ENSMUSG00000051980


Mus musculus

Features
Gene ID: ENSMUSG00000051980
  
Biological name :Casr
  
Synonyms : Casr / Extracellular calcium-sensing receptor / Q9QY96
  
Possible biological names infered from orthology : calcium sensing receptor / P41180
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B3
Gene start: 36493696
Gene end: 36562141
  
Corresponding Affymetrix probe sets: 10439303 (MoGene1.0st)   1449881_a_at (Mouse Genome 430 2.0 Array)   1449882_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000069080
Ensembl peptide - ENSMUSP00000110496
Ensembl peptide - ENSMUSP00000133500
NCBI entrez gene - 12374     See in Manteia.
MGI - MGI:1351351
RefSeq - XM_017316856
RefSeq - NM_013803
RefSeq - XM_006521731
RefSeq - XM_006521732
RefSeq - XM_006521729
RefSeq - XM_006521730
RefSeq Peptide - NP_038831
swissprot - Q9QY96
Ensembl - ENSMUSG00000051980
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 casrENSDARG00000013649Danio rerio
 CASRENSGALG00000038405Gallus gallus
 CASRENSG00000036828Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vmn2r1 / vomeronasal 2, receptor 1ENSMUSG0000002782433
Vmn2r7 / vomeronasal 2, receptor 7ENSMUSG0000006220031
Vmn2r2 / vomeronasal 2, receptor 2ENSMUSG0000004389730
Vmn2r5 / vomeronasal 2, receptor 5ENSMUSG0000006899930
Vmn2r3 / vomeronasal 2, receptor 3ENSMUSG0000009157230
Vmn2r6ENSMUSG0000009058129
Vmn2r7ENSMUSG0000011602829
Vmn2r4 / vomeronasal 2, receptor 4ENSMUSG0000009204929
Vmn2r57 / vomeronasal 2, receptor 57ENSMUSG0000006653725
Vmn2r63ENSMUSG0000009075125
Vmn2r53ENSMUSG0000009600225
Vmn2r62ENSMUSG0000009192625
Vmn2r54ENSMUSG0000009659325
Vmn2r56 / vomeronasal 2, receptor 56ENSMUSG0000009076225
Vmn2r101 / vomeronasal 2, receptor 101ENSMUSG0000009489224
Vmn2r24 / vomeronasal 2, receptor 24ENSMUSG0000007278024
Vmn2r112 / vomeronasal 2, receptor 112ENSMUSG0000009492124
Vmn2r93 / vomeronasal 2, receptor 93ENSMUSG0000007969824
Vmn2r100ENSMUSG0000009185924
Vmn2r36 / vomeronasal 2, receptor 36ENSMUSG0000009165124


Protein motifs (from Interpro)
Interpro ID Name
 IPR000337  GPCR, family 3
 IPR001828  Receptor, ligand binding region
 IPR011500  GPCR, family 3, nine cysteines domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017978  GPCR family 3, C-terminal
 IPR017979  GPCR, family 3, conserved site
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0002931 response to ischemia IEA
 biological_processGO:0005513 detection of calcium ion ISS
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis ISS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007254 JNK cascade IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010038 response to metal ion IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0032024 positive regulation of insulin secretion IEA
 biological_processGO:0032781 positive regulation of ATPase activity IMP
 biological_processGO:0035729 cellular response to hepatocyte growth factor stimulus IEA
 biological_processGO:0042311 vasodilation IEA
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IEA
 biological_processGO:0050927 positive regulation of positive chemotaxis IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0051924 regulation of calcium ion transport IDA
 biological_processGO:0060613 fat pad development IEA
 biological_processGO:0070509 calcium ion import ISO
 biological_processGO:0071305 cellular response to vitamin D IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071404 cellular response to low-density lipoprotein particle stimulus IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071774 response to fibroblast growth factor IEA
 biological_processGO:0090280 positive regulation of calcium ion import IEA
 biological_processGO:1901653 cellular response to peptide IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043679 axon terminus IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity ISO
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0016597 amino acid binding ISS
 molecular_functionGO:0019808 polyamine binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events
G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Camk2a-cre)93Kln/0
Genetic Background: involves: 129S4/SvJae * CBA/J

 MP:0000061 fragile skeleton "easily damaged or broken bones" [J:14208]
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Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(PTH-cre)4167Slib/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Camk2a-cre)93Kln/0
Genetic Background: involves: 129S4/SvJae * CBA/J

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(PTH-cre)4167Slib/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Casrtm1Wch/Casr+,Tg(PTH-cre)4167Slib/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0000069 kyphoscoliosis "kyphosis combined with scoliosis" [MGI:CML, J:66943]
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Camk2a-cre)93Kln/0
Genetic Background: involves: 129S4/SvJae * CBA/J

