Megf8^b2b1702.2Clo/Megf8^b2b1702.2Clo Genetic Background: C57BL/6J-Megf8^b2b1702.2Clo
MP:0004133	heterotaxia	"abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Megf8^hlb611/Megf8^hlb611 Genetic Background: involves: C57BL/6J * C3H/HeJ Allelic Composition: Megf8^b2b288Clo/Megf8^b2b288Clo Genetic Background: C57BL/6J-Megf8^b2b288Clo Allelic Composition: Megf8^b2b1702.2Clo/Megf8^b2b1702.2Clo Genetic Background: C57BL/6J-Megf8^b2b1702.2Clo
MP:0004158	right aortic arch	"the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Megf8^hlb611/Megf8^hlb611 Genetic Background: involves: C57BL/6J * C3H/HeJ
MP:0004190	abnormal direction of embryo turning	"axial rotation of the embryo in a direction other than the normal anticlockwise direction when viewed towards the caudal pole during the late primitive streak/early somite stage (Mus E8.5-E9.5); clockwise rotation is frequently associated with heart and visceral defects" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development"]	Show Allelic Composition: Il6^tm1Kopf/Il6^tm1Kopf,Inpp5d^tm1Rkh/Inpp5d^tm1Rkh Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Megf8^tm1.1Ddg/Megf8^tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ Allelic Composition: Megf8^{Gt(G037A09)Wrst}/Megf8^{Gt(G037A09)Wrst} Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0004252	abnormal direction of looping morphogenesis	"deviation from the normal rightward direction of cardiac looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Il6^tm1Kopf/Il6^tm1Kopf,Inpp5d^tm1Rkh/Inpp5d^tm1Rkh Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Megf8^tm1.1Ddg/Megf8^tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ Allelic Composition: Megf8^{Gt(G037A09)Wrst}/Megf8^{Gt(G037A09)Wrst} Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0004320	split sternum	"the appearance of an abnormal division in the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Megf8^tm1.1Ddg/Megf8^tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ Allelic Composition: Megf8^{Gt(G037A09)Wrst}/Megf8^{Gt(G037A09)Wrst} Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0004624	abnormal thoracic cage	"any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Megf8^tm1.1Ddg/Megf8^tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ Allelic Composition: Megf8^{Gt(G037A09)Wrst}/Megf8^{Gt(G037A09)Wrst} Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0006061	right atrial isomerism	"altered asymmetric patterning of the atria" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Megf8^hlb611/Megf8^hlb611 Genetic Background: involves: C57BL/6J * C3H/HeJ
MP:0006126	abnormal outflow tract development	"anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Il6^tm1Kopf/Il6^tm1Kopf,Inpp5d^tm1Rkh/Inpp5d^tm1Rkh Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Megf8^tm1.1Ddg/Megf8^tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ Allelic Composition: Megf8^{Gt(G037A09)Wrst}/Megf8^{Gt(G037A09)Wrst} Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0008816	petechiae	"very small blood spots or splotches that appear especially in skin as a result of localized hemorrhage" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Megf8^b2b1702.2Clo/Megf8^b2b1702.2Clo Genetic Background: C57BL/6J-Megf8^b2b1702.2Clo
MP:0009450	abnormal axon fasiculation	"anomaly in the process by which axons form into bundles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sema3a^m808Ddg/Sema3a^tm1Mcf Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6 Allelic Composition: Megf8^{Gt(G037A09)Wrst}/Megf8^m687Ddg Genetic Background: involves: 129S6/SvEvTac * C3H/He * C57BL/6 * C57BL/6J Allelic Composition: Megf8^tm1.1Ddg/Megf8^tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ Allelic Composition: Megf8^tm1.2Ddg/Megf8^tm1.2Ddg,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J
