ENSMUSG00000008734


Mus musculus

Features
Gene ID: ENSMUSG00000008734
  
Biological name :Gprc5b
  
Synonyms : Gprc5b / G protein-coupled receptor, family C, group 5, member B / Q923Z0
  
Possible biological names infered from orthology : G protein-coupled receptor class C group 5 member B / Q9NZH0
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F2
Gene start: 118972047
Gene end: 118995211
  
Corresponding Affymetrix probe sets: 10567355 (MoGene1.0st)   1424613_at (Mouse Genome 430 2.0 Array)   1451411_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000008878
Ensembl peptide - ENSMUSP00000146777
NCBI entrez gene - 64297     See in Manteia.
MGI - MGI:1927596
RefSeq - NM_001195774
RefSeq - NM_022420
RefSeq Peptide - NP_001182703
RefSeq Peptide - NP_071865
swissprot - Q923Z0
swissprot - D2DFA9
Ensembl - ENSMUSG00000008734
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gprc5baENSDARG00000077080Danio rerio
 gprc5bbENSDARG00000075141Danio rerio
 GPRC5BENSGALG00000002028Gallus gallus
 GPRC5BENSG00000167191Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gprc5c / G protein-coupled receptor, family C, group 5, member C / Q9NQ84* / G protein-coupled receptor class C group 5 member C*ENSMUSG0000005104338
Gprc5a / G protein-coupled receptor class C group 5 member A / Q8NFJ5*ENSMUSG0000004673330
Gprc5d / Q9JIL6 / G protein-coupled receptor, family C, group 5, member D / Q9NZD1* / G protein-coupled receptor class C group 5 member D*ENSMUSG0000003020526


Protein motifs (from Interpro)
Interpro ID Name
 IPR017978  GPCR family 3, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007626 locomotory behavior IMP
 biological_processGO:0010976 positive regulation of neuron projection development IDA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0045666 positive regulation of neuron differentiation IMP
 biological_processGO:0045860 positive regulation of protein kinase activity IMP
 biological_processGO:0050729 positive regulation of inflammatory response IMP
 biological_processGO:0060907 positive regulation of macrophage cytokine production IMP
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IMP
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045121 membrane raft ISO
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0030295 protein kinase activator activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Prkab2tm1Grst/Prkab2tm1Grst,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gna11tm1b(EUCOMM)Wtsi/Gna11tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Gna11tm1b(EUCOMM)Wtsi/H

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prkab2tm1Grst/Prkab2tm1Grst,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0004931 enlarged epididymis "increase in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gna11tm1b(EUCOMM)Wtsi/Gna11tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Gna11tm1b(EUCOMM)Wtsi/H

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gna11tm1b(EUCOMM)Wtsi/Gna11tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Gna11tm1b(EUCOMM)Wtsi/H

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Prkab2tm1Grst/Prkab2tm1Grst,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Prkab2tm1Grst/Prkab2tm1Grst,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: C57BL/6 * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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