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Casrtm1Wch/Casr+,Tg(PTH-cre)4167Slib/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Camk2a-cre)93Kln/0
Genetic Background: involves: 129S4/SvJae * CBA/J

Allelic Composition: Casrtm1Ces/Casr+
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(PTH-cre)4167Slib/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Casrtm1Wch/Casr+,Tg(PTH-cre)4167Slib/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: CasrBCH002/CasrBCH002
Genetic Background: C3HeB/FeJ-CasrBCH002

Allelic Composition: CasrBCH003/CasrBCH003
Genetic Background: C3HeB/FeJ-CasrBCH003

Allelic Composition: CasrBCH004/CasrBCH004
Genetic Background: C3HeB/FeJ-CasrBCH004

Allelic Composition: CasrBCH007/CasrBCH007
Genetic Background: C3HeB/FeJ-CasrBCH007

Allelic Composition: CasrBCH011/CasrBCH011
Genetic Background: C3HeB/FeJ-CasrBCH011

Allelic Composition: CasrBCH013/CasrBCH013
Genetic Background: C3HeB/FeJ-CasrBCH013

 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kittm1Bpr/Kit+
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)

Allelic Composition: CasrNuf/Casr+
Genetic Background: either: (involves: 102/El * 102/H * C3H/He) or (involves: 102/El * C3H/He * C3H/HeH)

 MP:0000198 hypophosphatemia "abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Camk2a-cre)93Kln/0
Genetic Background: involves: 129S4/SvJae * CBA/J

Allelic Composition: CasrBCH002/CasrBCH002
Genetic Background: C3HeB/FeJ-CasrBCH002

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Camk2a-cre)93Kln/0
Genetic Background: involves: 129S4/SvJae * CBA/J

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(PTH-cre)4167Slib/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Camk2a-cre)93Kln/0
Genetic Background: involves: 129S4/SvJae * CBA/J

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: CasrBCH002/CasrBCH002
Genetic Background: C3HeB/FeJ-CasrBCH002

Allelic Composition: CasrBCH007/CasrBCH007
Genetic Background: C3HeB/FeJ-CasrBCH007

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Kittm1Bpr/Kit+
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)

Allelic Composition: CasrNuf/Casr+
Genetic Background: either: (involves: 102/El * 102/H * C3H/He) or (involves: 102/El * C3H/He * C3H/HeH)

 MP:0001429 dehydration "excessive water loss from the body or from an organ or bodily part" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:50053]
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Camk2a-cre)93Kln/0
Genetic Background: involves: 129S4/SvJae * CBA/J

 MP:0001438 aphagia "inability to eat " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404]
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Camk2a-cre)93Kln/0
Genetic Background: involves: 129S4/SvJae * CBA/J

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Camk2a-cre)93Kln/0
Genetic Background: involves: 129S4/SvJae * CBA/J

 MP:0001566 hyperphosphatemia "abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kittm1Bpr/Kit+
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)

Allelic Composition: CasrNuf/Casr+
Genetic Background: either: (involves: 102/El * 102/H * C3H/He) or (involves: 102/El * C3H/He * C3H/HeH)

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Camk2a-cre)93Kln/0
Genetic Background: involves: 129S4/SvJae * CBA/J

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(PTH-cre)4167Slib/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trim32tm1Hdin/Trim32tm1Hdin
Genetic Background: involves: 129S1/Sv

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kittm1Bpr/Kit+
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grhl3tm1Jane/Grhl3+,Ptentm1Mak/Pten+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Camk2a-cre)93Kln/0
Genetic Background: involves: 129S4/SvJae * CBA/J

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Camk2a-cre)93Kln/0
Genetic Background: involves: 129S4/SvJae * CBA/J

 MP:0002902 hypophosphaturia "a reduction of excretion of phosphates in the urine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kittm1Bpr/Kit+
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)

 MP:0002904 increased circulating parathyroid hormone level "greater than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Camk2a-cre)93Kln/0
Genetic Background: involves: 129S4/SvJae * CBA/J

Allelic Composition: Casrtm1Ces/Casr+
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(PTH-cre)4167Slib/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Casrtm1Wch/Casr+,Tg(PTH-cre)4167Slib/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0002905 decreased circulating parathyroid hormone level "less than expected blood concentration of this regulator of calcium and phosphorous concentration" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Kittm1Bpr/Kit+
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)

Allelic Composition: CasrNuf/Casr+
Genetic Background: either: (involves: 102/El * 102/H * C3H/He) or (involves: 102/El * C3H/He * C3H/HeH)