MP:0009743	preaxial polydactyly	"duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433]	Show Allelic Composition: Megf8^tm1.1Ddg/Megf8^tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ Allelic Composition: Megf8^{Gt(G037A09)Wrst}/Megf8^{Gt(G037A09)Wrst} Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0009798	abnormal ophthalmic nerve morphology	"any structural anomaly of the sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the orbit and its contents, the nasal cavity and the skin of the nose and forehead" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Sema3a^m808Ddg/Sema3a^tm1Mcf Genetic Background: involves: 129S4/SvJae * C3H/He * C57BL/6 Allelic Composition: Megf8^{Gt(G037A09)Wrst}/Megf8^m687Ddg Genetic Background: involves: 129S6/SvEvTac * C3H/He * C57BL/6 * C57BL/6J Allelic Composition: Megf8^tm1.1Ddg/Megf8^tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ Allelic Composition: Megf8^tm1.2Ddg/Megf8^tm1.2Ddg,H2afv^{Tg(Wnt1-cre)11Rth}/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J
MP:0009799	abnormal maxillary nerve morphology	"any structural anomaly of the sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the palate, upper teeth and gingiva, the skin between the palpebral fissure and the mouth, and from the nasal cavity and maxillary sinuses" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Megf8^tm1.1Ddg/Megf8^tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ
MP:0010402	ventricular septal defect	"abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]	Show Allelic Composition: Megf8^hlb611/Megf8^hlb611 Genetic Background: involves: C57BL/6J * C3H/HeJ Allelic Composition: Megf8^tm1.1Ddg/Megf8^tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ Allelic Composition: Megf8^{Gt(G037A09)Wrst}/Megf8^{Gt(G037A09)Wrst} Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0010403	atrial septal defect	"abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]	Show Allelic Composition: Megf8^hlb611/Megf8^hlb611 Genetic Background: involves: C57BL/6J * C3H/HeJ Allelic Composition: Megf8^tm1.1Ddg/Megf8^tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ Allelic Composition: Megf8^{Gt(G037A09)Wrst}/Megf8^{Gt(G037A09)Wrst} Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0010412	atrioventricular septal defect	"defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]	Show Allelic Composition: Megf8^b2b1702.2Clo/Megf8^b2b1702.2Clo Genetic Background: C57BL/6J-Megf8^b2b1702.2Clo
MP:0010413	complete atrioventricular septal defect	"a type of atrioventricular septal defect in which a single atrioventricular valve annulus, a common atrioventricular valve, and a defect of the inlet ventricular septum are observed; deficiency of the atrioventricular septum also results in the presence of a large primum atrial septal defect" [http://emedicine.medscape.com]	Show Allelic Composition: Megf8^hlb611/Megf8^hlb611 Genetic Background: involves: C57BL/6J * C3H/HeJ Allelic Composition: Megf8^b2b288Clo/Megf8^b2b288Clo Genetic Background: C57BL/6J-Megf8^b2b288Clo
MP:0010420	muscular ventricular septal defect	"abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]	Show Allelic Composition: Megf8^b2b1702.2Clo/Megf8^b2b1702.2Clo Genetic Background: C57BL/6J-Megf8^b2b1702.2Clo
MP:0010426	abnormal heart and great artery attachment	"any anomaly in the in the position or pattern of the connection site of the heart to any of the great arteries, including the pulmonary artery and aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Megf8^hlb611/Megf8^hlb611 Genetic Background: involves: C57BL/6J * C3H/HeJ
MP:0010437	absent coronary sinus	"absence of the short trunk that recieves most of the cardiac veins carrying the blood from the myocardium and delivers it to the right atrium" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Megf8^hlb611/Megf8^hlb611 Genetic Background: involves: C57BL/6J * C3H/HeJ
