ENSMUSG00000048029


Mus musculus

Features
Gene ID: ENSMUSG00000048029
  
Biological name :Eno4
  
Synonyms : Eno4 / Enolase 4 / Q8C042
  
Possible biological names infered from orthology : A6NNW6 / enolase family member 4
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: D2
Gene start: 58943425
Gene end: 58971421
  
Corresponding Affymetrix probe sets: 10464342 (MoGene1.0st)   1444614_x_at (Mouse Genome 430 2.0 Array)   1457693_a_at (Mouse Genome 430 2.0 Array)   1457694_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000062584
Ensembl peptide - ENSMUSP00000144656
Ensembl peptide - ENSMUSP00000144272
Ensembl peptide - ENSMUSP00000143831
NCBI entrez gene - 226265     See in Manteia.
MGI - MGI:2441717
RefSeq - XM_006527054
RefSeq - XM_006527056
RefSeq - XM_006527055
RefSeq - NM_178689
RefSeq Peptide - NP_848804
swissprot - Q8C042
swissprot - A0A0J9YVG9
swissprot - A0A0J9YTS7
swissprot - A0A0J9YUP0
Ensembl - ENSMUSG00000048029
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eno4ENSDARG00000070598Danio rerio
 ENO4ENSGALG00000009254Gallus gallus
 ENO4ENSG00000188316Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eno3 / P21550 / Beta-enolase / P13929* / enolase 3*ENSMUSG0000006060018
Eno2 / P17183 / Gamma-enolase / P09104* / enolase 2*ENSMUSG0000000426718
Eno1b / P17182 / enolase 1B, retrotransposed / ENO1* / P06733* / enolase 1*ENSMUSG0000005904017
Eno1 / P17182 / Alpha-enolase / P06733* / enolase 1*ENSMUSG0000006352417


Protein motifs (from Interpro)
Interpro ID Name
 IPR000941  Enolase
 IPR020810  Enolase, C-terminal TIM barrel domain
 IPR020811  Enolase, N-terminal
 IPR029017  Enolase-like, N-terminal
 IPR036849  Enolase-like, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006096 glycolytic process IMP
 biological_processGO:0030317 flagellated sperm motility IMP
 biological_processGO:0044782 cilium organization IMP
 cellular_componentGO:0000015 phosphopyruvate hydratase complex IEA
 cellular_componentGO:0097228 sperm principal piece IDA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004634 phosphopyruvate hydratase activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6 * CD-1

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6 * CD-1

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6 * CD-1

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6 * CD-1

 MP:0004929 decreased epididymis weight "reduction in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6 * CD-1

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
Show

Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6 * CD-1

 MP:0009237 kinked sperm flagellum "a sharp bend or zigzag in the sperm tail" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6 * CD-1

 MP:0009831 abnormal sperm midpiece morphology "any structural abnormality of the highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece" [PMID:14581499]
Show

Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6 * CD-1

 MP:0009834 abnormal sperm annulus morphology "any structural anomaly of the ring-like, filamentous structure located at the distal end of the midpiece of the sperm flagellum; the annulus is thought to form a diffusion barrier between the midpiece and the principal piece and serve as a stabilizing structure for tail rigidity" [PMID:14581499]
Show

Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6 * CD-1

 MP:0009835 absent sperm annulus "absence of the ring-like, filamentous structure located at the midpiece-principal piece junction of the sperm flagellum, usually associated with a bent tail morphology" [PMID:14581499]
Show

Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6 * CD-1

 MP:0009836 abnormal sperm principal piece morphology "any structural abnormality in the segment of the sperm flagellum where the mitochondrial sheath ends and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs; the principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece" [PMID:14581499]
Show

Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6 * CD-1

 MP:0009838 abnormal sperm axoneme morphology "any structural abnormality of the central core of the sperm flagellum, composed of a ring of 9 outer microtubule doublets surrounding a central pair; inner and outer dynein arms project from each of the outer 9 doublets, and these arms are responsible for generating the motive force of the flagellum; in addition, 9 radial spokes, each of which originates from 1 of the 9 outer microtubular doublet pairs, project inward toward the central pair in a helical fashion" [PMID:14581499]
Show

Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6 * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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