ENSMUSG00000046733


Mus musculus

Features
Gene ID: ENSMUSG00000046733
  
Biological name :Gprc5a
  
Synonyms : Gprc5a / G protein-coupled receptor class C group 5 member A
  
Possible biological names infered from orthology : Q8NFJ5
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: G1
Gene start: 135065651
Gene end: 135084709
  
Corresponding Affymetrix probe sets: 10542335 (MoGene1.0st)   1437486_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000061062
NCBI entrez gene - 232431     See in Manteia.
MGI - MGI:1891250
RefSeq - NM_181444
RefSeq - XM_006506038
RefSeq Peptide - NP_852109
swissprot - G5E8C3
Ensembl - ENSMUSG00000046733
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000011796Gallus gallus
 GPRC5AENSG00000013588Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gprc5d / Q9JIL6 / G protein-coupled receptor, family C, group 5, member D / Q9NZD1* / G protein-coupled receptor class C group 5 member D*ENSMUSG0000003020544
Gprc5c / G protein-coupled receptor, family C, group 5, member C / Q9NQ84* / G protein-coupled receptor class C group 5 member C*ENSMUSG0000005104339
Gprc5b / Q923Z0 / G protein-coupled receptor, family C, group 5, member B / Q9NZH0* / G protein-coupled receptor class C group 5 member B*ENSMUSG0000000873435


Protein motifs (from Interpro)
Interpro ID Name
 IPR017978  GPCR family 3, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Tg(GFP/KRAS2/ALPP)1Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Tg(GFP/KRAS2/ALPP)1Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Tg(GFP/KRAS2/ALPP)1Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Ckmm-cre)5Khn/0,Tg(Myh6-Pik3ca)1Siz/0
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+,Tg(GFP/KRAS2/ALPP)1Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Gprc5atm1Rlo/Gprc5a+
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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