ENSMUSG00000004267


Mus musculus

Features
Gene ID: ENSMUSG00000004267
  
Biological name :Eno2
  
Synonyms : Eno2 / Gamma-enolase / P17183
  
Possible biological names infered from orthology : enolase 2 / P09104
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F2
Gene start: 124760053
Gene end: 124769673
  
Corresponding Affymetrix probe sets: 10547807 (MoGene1.0st)   1418829_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114500
Ensembl peptide - ENSMUSP00000145216
Ensembl peptide - ENSMUSP00000145131
Ensembl peptide - ENSMUSP00000144861
Ensembl peptide - ENSMUSP00000144854
Ensembl peptide - ENSMUSP00000144698
Ensembl peptide - ENSMUSP00000119112
Ensembl peptide - ENSMUSP00000004378
Ensembl peptide - ENSMUSP00000108095
NCBI entrez gene - 13807     See in Manteia.
MGI - MGI:95394
RefSeq - XM_006505504
RefSeq - NM_001302642
RefSeq - NM_013509
RefSeq - XM_006505503
RefSeq Peptide - NP_001342149
RefSeq Peptide - NP_038537
RefSeq Peptide - NP_001289571
swissprot - D3Z6E4
swissprot - P17183
swissprot - D3YVD3
swissprot - A0A0N4SUX5
swissprot - A0A0N4SUI6
swissprot - A0A0N4SUW8
swissprot - D3Z2S4
swissprot - Q545V3
Ensembl - ENSMUSG00000004267
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eno2ENSDARG00000014287Danio rerio
 ENO2ENSGALG00000014528Gallus gallus
 ENO2ENSG00000111674Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eno1 / P17182 / Alpha-enolase / P06733* / enolase 1*ENSMUSG0000006352483
Eno3 / P21550 / Beta-enolase / P13929* / enolase 3*ENSMUSG0000006060083
Eno1b / P17182 / enolase 1B, retrotransposed / ENO1* / P06733* / enolase 1*ENSMUSG0000005904083
Eno4 / Q8C042 / Enolase 4 / A6NNW6* / enolase family member 4*ENSMUSG0000004802926


Protein motifs (from Interpro)
Interpro ID Name
 IPR000941  Enolase
 IPR020809  Enolase, conserved site
 IPR020810  Enolase, C-terminal TIM barrel domain
 IPR020811  Enolase, N-terminal
 IPR029017  Enolase-like, N-terminal
 IPR034390  Enolase-like superfamily
 IPR036849  Enolase-like, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006096 glycolytic process IEA
 cellular_componentGO:0000015 phosphopyruvate hydratase complex IEA
 cellular_componentGO:0001917 photoreceptor inner segment IDA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0043204 perikaryon IDA
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004634 phosphopyruvate hydratase activity IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Glycolysis
Gluconeogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Eno2tm1(DTA)Hsak/Eno2tm1(DTA)Hsak,Tg(Nes-cre/ERT2)4Kag/0
Genetic Background: involves: C57BL/6

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
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Allelic Composition: Kcnn2m1Btlr/Kcnn2m1Btlr
Genetic Background: C57BL/6J-Kcnn2m1Btlr

Allelic Composition: Eno2tm1(DTA)Hsak/Eno2tm1(DTA)Hsak,Tg(Nes-cre/ERT2)4Kag/0
Genetic Background: involves: C57BL/6

 MP:0000897 abnormal midbrain "malformation or malfunction associated with the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions, including eye movement and coordination of auditory and visual reflexes" [J:23882, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Eno2tm1(DTA)Hsak/Eno2+,Tg(Gpr151-cre)#Ito/0
Genetic Background: involves: C57BL/6

 MP:0001003 abnormal olfactory receptor morphology "anomalous structure of the specialized proteins within the neurons of the olfactory epithelium that normally bind and detect odorants " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tyrc-a/Tyrc-a
Genetic Background: C3H/HeJ-Tyrc-a/J

Allelic Composition: Eno2tm1(DTA)Hsak/?,Tg(Olfr16-cre,-ECFP)1Hsak/?
Genetic Background: involves: C57BL/6

 MP:0001038 abnormal cholinergic neuron morphology "malformation or absence of the neurons that utilize acetylcholine as a neurotransmitter " [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Eno2tm1(DTA)Hsak/Eno2+,Tg(Gpr151-cre)#Ito/0
Genetic Background: involves: C57BL/6

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Hmgn5tm1.1Mbus/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Tyrc-p/Tyrc-p
Genetic Background: involves: AKR/J * DBA/2J

Allelic Composition: Eno2tm1(DTA)Hsak/Eno2+,Tg(Gpr151-cre)#Ito/0
Genetic Background: involves: C57BL/6

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Tyrc-p/Tyrc-p
Genetic Background: involves: AKR/J * DBA/2J

 MP:0001460 abnormal olfactory -discrimination memory "defects in the ability to exhibit a differential response to olfactory stimuli that is achieved by the reinforcement of the desired response for each particular olfactory stimulus" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Tyrc-a/Tyrc-a
Genetic Background: C3H/HeJ-Tyrc-a/J

