ENSMUSG00000045216


Mus musculus

Features
Gene ID: ENSMUSG00000045216
  
Biological name :Hs6st1
  
Synonyms : Heparan-sulfate 6-O-sulfotransferase 1 / Hs6st1 / Q9QYK5
  
Possible biological names infered from orthology : O60243
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: B
Gene start: 36068400
Gene end: 36106446
  
Corresponding Affymetrix probe sets: 10345442 (MoGene1.0st)   1417293_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000085499
NCBI entrez gene - 50785     See in Manteia.
MGI - MGI:1354958
RefSeq - NM_015818
RefSeq Peptide - NP_056633
swissprot - Q9QYK5
Ensembl - ENSMUSG00000045216
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A0MGZ5ENSDARG00000071501Danio rerio
 Q56UJ5ENSDARG00000054754Danio rerio
 HS6ST1ENSGALG00000002155Gallus gallus
 HS6ST1ENSG00000136720Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hs6st2 / Q80UW0 / Heparan-sulfate 6-O-sulfotransferase 2 / Q96MM7*ENSMUSG0000006218441
Hs6st3 / Q9QYK4 / Heparan-sulfate 6-O-sulfotransferase 3 / Q8IZP7*ENSMUSG0000005346540


Protein motifs (from Interpro)
Interpro ID Name
 IPR005331  Sulfotransferase
 IPR010635  Heparan sulphate 6-sulfotransferase/Protein-tyrosine sulfotransferase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0015012 heparan sulfate proteoglycan biosynthetic process IMP
 biological_processGO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification IDA
 biological_processGO:0048286 lung alveolus development IMP
 biological_processGO:0048666 neuron development IEA
 biological_processGO:0060716 labyrinthine layer blood vessel development IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0008146 sulfotransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017095 heparan sulfate 6-O-sulfotransferase activity IDA


Pathways (from Reactome)
Pathway description
HS-GAG biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myo5argsc11/Myo5argsc11
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0001183 overexpanded alveoli "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]
Show

Allelic Composition: Pkd1tm1Shh/Pkd1tm1Shh
Genetic Background: involves: 129P2/OlaHsd

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Pkd1tm1Shh/Pkd1tm1Shh
Genetic Background: involves: 129P2/OlaHsd

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Grem1tm1Azun/Grem1tm1Azun
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Grem1tm1Azun/Grem1tm1Azun
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grem1tm1Azun/Grem1tm1Azun
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Hs6st1tm1.1Wvc/Hs6st1tm1.1Wvc
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grem1tm1Azun/Grem1tm1Azun
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grem1tm1Azun/Grem1tm1Azun
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grem1tm1Azun/Grem1tm1Azun
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Grem1tm1Azun/Grem1tm1Azun
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005104 abnormal tarsus morphology "malformation or absence of any of the eight bones of the instep of the paw: tibiale, talus, calcaneus, navicular, 3 cuneiform, and cuboid bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
Show

Allelic Composition: Grem1tm1Azun/Grem1tm1Azun
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005241 abnormal retinal ganglion layer morphology "anomalous structure of the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005306 abnormal phalanx morphology "aberrant structure of any of the long bones of the digits" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Grem1tm1Azun/Grem1tm1Azun
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Hs6st1tm1.1Wvc/Hs6st1tm1.1Wvc
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Hs6st1tm1.1Wvc/Hs6st1tm1.1Wvc
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Hs6st1tm1Kkm/Hs6st1tm1Kkm
Genetic Background: involves: 129P2/OlaHsd * C3H/He

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Hs6st1tm1.1Wvc/Hs6st1tm1.1Wvc
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Grem1tm1Azun/Grem1tm1Azun
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Hs6st1tm1Kkm/Hs6st1tm1Kkm
Genetic Background: involves: 129P2/OlaHsd * C3H/He

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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