ENSMUSG00000027312


Mus musculus

Features
Gene ID: ENSMUSG00000027312
  
Biological name :Atrn
  
Synonyms : Atrn / Attractin / Q9WU60
  
Possible biological names infered from orthology : O75882
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: F1
Gene start: 130906495
Gene end: 131030333
  
Corresponding Affymetrix probe sets: 10476207 (MoGene1.0st)   10601612 (MoGene1.0st)   1421166_at (Mouse Genome 430 2.0 Array)   1434197_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028781
NCBI entrez gene - 11990     See in Manteia.
MGI - MGI:1341628
RefSeq - XM_011239259
RefSeq - NM_009730
RefSeq - XM_006498606
RefSeq Peptide - NP_033860
swissprot - Q9WU60
Ensembl - ENSMUSG00000027312
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atrnENSDARG00000062164Danio rerio
 ATRNENSGALG00000016034Gallus gallus
 ATRNENSG00000088812Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atrnl1 / Q6A051 / Attractin-like protein 1 / Q5VV63* / attractin like 1*ENSMUSG0000005484357
Megf8 / P60882 / Multiple epidermal growth factor-like domains protein 8 / Q7Z7M0* / multiple EGF like domains 8*ENSMUSG0000004503923


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR000859  CUB domain
 IPR001304  C-type lectin-like
 IPR002049  Laminin EGF domain
 IPR002165  Plexin repeat
 IPR006652  Kelch repeat type 1
 IPR011043  Galactose oxidase/kelch, beta-propeller
 IPR013032  EGF-like, conserved site
 IPR015915  Kelch-type beta propeller
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR016201  PSI domain
 IPR035914  Spermadhesin, CUB domain superfamily
 IPR037293  Galactose oxidase, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0021549 cerebellum development IMP
 biological_processGO:0040014 regulation of multicellular organism growth IMP
 biological_processGO:0042552 myelination IMP
 biological_processGO:0043473 pigmentation IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030246 carbohydrate binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Grm1tm1Crpl/Grm1tm1Crpl
Genetic Background: Not Specified

Allelic Composition: Atrnmg-6J/Atrnmg-6J
Genetic Background: involves: C3H/HeSnJ * CAST/Ei

Allelic Composition: Atrnmg-3J/Atrnmg-3J
Genetic Background: C3HeB/FeJ-Atrnmg-3J/J

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Atrnmg-6J/Atrnmg-6J
Genetic Background: involves: C3H/HeSnJ * CAST/Ei

 MP:0000832 abnormal thalamus morphology "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atrnmg-6J/Atrnmg-6J
Genetic Background: involves: C3H/HeSnJ * CAST/Ei

 MP:0000846 abnormal medulla oblongata "anomaly in the most caudal region of the brainstem that lies directly rostral to the spinal cord; includes regions responsible for autonomic functions such as digestion, breathing and control of heart rate" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Atrnmg-6J/Atrnmg-6J
Genetic Background: involves: C3H/HeSnJ * CAST/Ei

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Atrnmg-6J/Atrnmg-6J
Genetic Background: involves: C3H/HeSnJ * CAST/Ei

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atrnmg-3J/Atrnmg-3J,Atrnl1tm1Gsb/Atrnl1tm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C3HeB/FeJ

Allelic Composition: AtrnGt(PST112)Byg/AtrnGt(PST112)Byg,Tg(ACTB-Atrnl1)B4Tmg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atrnmg-3J/Atrn+,Pepddal/Pepddal
Genetic Background: involves: C3H/HeJ * C3HeB/FeJ * CBA/J

Allelic Composition: Atrnmg-3J/Atrn+,Pepddal/Pepd+
Genetic Background: involves: C3H/HeJ * C3HeB/FeJ * CBA/J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Atrnmg/Atrnmg
Genetic Background: C3H/HeJ.Cg-Atrnmg

Allelic Composition: Atrnmg-3J/Atrnmg-3J
Genetic Background: C3HeB/FeJ-Atrnmg-3J/J

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Grm1tm1Crpl/Grm1tm1Crpl
Genetic Background: Not Specified

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atrnmg/Atrnmg
Genetic Background: C3H/HeJ.Cg-Atrnmg

Allelic Composition: Atrnmg-3J/Atrnmg-3J
Genetic Background: C3HeB/FeJ-Atrnmg-3J/J

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atrnmg-6J/Atrnmg-6J
Genetic Background: involves: C3H/HeSnJ * CAST/Ei

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Reltm1Hcl/Reltm1Hcl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Atrnmg/Atrnmg
Genetic Background: C3H/HeJ.Cg-Atrnmg

Allelic Composition: Atrnmg-3J/Atrnmg-3J
Genetic Background: C3HeB/FeJ-Atrnmg-3J/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grm1tm1Crpl/Grm1tm1Crpl
Genetic Background: Not Specified

