ENSMUSG00000063524


Mus musculus

Features
Gene ID: ENSMUSG00000063524
  
Biological name :Eno1
  
Synonyms : Alpha-enolase / Eno1 / P17182
  
Possible biological names infered from orthology : enolase 1 / P06733
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: E2
Gene start: 150236721
Gene end: 150248879
  
Corresponding Affymetrix probe sets: 10455595 (MoGene1.0st)   10473240 (MoGene1.0st)   10510546 (MoGene1.0st)   1419022_a_at (Mouse Genome 430 2.0 Array)   1419023_x_at (Mouse Genome 430 2.0 Array)   1427404_x_at (Mouse Genome 430 2.0 Array)   1431111_at (Mouse Genome 430 2.0 Array)   1432829_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000079727
Ensembl peptide - ENSMUSP00000123695
Ensembl peptide - ENSMUSP00000120059
Ensembl peptide - ENSMUSP00000114361
Ensembl peptide - ENSMUSP00000079045
NCBI entrez gene - 13806     See in Manteia.
MGI - MGI:95393
RefSeq - NM_023119
RefSeq - XM_017319953
RefSeq - XM_006538525
RefSeq Peptide - NP_075608
swissprot - B1ARR7
swissprot - P17182
swissprot - Q5FW97
swissprot - Q6PHC1
swissprot - B0QZL1
swissprot - B1ARR6
Ensembl - ENSMUSG00000063524
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eno1aENSDARG00000022456Danio rerio
 eno1bENSDARG00000013750Danio rerio
 ENO1ENSG00000074800Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eno1b / P17182 / enolase 1B, retrotransposed / ENO1* / P06733* / enolase 1*ENSMUSG00000059040100
Eno3 / P21550 / Beta-enolase / P13929* / enolase 3*ENSMUSG0000006060084
Eno2 / P17183 / Gamma-enolase / P09104* / enolase 2*ENSMUSG0000000426783
Eno4 / Q8C042 / Enolase 4 / A6NNW6* / enolase family member 4*ENSMUSG0000004802924


Protein motifs (from Interpro)
Interpro ID Name
 IPR000941  Enolase
 IPR020809  Enolase, conserved site
 IPR020810  Enolase, C-terminal TIM barrel domain
 IPR020811  Enolase, N-terminal
 IPR029017  Enolase-like, N-terminal
 IPR034390  Enolase-like superfamily
 IPR036849  Enolase-like, C-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0006096 glycolytic process IEA
 biological_processGO:0051099 positive regulation of binding IMP
 cellular_componentGO:0000015 phosphopyruvate hydratase complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0019897 extrinsic component of plasma membrane IDA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0099738 cell cortex region ISO
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0003723 RNA binding IDA
 molecular_functionGO:0004634 phosphopyruvate hydratase activity IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0045296 cadherin binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0051020 GTPase binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000063524 Eno1 / P17182 / Alpha-enolase / P06733* / enolase 1*  / complex






 

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contact: otassy@igbmc.fr