ENSMUSG00000050332


Mus musculus

Features
Gene ID: ENSMUSG00000050332
  
Biological name :Amer1
  
Synonyms : Amer1 / APC membrane recruitment protein 1 / Q7TS75
  
Possible biological names infered from orthology : Q5JTC6
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: C3
Gene start: 95420318
Gene end: 95444872
  
Corresponding Affymetrix probe sets: 10605811 (MoGene1.0st)   1439565_at (Mouse Genome 430 2.0 Array)   1453774_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109502
NCBI entrez gene - 72345     See in Manteia.
MGI - MGI:1919595
RefSeq - NM_175179
RefSeq Peptide - NP_780388
swissprot - Q7TS75
Ensembl - ENSMUSG00000050332
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 amer1ENSDARG00000079624Danio rerio
 AMER1ENSGALG00000007599Gallus gallus
 AMER1ENSG00000184675Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Amer2 / APC membrane recruitment protein 2 / Q8N7J2*ENSMUSG0000002198613
Amer3 / Q6NS69 / APC membrane recruitment protein 3 / Q8N944*ENSMUSG0000004517412


Protein motifs (from Interpro)
Interpro ID Name
 IPR019003  APC membrane recruitment protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination IEA
 biological_processGO:0060348 bone development IMP
 biological_processGO:0060612 adipose tissue development IMP
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0072161 mesenchymal cell differentiation involved in kidney development IMP
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:1903364 positive regulation of cellular protein catabolic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IEA
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:1904713 beta-catenin destruction complex binding IEA


Pathways (from Reactome)
Pathway description
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Disassembly of the destruction complex and recruitment of AXIN to the membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Amer1tm1.2Nbar/Amer1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

Allelic Composition: Amer1tm1.1Nbar/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0000439 enlarged skull 
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0000441 wide skull 
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0000552 abnormal radius morphology "malformation of the short bone of the lateral forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Amer1tm1.1Nbar/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0002835 abnormal cranial suture morphology "defects of the fibrous joint in the bones of the head" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:62161]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0003419 delayed endochondral bone ossification "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0003420 delayed intramembranous bone ossification "late onset of bone formation in bones that form without a cartilagenous intermediate including the cranium and clavicle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0003604 single kidney 
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

Allelic Composition: Amer1tm1.1Nbar/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Amer1tm1.1Nbar/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Amer1tm1.1Nbar/Y,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

 MP:0003797 abnormal compact bone morphology "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

Allelic Composition: Amer1tm1.1Nbar/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0003827 abnormal Wolffian duct morphology "malformation of the transient embryonic tubes that empty into the cloca and degenerate in the male " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0004199 enlarged fetal size "larger proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

Allelic Composition: Amer1tm1.2Nbar/Amer1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

 MP:0004353 abnormal deltoid tuberosity morphology "any structural anomaly of a rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

Allelic Composition: Amer1tm1.1Nbar/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0004354 absent deltoid tuberosity "missing the rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0004361 bowed ulna "increased curvature of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0004374 bowed radius "increased curvature of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0004988 increased osteoblast cell number "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amer1tm1.1Nbar/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Amer1tm1.1Nbar/Y,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

 MP:0005108 abnormal ulna morphology "malformation of the medial and larger of the two bones of the forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0005422 osteosclerosis "abnormal hardening or eburnation (change in exposed subchondral bone in degenerative joint disease in which bone is converted into a dense substance with a smooth surface) of bone " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathy M Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

Allelic Composition: Amer1tm1.1Nbar/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Amer1tm1.1Nbar/Y,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0006032 abnormal ureteric bud morphology "anomaly in the formation or development of the ureteric bud that with the metanephric mesenchyme gives rise to the kidneys " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0008272 abnormal endochondral bone ossification "anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0008273 abnormal intramembranous bone ossification "anomaly in the process of the formation of bone in which osteoblasts secrete a collage-proteoglycan matrix that binds calcium salts and becomes calcified; intramembranous ossification is the way flat bones are formed" [GO:0001957]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0008277 abnormal sternum ossification "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

Allelic Composition: Amer1tm1.1Nbar/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0008395 abnormal osteoblast differentiation "atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amer1tm1.1Nbar/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0009115 abnormal fat cell morphology "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
Show

Allelic Composition: Amer1tm1.1Nbar/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0009250 abnormal appendicular skeleton morphology "any structural anomaly of the bones of the limbs, shoulder and pelvic girdles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Amer1tm1.1Nbar/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amer1tm1.1Nbar/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Amer1tm1.1Nbar/Y,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

 MP:0009432 increased fetal weight "increase in the weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

Allelic Composition: Amer1tm1.2Nbar/Amer1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0010875 increased bone volume "increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Amer1tm1.1Nbar/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Amer1tm1.1Nbar/Y,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

 MP:0010984 abnormal metanephric mesenchyme morphology "any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, in the developing metanephros; interactions between the ureteric bud and the metanephric mesenchyme leads to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:19828308]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0011168 abnormal fat cell differentiation "abnormal or arrest of differentiation of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449, MGI:csmith]
Show

Allelic Composition: Amer1tm1.1Nbar/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0011386 increased metanephric mesenchyme apoptosis "increase in the number of cells of the metanephric mesenchyme (MM) undergoing programmed cell death; usually due to failure of MM cells to interact with the ureteric bud (UB) tips after UB invasion" [MGI:anna]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0020039 increased bone ossification "increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Amer1tm1.1Nbar/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Amer1tm1.1Nbar/Y,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

 MP:0020080 increased bone mineralization "increase in the rate at which minerals are deposited into bone" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Amer1tm1.1Nbar/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Amer1tm1.1Nbar/Y,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

 MP:0020138 delayed bone mineralization "late onset of the process by which minerals are deposited into bone" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Amer1tm1.1Nbar/Y,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0030316 enlarged neurocranium "increased size of the bones of the skull enclosing the brain" [MGI:anna]
Show

Allelic Composition: ax/a
Genetic Background: B6.Cg-ax

 MP:0030388 large fontanelles "an abnormally increased size of one or more fontanelles for age-related norms, generally resulting from delayed or incomplete fontanelle closure" [HP:0000239, MGI:anna]
Show

Allelic Composition: Amer1tm1.1Nbar/Y,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

 MP:0030393 delayed fontanelle closure "late onset of closure of one or more of the membranous intervals at the margins of cranial bones" [MGI:anna]
Show

Allelic Composition: Amer1tm1.1Nbar/Y,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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