ENSMUSG00000064201


Mus musculus

Features
Gene ID: ENSMUSG00000064201
  
Biological name :Krt2
  
Synonyms : Keratin, type II cytoskeletal 2 epidermal / Krt2 / Q3TTY5
  
Possible biological names infered from orthology : keratin 2 / P35908
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F2
Gene start: 101810689
Gene end: 101818169
  
Corresponding Affymetrix probe sets: 10432840 (MoGene1.0st)   1427154_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023712
NCBI entrez gene - 16681     See in Manteia.
MGI - MGI:96699
RefSeq - NM_010668
RefSeq - XM_011245476
RefSeq Peptide - NP_034798
swissprot - Q3TTY5
Ensembl - ENSMUSG00000064201
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KRT2ENSG00000172867Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Krt1 / P04104 / Keratin, type II cytoskeletal 1 ENSMUSG0000004683450
Krt77 / Q6IFZ6 / keratin 77 / Q7Z794*ENSMUSG0000006759445
Krt73 / Q6NXH9 / Keratin, type II cytoskeletal 73 / Q86Y46* / keratin 73*ENSMUSG0000006366142
Krt71 / Q9R0H5 / Keratin, type II cytoskeletal 71 ENSMUSG0000005187941
Krt72 / Q6IME9 / Keratin, type II cytoskeletal 72 / Q14CN4* / keratin 72*ENSMUSG0000005660539
Krt84 / Q99M73 / Keratin, type II cuticular Hb4 / Q9NSB2* / keratin 84*ENSMUSG0000004429436
Krt78 / keratin 78 / Q8N1N4*ENSMUSG0000005046333
Krt82 / Q99M74 / Keratin, type II cuticular Hb2 / Q9NSB4* / keratin 82*ENSMUSG0000004954831
Krt83 / KRT81* / KRT86* / Q14533* / O43790* / P78385* / keratin 83* / keratin 81* / keratin 86*ENSMUSG0000006761329
Krt87 / Q6IMF0 / Keratin, type II cuticular 87 / KRT81* / KRT83* / KRT86* / O43790* / Q14533* / P78385* / keratin 81* / keratin 83* / keratin 86*ENSMUSG0000004764129
Krt81 / Q9ERE2 / Keratin, type II cuticular Hb1 / KRT83* / KRT86* / P78385* / Q14533* / O43790* / keratin 81* / keratin 83* / keratin 86*ENSMUSG0000006761529
Krt86 / P97861 / keratin 86 / KRT83* / KRT81* / O43790* / P78385* / Q14533* / keratin 83* / keratin 81*ENSMUSG0000006761429
Krt80 / Q0VBK2 / Keratin, type II cytoskeletal 80 / Q6KB66* / keratin 80*ENSMUSG0000003718525


Protein motifs (from Interpro)
Interpro ID Name
 IPR001664  Intermediate filament protein
 IPR003054  Keratin, type II
 IPR018039  Intermediate filament protein, conserved site
 IPR032444  Keratin type II head


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003334 keratinocyte development IMP
 biological_processGO:0008544 epidermis development IMP
 biological_processGO:0018149 peptide cross-linking IEA
 biological_processGO:0031424 keratinization IEA
 biological_processGO:0032980 keratinocyte activation IEA
 biological_processGO:0043616 keratinocyte proliferation IEA
 biological_processGO:0045109 intermediate filament organization IMP
 biological_processGO:0051546 keratinocyte migration IEA
 cellular_componentGO:0001533 cornified envelope IEA
 cellular_componentGO:0005882 intermediate filament IEA
 cellular_componentGO:0045095 keratin filament IDA
 molecular_functionGO:0005198 structural molecule activity IMP
 molecular_functionGO:0008092 cytoskeletal protein binding IMP
 molecular_functionGO:0030280 structural constituent of epidermis IEA


Pathways (from Reactome)
Pathway description
Keratinization
Formation of the cornified envelope


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000575 dark foot pads "darker color of the foot pads due to excess pigment" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ext1tm1Yama/Ext1+,Slit2tm1Matl/Slit2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Krt2Mhdadsk2/Krt2+
Genetic Background: C3HeB/FeJ-Krt2Mhdadsk2/Ieg

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
Show

Allelic Composition: Ext1tm1Yama/Ext1+,Slit2tm1Matl/Slit2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Krt2Mhdadsk2/Krt2+
Genetic Background: C3HeB/FeJ-Krt2Mhdadsk2/Ieg

Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi,Krt10tm2Tmm/Krt10tm2Tmm
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: Ext1tm1Yama/Ext1+,Slit2tm1Matl/Slit2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Krt2Mhdadsk2/Krt2+
Genetic Background: C3HeB/FeJ-Krt2Mhdadsk2/Ieg

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N

 MP:0001233 abnormal suprabasal layer morphology "malformed or atypical condition of the suprabasal layer of the skin" [J:56777]
Show

Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi,Krt10tm2Tmm/Krt10tm2Tmm
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N

Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Shank3tm1.2Yhj/Shank3tm1.2Yhj
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi,Krt10tm2Tmm/Krt10tm2Tmm
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N

 MP:0001874 acanthosis "diffuse hyperplasia of the spinous layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0002095 abnormal skin pigmentation "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ext1tm1Yama/Ext1+,Slit2tm1Matl/Slit2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Krt2Mhdadsk2/Krt2+
Genetic Background: C3HeB/FeJ-Krt2Mhdadsk2/Ieg

 MP:0002656 abnormal keratinocyte differentiation "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0009599 thick epidermis stratum granulosum "increased thickness of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0009600 hypergranulosis "increased thickness of the granular layer of the epidermis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi,Krt10tm2Tmm/Krt10tm2Tmm
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N

Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6N

 MP:0009675 orthokeratosis "thickening of the stratum corneum of the epidermis (hyperkeratosis) with non-nucleated keratinocytes retained in this layer" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Kdm8tm1b(EUCOMM)Wtsi/Kdm8tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kdm8tm1b(EUCOMM)Wtsi/Ics

 MP:0011276 increased tail pigmentation "visually detectable excess of pigment present on the tail surface" [MGI:csmith]
Show

Allelic Composition: Ext1tm1Yama/Ext1+,Slit2tm1Matl/Slit2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Krt2Mhdadsk2/Krt2+
Genetic Background: C3HeB/FeJ-Krt2Mhdadsk2/Ieg

 MP:0011278 increased ear pigmentation "visually detectable excess of pigment present in the outer ear" [MGI:csmith]
Show

Allelic Composition: Ext1tm1Yama/Ext1+,Slit2tm1Matl/Slit2tm1Matl,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S2/SvPas * 129S5/SvEvBrd * C57BL/6 * SJL

Allelic Composition: Krt2Mhdadsk2/Krt2+
Genetic Background: C3HeB/FeJ-Krt2Mhdadsk2/Ieg

Allelic Composition: Krt2tm1a(KOMP)Wtsi/Krt2tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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