 MP:0002980 abnormal postural reflex "failure to respond with the normal extension of legs to maintain balance when the cage is tilted" [smb:Susan M. Bello , Mouse Genome Informatics Curator, J:88306]
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Camk2a-cre)93Kln/0
Genetic Background: involves: 129S4/SvJae * CBA/J

 MP:0002986 hypocalciuria "excretion of abnormally low amounts of calcium in the urine" [J:83000]
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Camk2a-cre)93Kln/0
Genetic Background: involves: 129S4/SvJae * CBA/J

Allelic Composition: Casrtm1Ces/Casr+
Genetic Background: involves: 129X1/SvJ * Black Swiss

Allelic Composition: CasrNuf/CasrNuf
Genetic Background: involves: 102/El * C3H/He

 MP:0003112 enlarged parathyroid gland 
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Camk2a-cre)93Kln/0
Genetic Background: involves: 129S4/SvJae * CBA/J

 MP:0003114 pigmented parathyroid gland 
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Camk2a-cre)93Kln/0
Genetic Background: involves: 129S4/SvJae * CBA/J

 MP:0003116 rickets "overproduction and deficient calcification of osteoid tissue due to vitamin D deficiency; can lead to skeletal deformities, growth defects, hypocalcemia, and sometimes tetany; skeletal fractures occur frequently" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Camk2a-cre)93Kln/0
Genetic Background: involves: 129S4/SvJae * CBA/J

 MP:0003195 calcinosis "pathologic deposition of calcium salts in tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: CasrNuf/CasrNuf
Genetic Background: involves: 102/El * C3H/He

 MP:0003197 kidney calcification "pathologic deposition of calcium salts in the kidney" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: CasrNuf/CasrNuf
Genetic Background: involves: 102/El * C3H/He

 MP:0003199 muscle calcification "pathologic deposition of calcium salts in muscle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: CasrNuf/CasrNuf
Genetic Background: involves: 102/El * C3H/He

 MP:0003408 increased width of hypertrophic chondrocyte zone "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Camk2a-cre)93Kln/0
Genetic Background: involves: 129S4/SvJae * CBA/J

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0003493 parathyroid hyperplasia 
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Camk2a-cre)93Kln/0
Genetic Background: involves: 129S4/SvJae * CBA/J

 MP:0004842 abnormal large intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Camk2a-cre)93Kln/0
Genetic Background: involves: 129S4/SvJae * CBA/J

 MP:0005441 hypercalciuria "excretion of abnormally large amounts of calcium in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86949]
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Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(PTH-cre)4167Slib/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Casrtm1Wch/Casr+,Tg(PTH-cre)4167Slib/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(PTH-cre)4167Slib/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Casrtm1Wch/Casr+,Tg(PTH-cre)4167Slib/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0010092 increased circulating magnesium level "an elevation in the blood concentration of magnesium" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Camk2a-cre)93Kln/0
Genetic Background: involves: 129S4/SvJae * CBA/J

Allelic Composition: Casrtm1Ces/Casr+
Genetic Background: involves: 129X1/SvJ * Black Swiss

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(PTH-cre)4167Slib/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casrtm1Wch/Casr+,Tg(PTH-cre)4167Slib/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0010933 decreased trabecular bone connectivity density "reduction in the extent of attachments between trabeculae; it may be expressed in ratios of nodes to free ends, trabecular bone pattern factor, and related measures" [ISBN:0120986523 "Principles of bone biology, Volume 1, Bilezikian, JP et al, eds"]
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Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0010965 decreased compact bone volume 
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Allelic Composition: Casrtm1Wch/Casr+,Tg(PTH-cre)4167Slib/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Camk2a-cre)93Kln/0
Genetic Background: involves: 129S4/SvJae * CBA/J

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(PTH-cre)4167Slib/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0013572 abnormal parathyroid gland chief cell morphology "any structural anomaly of an epithelial cell that are collectively arranged in wide, irregular interconnecting columns in the parathyroid gland, that is responsible for the synthesis and secretion of parathyroid hormone (PTH)" [CL:0000446, MGI:Anna]
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Camk2a-cre)93Kln/0
Genetic Background: involves: 129S4/SvJae * CBA/J

 MP:0020137 decreased bone mineralization "decrease in the rate at which minerals are deposited into bone" []
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Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(PTH-cre)4167Slib/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col1a1-cre)2Bek/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col2a1-cre)1Bhr/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Casrtm1Wch/Casrtm1Wch,Tg(Col2a1-cre/ERT)KA3Smac/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0030129 tongue inflammation "local accumulation of fluid, plasma proteins and leukocytes in the tongue" [MGI:anna]
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Allelic Composition: CasrNuf/CasrNuf
Genetic Background: involves: 102/El * C3H/He

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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