ENSMUSG00000046364


Mus musculus

Features
Gene ID: ENSMUSG00000046364
  
Biological name :Rpl27a
  
Synonyms : 60S ribosomal protein L27a / P14115 / Rpl27a
  
Possible biological names infered from orthology : P46776 / ribosomal protein L27a
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E3
Gene start: 109519147
Gene end: 109522367
  
Corresponding Affymetrix probe sets: 10357369 (MoGene1.0st)   10363479 (MoGene1.0st)   10406854 (MoGene1.0st)   10474669 (MoGene1.0st)   10487643 (MoGene1.0st)   10491062 (MoGene1.0st)   10547151 (MoGene1.0st)   10556200 (MoGene1.0st)   10556206 (MoGene1.0st)   10570432 (MoGene1.0st)   10578064 (MoGene1.0st)   1419799_at (Mouse Genome 430 2.0 Array)   1426661_at (Mouse Genome 430 2.0 Array)   1437729_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123410
Ensembl peptide - ENSMUSP00000134650
NCBI entrez gene - 26451     See in Manteia.
MGI - MGI:1347076
RefSeq - NM_011975
RefSeq Peptide - NP_036105
swissprot - G3UZV5
swissprot - P14115
Ensembl - ENSMUSG00000046364
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RPL27AENSGALG00000005948Gallus gallus
 P46776ENSG00000166441Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001196  Ribosomal protein L15, conserved site
 IPR021131  Ribosomal protein L18e/L15P
 IPR030878  Ribosomal protein L15
 IPR036227  Ribosomal L18e/L15P superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002181 cytoplasmic translation IBA
 biological_processGO:0006412 translation IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005840 ribosome IEA
 cellular_componentGO:0015934 large ribosomal subunit IEA
 cellular_componentGO:0022625 cytosolic large ribosomal subunit IBA
 molecular_functionGO:0003723 RNA binding IBA
 molecular_functionGO:0003735 structural constituent of ribosome IEA


Pathways (from Reactome)
Pathway description
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000575 dark foot pads "darker color of the foot pads due to excess pigment" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
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Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Rpl27aSfa/Rpl27a+,Trp53tm1Tyj/Trp53+
Genetic Background: B6.Cg-Rpl27aSfa Trp53tm1Tyj

Allelic Composition: Rpl27aSfa/Rpl27a+,Tg(Dct-lacZ)#Ove/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
Show

Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000873 thin external granule cell layer "reduced thickness of the transient layer of the cerebellar cortex which is composed of dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000885 ectopic Purkinje cell "Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, J:60896]
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Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001188 hyperpigmentation "excess of pigment in any or all tissues or a part of a tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Rpl27aSfa/Rpl27a+,Tg(Dct-lacZ)#Ove/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001272 increased metastatic potential 
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Allelic Composition: Rpl27aSfa/Rpl27a+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001658 increased mortality induced by gamma-irradiation "greater sensitivity to doses of ionizing radiation" [J:51834]
Show

Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002019 abnormal tumor incidence "deviation from the expected number of abnormal growths of a specific tissue in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rpl27aSfa/Rpl27aSfa,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rpl27aSfa/Rpl27a+,Tg(Dct-lacZ)#Ove/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005152 pancytopenia "reduction in the number of erythrocytes, all types of white blood cells, and platelets in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:20450]
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Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008924 decreased granule neuron number "reduction in the number of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
Show

Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009388 abnormal epidermal melanocyte morphology "any structural anomaly of the cells that produce pigment in the epidermis" [ISBN-13:978-1-4051-2034-0 "The Pigmentary System, Second Edition"]
Show

Allelic Composition: Rpl27aSfa/Rpl27a+,Tg(Dct-lacZ)#Ove/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0009828 delayed tumor appearance "later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Rpl27aSfa/Rpl27a+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

 MP:0009956 abnormal cerebellar layer morphology "any structural anomaly of the laminar structure of the cerebellar cortex comprising the gray matter of the cerebellum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010268 decreased lymphoma incidence "less than the expected number of neoplasms derived from lymphoid tissue in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rpl27aSfa/Rpl27a+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rpl27aSfa/Rpl27a+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Mdm2tm1Bay/Mdm2+,Rpl27aSfa/Rpl27a+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Mdm4tm1Glo/Mdm4+,Rpl27aSfa/Rpl27a+
Genetic Background: involves: C57BL/6J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Rpl27aSfa/Rpl27aSfa,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0011182 decreased hematopoietic cell number "fewer than expected number of cells of the hematopoietic lineage" [MGI:csmith]
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Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011276 increased tail pigmentation "visually detectable excess of pigment present on the tail surface" [MGI:csmith]
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Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Rpl27aSfa/Rpl27a+,Tg(Dct-lacZ)#Ove/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0011278 increased ear pigmentation "visually detectable excess of pigment present in the outer ear" [MGI:csmith]
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Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011902 increased hematopoietic stem cell proliferation "increase in the expansion rate of a hematopoietic stem cell population by cell division" [MGI:csmith]
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Allelic Composition: Tex19.1tm1(rtTA2S*M2,lacZ)Jw/Tex19.1tm1(rtTA2S*M2,lacZ)Jw
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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