ENSMUSG00000046865


Mus musculus

Features
Gene ID: ENSMUSG00000046865
  
Biological name :Fbl
  
Synonyms : Fbl / P35550 / rRNA 2-O-methyltransferase fibrillarin
  
Possible biological names infered from orthology : fibrillarin / P22087
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A3
Gene start: 28169710
Gene end: 28179269
  
Corresponding Affymetrix probe sets: 10447589 (MoGene1.0st)   10551464 (MoGene1.0st)   1416684_at (Mouse Genome 430 2.0 Array)   1416685_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146927
Ensembl peptide - ENSMUSP00000037613
NCBI entrez gene - 14113     See in Manteia.
MGI - MGI:95486
RefSeq - NM_007991
RefSeq Peptide - NP_032017
swissprot - A0A140LIR6
swissprot - P35550
Ensembl - ENSMUSG00000046865
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fblENSDARG00000053912Danio rerio
 FBLENSG00000105202Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fbll1 / Q80WS3 / rRNA/tRNA 2-O-methyltransferase fibrillarin-like protein 1 / A6NHQ2* / fibrillarin like 1*ENSMUSG0000005106275


Protein motifs (from Interpro)
Interpro ID Name
 IPR000692  Fibrillarin
 IPR020813  Fibrillarin, conserved site
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000494 box C/D snoRNA 3"-end processing IBA
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0008033 tRNA processing IEA
 biological_processGO:0016074 snoRNA metabolic process IMP
 biological_processGO:0031167 rRNA methylation IBA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0048254 snoRNA localization IEA
 biological_processGO:1990258 histone glutamine methylation IEA
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0001651 dense fibrillar component IEA
 cellular_componentGO:0001652 granular component IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0015030 Cajal body IEA
 cellular_componentGO:0031428 box C/D snoRNP complex IBA
 cellular_componentGO:0032040 small-subunit processome IBA
 molecular_functionGO:0001094 TFIID-class transcription factor binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008649 rRNA methyltransferase activity IBA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0051117 ATPase binding IEA
 molecular_functionGO:1990259 histone-glutamine methyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Major pathway of rRNA processing in the nucleolus and cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: X/Srydl1Rlb,Tg(Sry)2Ei/0
Genetic Background: involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: X/Srydl1Rlb,Tg(Sry)2Ei/0
Genetic Background: involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: X/Srydl1Rlb,Tg(Sry)2Ei/0
Genetic Background: involves: 129S6/SvEv * C3H * C57BL/6JEi * MF1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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