ENSMUSG00000051234


Mus musculus

Features
Gene ID: ENSMUSG00000051234
  
Biological name :Rnf7
  
Synonyms : Q9WTZ1 / RING-box protein 2 / Rnf7
  
Possible biological names infered from orthology : Q9UBF6 / ring finger protein 7
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: E3.3
Gene start: 96470937
Gene end: 96478675
  
Corresponding Affymetrix probe sets: 10595803 (MoGene1.0st)   1426414_a_at (Mouse Genome 430 2.0 Array)   1456600_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000052856
Ensembl peptide - ENSMUSP00000108581
NCBI entrez gene - 19823     See in Manteia.
MGI - MGI:1337096
RefSeq - NM_001311135
RefSeq - NM_011279
RefSeq Peptide - NP_001298064
RefSeq Peptide - NP_035409
swissprot - Q9WTZ1
swissprot - D3Z392
Ensembl - ENSMUSG00000051234
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rnf7ENSDARG00000055524Danio rerio
 RNF7ENSGALG00000021117Gallus gallus
 RNF7ENSG00000114125Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm7075 / RNF7* / Q9UBF6* / ring finger protein 7*ENSMUSG0000004818596
Rbx1 / P62878 / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed / P62877* / ring-box 1*ENSMUSG0000002240044


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR024766  Zinc finger, RING-H2-type
 IPR024991  Anaphase-promoting complex subunit 11


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IDA
 biological_processGO:0008637 apoptotic mitochondrial changes IDA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0021799 cerebral cortex radially oriented cell migration IMP
 biological_processGO:0021942 radial glia guided migration of Purkinje cell IMP
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0045116 protein neddylation ISO
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005680 anaphase-promoting complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0031462 Cul2-RING ubiquitin ligase complex IBA
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex IBA
 cellular_componentGO:0031466 Cul5-RING ubiquitin ligase complex ISO
 cellular_componentGO:0031467 Cul7-RING ubiquitin ligase complex IBA
 cellular_componentGO:0043224 nuclear SCF ubiquitin ligase complex IBA
 cellular_componentGO:0080008 Cul4-RING E3 ubiquitin ligase complex IBA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0019788 NEDD8 transferase activity ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA
 molecular_functionGO:0097602 cullin family protein binding ISO


Pathways (from Reactome)
Pathway description
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Rnf7Gt(XE423)Byg/Rnf7Gt(XE423)Byg
Genetic Background: involves: 129 * C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Rnf7Gt(XE423)Byg/Rnf7Gt(XE423)Byg
Genetic Background: involves: 129 * C57BL/6

 MP:0000792 abnormal cortical marginal zone morphology 
Show

Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
Show

Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000884 delaminated Purkinje cell layer "splitting or disorganization of the layer of large neuron cell bodies between the molecular and granular layers of the cerebellum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61509]
Show

Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000885 ectopic Purkinje cell "Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, J:60896]
Show

Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
Show

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Krastm4Tyj/Kras+,Rnf7Gt(XE423)Byg/Rnf7+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
Show

Allelic Composition: Krastm4Tyj/Kras+,Rnf7Gt(XE423)Byg/Rnf7+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krastm4Tyj/Kras+,Rnf7Gt(XE423)Byg/Rnf7tm1.1Ysun
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Krastm4Tyj/Kras+,Rnf7Gt(XE423)Byg/Rnf7+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0003019 increased circulating chloride level "elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0003020 decreased circulating chloride level "reduced concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ap3b1pe-8J/Ap3b1pe-8J
Genetic Background: DBA/2J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Rnf7Gt(XE423)Byg/Rnf7Gt(XE423)Byg
Genetic Background: involves: 129 * C57BL/6

 MP:0004227 increased cellular sensitivity to ionizing radiation "increased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ap3b1pe-8J/Ap3b1pe-8J
Genetic Background: DBA/2J

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0005316 abnormal response to tactile stimuli "anomalous reflex action normally induced by touch or pain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1+
Genetic Background: Not Specified

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ap3b1pe-8J/Ap3b1pe-8J
Genetic Background: DBA/2J

Allelic Composition: Nf1tm1Par/Nf1tm1Par,Rnf7Gt(XE423)Byg/Rnf7Gt(XE423)Byg
Genetic Background: involves: 129 * C57BL/6

 MP:0008439 abnormal cortical plate morphology "any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
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Allelic Composition: Dab1tm1Cpr/Dab1tm1Cpr,Rnf7tm1c(EUCOMM)Wtsi/Rnf7tm1c(EUCOMM)Wtsi,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * SJL

 MP:0009956 abnormal cerebellar layer morphology "any structural anomaly of the laminar structure of the cerebellar cortex comprising the gray matter of the cerebellum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0010267 decreased lung tumor incidence "less than the expected number of neoplams in the lung, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krastm4Tyj/Kras+,Rnf7Gt(XE423)Byg/Rnf7tm1.1Ysun
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0011204 abnormal visceral yolk sac blood island morphology "any structural anomaly of the masses of developing blood cells attached to endothelium in the yolk sac" [PMID:16140152]
Show

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
Show

Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0013182 increased spinal cord apoptosis "increase in the number of cells of the neural tube undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Notch2*)Uzs/Gt(ROSA)26Sor+,Cd19tm1(cre)Cgn/Cd19tm1(cre)Cgn
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

 MP:0013551 decreased cerebellar granule cell precursor proliferation "reduction in the ability of a cerebellar granule cell precursor population to undergo rapid expansion by cell division" [MGI:csmith]
Show

Allelic Composition: Lyntm1.1Calo/Lyntm1.1Calo,Tg(Itgax-cre)1-1Reiz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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