ENSMUSG00000046834


Mus musculus

Features
Gene ID: ENSMUSG00000046834
  
Biological name :Krt1
  
Synonyms : Keratin, type II cytoskeletal 1 / Krt1 / P04104
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F2
Gene start: 101845426
Gene end: 101850794
  
Corresponding Affymetrix probe sets: 10432852 (MoGene1.0st)   1422481_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023790
NCBI entrez gene - 16678     See in Manteia.
MGI - MGI:96698
RefSeq - NM_008473
RefSeq Peptide - NP_032499
swissprot - P04104
Ensembl - ENSMUSG00000046834
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Krt2 / Q3TTY5 / Keratin, type II cytoskeletal 2 epidermal / P35908* / keratin 2*ENSMUSG0000006420156
Krt77 / Q6IFZ6 / keratin 77 / Q7Z794*ENSMUSG0000006759448
Krt73 / Q6NXH9 / Keratin, type II cytoskeletal 73 / Q86Y46* / keratin 73*ENSMUSG0000006366146
Krt71 / Q9R0H5 / Keratin, type II cytoskeletal 71 ENSMUSG0000005187945
Krt72 / Q6IME9 / Keratin, type II cytoskeletal 72 / Q14CN4* / keratin 72*ENSMUSG0000005660543
Krt84 / Q99M73 / Keratin, type II cuticular Hb4 / Q9NSB2* / keratin 84*ENSMUSG0000004429440
Krt78 / keratin 78 / Q8N1N4*ENSMUSG0000005046336
Krt82 / Q99M74 / Keratin, type II cuticular Hb2 / Q9NSB4* / keratin 82*ENSMUSG0000004954834
Krt86 / P97861 / keratin 86 / KRT83* / KRT81* / O43790* / P78385* / Q14533* / keratin 83* / keratin 81*ENSMUSG0000006761433
Krt87 / Q6IMF0 / Keratin, type II cuticular 87 / KRT81* / KRT83* / KRT86* / O43790* / Q14533* / P78385* / keratin 81* / keratin 83* / keratin 86*ENSMUSG0000004764133
Krt83 / KRT81* / KRT86* / Q14533* / O43790* / P78385* / keratin 83* / keratin 81* / keratin 86*ENSMUSG0000006761332
Krt81 / Q9ERE2 / Keratin, type II cuticular Hb1 / KRT83* / KRT86* / P78385* / Q14533* / O43790* / keratin 81* / keratin 83* / keratin 86*ENSMUSG0000006761532
Krt80 / Q0VBK2 / Keratin, type II cytoskeletal 80 / Q6KB66* / keratin 80*ENSMUSG0000003718527


Protein motifs (from Interpro)
Interpro ID Name
 IPR001664  Intermediate filament protein
 IPR003054  Keratin, type II
 IPR018039  Intermediate filament protein, conserved site
 IPR032444  Keratin type II head
 IPR032449  Keratin type II cytoskeletal 1, tail


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001867 complement activation, lectin pathway ISO
 biological_processGO:0018149 peptide cross-linking ISO
 biological_processGO:0050728 negative regulation of inflammatory response IMP
 biological_processGO:0061436 establishment of skin barrier IMP
 cellular_componentGO:0001533 cornified envelope ISO
 cellular_componentGO:0005882 intermediate filament IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0031012 extracellular matrix HDA
 cellular_componentGO:0045095 keratin filament IDA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0030246 carbohydrate binding ISO
 molecular_functionGO:0030280 structural constituent of epidermis ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Upp1,-GFP)Gp/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001188 hyperpigmentation "excess of pigment in any or all tissues or a part of a tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: GarsGt(XM256)6Byg/GarsNmf249
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
Show

Allelic Composition: GarsGt(XM256)6Byg/GarsNmf249
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001208 blistering "accumulation of fluid- filled thin walled structures under the epidermis or within the epidermis" [J:65039]
Show

Allelic Composition: GarsGt(XM256)6Byg/GarsNmf249
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Krt1Mhdadsk12/Krt1Mhdadsk12
Genetic Background: C3HeB/FeJ-Krt1Mhdadsk12

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Krt1tm1Tmm/Krt1tm1Tmm,Krt10tm2Tmm/Krt10tm2Tmm
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0001230 epidermal desquamation "shedding of the cuticle of the epidermis in scales or shreds" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: GarsGt(XM256)6Byg/GarsNmf249
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001233 abnormal suprabasal layer morphology "malformed or atypical condition of the suprabasal layer of the skin" [J:56777]
Show

Allelic Composition: Krt1tm1Tmm/Krt1tm1Tmm,Krt10tm2Tmm/Krt10tm2Tmm
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: GarsGt(XM256)6Byg/GarsNmf249
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Krt1tm1Tmm/Krt1tm1Tmm,Krt10tm2Tmm/Krt10tm2Tmm
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Upp1,-GFP)Gp/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
Show

Allelic Composition: GarsGt(XM256)6Byg/GarsNmf249
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Upp1,-GFP)Gp/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0001874 acanthosis "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: GarsGt(XM256)6Byg/GarsNmf249
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Upp1,-GFP)Gp/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002095 abnormal skin pigmentation "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: GarsGt(XM256)6Byg/GarsNmf249
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002429 abnormal blood cell morphology/development "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Upp1,-GFP)Gp/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Upp1,-GFP)Gp/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Upp1,-GFP)Gp/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0003089 reduced skin tensile strength "reduction in the normal maximum tension the skin can withstand without tearing" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:48068]
Show

Allelic Composition: Krt1tm1Tmm/Krt1tm1Tmm,Krt10tm2Tmm/Krt10tm2Tmm
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Krt1tm1Tmm/Krt1+,Krt10tm2Tmm/Krt10tm2Tmm
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Krt1tm1Tmm/Krt1tm1Tmm,Krt10tm2Tmm/Krt10+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Upp1,-GFP)Gp/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0008588 abnormal circulating interleukin level "anomaly in the amount in the blood of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Upp1,-GFP)Gp/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0008635 increased circulating interleukin-18 level "increase in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity" [MESH:D12.644.276.374.465.518]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Upp1,-GFP)Gp/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0009594 abnormal corneocyte envelope morphology "any structural or developmental anomaly of the electron-dense layer of highly transglutaminase cross-linked protein that is deposited on the inner surface of the plasma membrane of corneocytes in the outermost layers of the epidermis; a monomolecular layer of ceramides is covalently attached to the outer surface of the CE to form a hydrophobic lipid envelope that covers each corneocyte and provides continuity with the lipid matrix" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Upp1,-GFP)Gp/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * FVB/N

Allelic Composition: Krt1tm1Tmm/Krt1tm1Tmm,Krt10tm2Tmm/Krt10tm2Tmm
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Krt1Mhdadsk12/Krt1Mhdadsk12
Genetic Background: C3HeB/FeJ-Krt1Mhdadsk12

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Krt1tm1Tmm/Krt1tm1Tmm,Krt10tm2Tmm/Krt10tm2Tmm
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Krt1tm1Tmm/Krt1+,Krt10tm2Tmm/Krt10tm2Tmm
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Krt1tm1Tmm/Krt1tm1Tmm,Krt10tm2Tmm/Krt10+
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-Upp1,-GFP)Gp/Gt(ROSA)26Sor+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0011400 complete lethality "all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2]
Show

Allelic Composition: Mboat7tm1Arai/Mboat7tm1Arai
Genetic Background: B6.129P2-Mboat7tm1Arai

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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