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Kcnn2m1Btlr/Kcnn2m1Btlr
Genetic Background: C57BL/6J-Kcnn2m1Btlr

 MP:0001984 abnormal olfaction "change in the ability to smell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tyrc-a/Tyrc-a
Genetic Background: C3H/HeJ-Tyrc-a/J

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tyrc-p/Tyrc-p
Genetic Background: involves: AKR/J * DBA/2J

 MP:0002067 abnormal sensory capabilities/reflexes/nociception "inability or altered ability to respond to a sensory stimulus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tyrc-a/Tyrc-a
Genetic Background: C3H/HeJ-Tyrc-a/J

Allelic Composition: Eno2tm1(DTA)Hsak/?,Tg(Olfr16-cre,-ECFP)1Hsak/?
Genetic Background: involves: C57BL/6

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Tyrc-p/Tyrc-p
Genetic Background: involves: AKR/J * DBA/2J

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Tyrc-p/Tyrc-p
Genetic Background: involves: AKR/J * DBA/2J

 MP:0004082 abnormal habenula development "anomaly in the group of nuclei that makes up the small eminence on the dorsomedial surface of the thalamus, just in front of the dorsal commissure on the lateral edge of the habenular trigone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Eno2tm1(DTA)Hsak/Eno2+,Tg(Gpr151-cre)#Ito/0
Genetic Background: involves: C57BL/6

 MP:0006092 abnormal olfactory neuron morphology "malformation in the neurons that are activated by specific odorants" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92950]
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Allelic Composition: Tyrc-a/Tyrc-a
Genetic Background: C3H/HeJ-Tyrc-a/J

Allelic Composition: Eno2tm1(DTA)Hsak/?,Tg(Olfr16-cre,-ECFP)1Hsak/?
Genetic Background: involves: C57BL/6

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Eno2tm1(DTA)Hsak/Eno2+,Tg(Gpr151-cre)#Ito/0
Genetic Background: involves: C57BL/6

 MP:0008432 abnormal long-term spatial reference memory "anomaly in long-term memory for spatial location information that is consolidated over hours and days after training or an encounter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Eno2tm1(DTA)Hsak/Eno2tm1(DTA)Hsak,Tg(Nes-cre/ERT2)4Kag/0
Genetic Background: involves: C57BL/6

 MP:0008462 abnormal medium spiny neuron morphology "any structural anomaly of the inhibitory projection neurons located in the striatum that integrate glutamatergic signals arising from the cerebral cortex and thalamus" [PMID:15504319]
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Allelic Composition: Tyrc-p/Tyrc-p
Genetic Background: involves: AKR/J * DBA/2J

 MP:0008924 decreased granule neuron number "reduction in the number of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
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Allelic Composition: Kcnn2m1Btlr/Kcnn2m1Btlr
Genetic Background: C57BL/6J-Kcnn2m1Btlr

Allelic Composition: Eno2tm1(DTA)Hsak/Eno2tm1(DTA)Hsak,Tg(Nes-cre/ERT2)4Kag/0
Genetic Background: involves: C57BL/6

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Kcnn2m1Btlr/Kcnn2m1Btlr
Genetic Background: C57BL/6J-Kcnn2m1Btlr

Allelic Composition: Eno2tm1(DTA)Hsak/Eno2tm1(DTA)Hsak,Tg(Nes-cre/ERT2)4Kag/0
Genetic Background: involves: C57BL/6

Allelic Composition: Eno2tm1(DTA)Hsak/Eno2+,Tg(Gpr151-cre)#Ito/0
Genetic Background: involves: C57BL/6

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Eno2tm1(DTA)Hsak/Eno2+,Tg(Gpr151-cre)#Ito/0
Genetic Background: involves: C57BL/6

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tyrc-p/Tyrc-p
Genetic Background: involves: AKR/J * DBA/2J

 MP:0009756 impaired behavioral response to nicotine "decreased sensitivity to nicotine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Eno2tm1(DTA)Hsak/Eno2+,Tg(Gpr151-cre)#Ito/0
Genetic Background: involves: C57BL/6

 MP:0010698 abnormal impulsive behavior control "any anomaly in the ability of an individual to exert restraint over behavior" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Eno2tm1(DTA)Hsak/Eno2+,Tg(Gpr151-cre)#Ito/0
Genetic Background: involves: C57BL/6

 MP:0011620 abnormal habituation to a new environment "anomaly in the process in which there is a progressive decline of behavioral response probability with an exposure to a new environment" [MGI:csmith]
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Allelic Composition: Eno2tm1(DTA)Hsak/Eno2+,Tg(Gpr151-cre)#Ito/0
Genetic Background: involves: C57BL/6

 MP:0012307 impaired spatial learning "impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
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Allelic Composition: Eno2tm1(DTA)Hsak/Eno2+,Tg(Gpr151-cre)#Ito/0
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004267 Eno2 / P17183 / Gamma-enolase / P09104* / enolase 2*  / complex






 

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