ENSMUSG00000049553


Mus musculus

Features
Gene ID: ENSMUSG00000049553
  
Biological name :Polr1a
  
Synonyms : DNA-directed RNA polymerase I subunit RPA1 / O35134 / Polr1a
  
Possible biological names infered from orthology : O95602 / RNA polymerase I subunit A
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: C1
Gene start: 71909053
Gene end: 71984935
  
Corresponding Affymetrix probe sets: 10539042 (MoGene1.0st)   1417775_at (Mouse Genome 430 2.0 Array)   1447597_at (Mouse Genome 430 2.0 Array)   1447598_x_at (Mouse Genome 430 2.0 Array)   1456066_a_at (Mouse Genome 430 2.0 Array)   1460215_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000060858
Ensembl peptide - ENSMUSP00000146166
Ensembl peptide - ENSMUSP00000146050
Ensembl peptide - ENSMUSP00000145553
NCBI entrez gene - 20019     See in Manteia.
MGI - MGI:1096397
RefSeq - XM_006505804
RefSeq - NM_009088
RefSeq Peptide - NP_033114
swissprot - A0A0U1RPM9
swissprot - A0A0U1RPX8
swissprot - O35134
swissprot - A0A0U1RNG3
Ensembl - ENSMUSG00000049553
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 polr1aENSDARG00000098375Danio rerio
 POLR1AENSGALG00000038160Gallus gallus
 O95602ENSG00000068654Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000722  RNA polymerase, alpha subunit
 IPR006592  RNA polymerase, N-terminal
 IPR007066  RNA polymerase Rpb1, domain 3
 IPR007080  RNA polymerase Rpb1, domain 1
 IPR007081  RNA polymerase Rpb1, domain 5
 IPR007083  RNA polymerase Rpb1, domain 4
 IPR015699  DNA-directed RNA pol I, largest subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000183 chromatin silencing at rDNA TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006360 transcription by RNA polymerase I IEA
 biological_processGO:1904750 negative regulation of protein localization to nucleolus IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005736 DNA-directed RNA polymerase I complex IDA
 molecular_functionGO:0001054 RNA polymerase I activity IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003899 DNA-directed 5"-3" RNA polymerase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016779 nucleotidyltransferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
B-WICH complex positively regulates rRNA expression
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase I Chain Elongation
RNA Polymerase I Transcription Termination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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