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atrnmg-3J/Atrnmg-3J
Genetic Background: C3HeB/FeJ-Atrnmg-3J/J

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Grm1tm1Crpl/Grm1tm1Crpl
Genetic Background: Not Specified

Allelic Composition: Atrnmg-3J/Atrnmg-3J
Genetic Background: C3HeB/FeJ-Atrnmg-3J/J

 MP:0002654 spongiform encephalopathy "a neurodegenerative state characterized by the appearance of large vacuolated areas in the brain cells, resembling a sponge" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atrnmg-3J/Atrnmg-3J
Genetic Background: C3HeB/FeJ-Atrnmg-3J/J

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Grm1tm1Crpl/Grm1tm1Crpl
Genetic Background: Not Specified

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atrnmg-3J/Atrnmg-3J
Genetic Background: C3HeB/FeJ-Atrnmg-3J/J

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
Show

Allelic Composition: Atrnmg-3J/Atrnmg-3J
Genetic Background: C3HeB/FeJ-Atrnmg-3J

 MP:0005409 darkened coat color "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is decreasesd when compared to wild-type agouti" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grm1tm1Crpl/Grm1tm1Crpl
Genetic Background: Not Specified

Allelic Composition: Atrnmg-6J/Atrnmg-6J
Genetic Background: involves: C3H/HeSnJ * CAST/Ei

Allelic Composition: Atrnmg-3J/Atrnmg-3J
Genetic Background: C3HeB/FeJ-Atrnmg-3J/J

Allelic Composition: Atrnmg/Atrnmg
Genetic Background: LDJ/Le

Allelic Composition: AtrnGt(PST112)Byg/AtrnGt(PST112)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Atrnmg-3J/Atrnmg-3J,Tg(ACTB-Atrnl1)B4Tmg/0
Genetic Background: involves: C3HeB/FeJ * C57BL/6 * DBA/2

Allelic Composition: AtrnGt(PST112)Byg/AtrnGt(PST112)Byg
Genetic Background: C3.129P2-AtrnGt(PST112)Byg

Allelic Composition: Atrnmg-3J/Atrn+,Pepddal/Pepddal
Genetic Background: involves: C3H/HeJ * C3HeB/FeJ * CBA/J

 MP:0008025 brain vacuoles "the abnormal presence of cavities or fluid-filled vesicles in the soma of brain cells, often indicative of spongiosis or other pathological states" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Reltm1Hcl/Reltm1Hcl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Atrnmg/Atrnmg
Genetic Background: C3H/HeJ.Cg-Atrnmg

Allelic Composition: Atrnmg-6J/Atrnmg-6J
Genetic Background: involves: C3H/HeSnJ * CAST/Ei

Allelic Composition: Atrnmg-3J/Atrnmg-3J
Genetic Background: C3HeB/FeJ-Atrnmg-3J/J

Allelic Composition: Atrnmg/Atrnmg
Genetic Background: LDJ/Le

Allelic Composition: Atrnmg-3J/Atrnmg-3J,Tg(ACTB-Atrnl1)B4Tmg/0
Genetic Background: involves: C3HeB/FeJ * C57BL/6 * DBA/2

Allelic Composition: Atrnmg-3J/Atrnmg-3J,Atrnl1tm1Gsb/Atrnl1tm1Gsb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * C3HeB/FeJ

Allelic Composition: AtrnGt(PST112)Byg/AtrnGt(PST112)Byg
Genetic Background: C3.129P2-AtrnGt(PST112)Byg

Allelic Composition: AtrnGt(PST112)Byg/AtrnGt(PST112)Byg,Tg(ACTB-Atrnl1)B4Tmg/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Allelic Composition: Atrnmg-3J/Atrn+,Pepddal/Pepddal
Genetic Background: involves: C3H/HeJ * C3HeB/FeJ * CBA/J

Allelic Composition: Atrnmg-3J/Atrnmg-3J
Genetic Background: involves: C3H/HeJ * C3HeB/FeJ * CBA/J

 MP:0008026 abnormal brain white matter morphology "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atrnmg-6J/Atrnmg-6J
Genetic Background: involves: C3H/HeSnJ * CAST/Ei

 MP:0008027 abnormal spinal cord white matter morphology "any structural anomaly of the regions of the spinal cord that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atrnmg-6J/Atrnmg-6J
Genetic Background: involves: C3H/HeSnJ * CAST/Ei

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atrnmg/Atrnmg
Genetic Background: C3H/HeJ.Cg-Atrnmg

Allelic Composition: Atrnmg-3J/Atrnmg-3J
Genetic Background: C3HeB/FeJ-Atrnmg-3J/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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