MP:0010440	anomalous pulmonary venous connection	"abnormal development and attachment of the four pulmonary veins that normally attach to the left atrium of the heart, resulting in either partial or complete anomalous drainage back into the systemic venous circulation via an anomalous connection to the right atrium, the superior or inferior vena cava, the innominate vein, the coronary sinus or the left subclavian artery" [http://emedicine.medscape.com]	Show Allelic Composition: Il6^tm1Kopf/Il6^tm1Kopf,Inpp5d^tm1Rkh/Inpp5d^tm1Rkh Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Megf8^hlb611/Megf8^hlb611 Genetic Background: involves: C57BL/6J * C3H/HeJ
MP:0010449	heart right ventricle outflow tract stenosis	"abnormal constriction or narrowing of part of the anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Megf8^tm1.1Ddg/Megf8^tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ Allelic Composition: Megf8^{Gt(G037A09)Wrst}/Megf8^{Gt(G037A09)Wrst} Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0010476	coronary fistula	"an abnormal communication between the terminus of a coronary artery, bypassing the myocardial capillary bed and entering either a chamber of the heart (coronary-cameral fistula) or any segment of the systemic or pulmonary circulation (coronary arteriovenous fistula)" [http://emedicine.medscape.com]	Show Allelic Composition: Megf8^b2b1702.2Clo/Megf8^b2b1702.2Clo Genetic Background: C57BL/6J-Megf8^b2b1702.2Clo
MP:0010807	abnormal stomach position or orientation	"the stomach is displaced from the normal left-sided position and/or orientation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Megf8^hlb611/Megf8^hlb611 Genetic Background: involves: C57BL/6J * C3H/HeJ
MP:0010808	right-sided stomach	"stomach is present on the right side of the body instead of the left" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Il6^tm1Kopf/Il6^tm1Kopf,Inpp5d^tm1Rkh/Inpp5d^tm1Rkh Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Megf8^b2b1702.2Clo/Megf8^b2b1702.2Clo Genetic Background: C57BL/6J-Megf8^b2b1702.2Clo
MP:0011099	complete lethality throughout fetal growth and development	"death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Megf8^tm1.1Ddg/Megf8^tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ Allelic Composition: Megf8^{Gt(G037A09)Wrst}/Megf8^{Gt(G037A09)Wrst} Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
MP:0011665	d-loop transposition of the great arteries	"complete transposition of the great arteries; the d- refers to the dextroposition of the bulboventricular loop (ie, the position of the right ventricle, which is on the right side); in addition, the aorta also tends to be on the right and anterior, and the great arteries are parallel rather than crossing" [PMID:17159076]	Show Allelic Composition: Megf8^b2b288Clo/Megf8^b2b288Clo Genetic Background: C57BL/6J-Megf8^b2b288Clo
MP:0011666	double outlet right ventricle, ventricular defect committed to aorta	"a form of DORV in which a ventricular septal defect is located just below the aorta; the left ventricular outflow is directed toward the aorta, resulting in aortic oxygen saturations that exceed pulmonary saturations; pulmonary stenosis is also often present" [MGI:csmith]	Show Allelic Composition: Megf8^b2b288Clo/Megf8^b2b288Clo Genetic Background: C57BL/6J-Megf8^b2b288Clo Allelic Composition: Megf8^b2b1702.2Clo/Megf8^b2b1702.2Clo Genetic Background: C57BL/6J-Megf8^b2b1702.2Clo
MP:0011668	double outlet right ventricle, Taussig bing type	"a form of DORV in which blood from the left ventricle passes through a ventricular septal defect to the pulmonary artery, and blood from the right ventricle is directed to the aorta" [MGI:csmith]	Show Allelic Composition: Megf8^b2b1702.2Clo/Megf8^b2b1702.2Clo Genetic Background: C57BL/6J-Megf8^b2b1702.2Clo
MP:0012531	delayed limb development	"late onset of the induction and/or differentiation of the limbs" [MGI:anna]	Show Allelic Composition: Megf8^tm1.1Ddg/Megf8^tm1.1Ddg Genetic Background: involves: 129S6/SvEvTac * BALB/cJ

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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