ENSMUSG00000052557


Mus musculus

Features
Gene ID: ENSMUSG00000052557
  
Biological name :Gan
  
Synonyms : Gan / Gigaxonin / Q8CA72
  
Possible biological names infered from orthology : Q9H2C0
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E1
Gene start: 117158135
Gene end: 117215997
  
Corresponding Affymetrix probe sets: 10575763 (MoGene1.0st)   1434845_at (Mouse Genome 430 2.0 Array)   1439615_at (Mouse Genome 430 2.0 Array)   1458444_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000070168
Ensembl peptide - ENSMUSP00000124904
NCBI entrez gene - 209239     See in Manteia.
MGI - MGI:1890619
RefSeq - NM_001081151
RefSeq Peptide - NP_001074620
swissprot - F6TZU3
swissprot - Q8CA72
Ensembl - ENSMUSG00000052557
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GANENSDARG00000100875Danio rerio
 GANENSGALG00000013437Gallus gallus
 GANENSG00000261609Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Klhl13 / Q80TF4 / Kelch-like protein 13 / Q9P2N7* / kelch like family member 13*ENSMUSG0000003678224
Klhl9 / Q6ZPT1 / Kelch-like protein 9 / Q9P2J3* / kelch like family member 9*ENSMUSG0000007092324
Klhl31 / kelch like family member 31 / Q9H511*ENSMUSG0000004493823
Klhl36 / Q8R124 / Kelch-like protein 36 / Q8N4N3* / kelch like family member 36*ENSMUSG0000003182823
Ipp / P28575 / Actin-binding protein IPP / Q9Y573* / intracisternal A particle-promoted polypeptide*ENSMUSG0000002869623
Klhl14 / Q69ZK5 / Kelch-like protein 14 / Q9P2G3* / kelch like family member 14*ENSMUSG0000004251423
Klhl32 / kelch like family member 32 / Q96NJ5*ENSMUSG0000004038722
A2AAX3 / Klhl15 / Kelch-like protein 15 / Q96M94* / kelch like family member 15*ENSMUSG0000004392921
Klhl26 / Q8BGY4 / Kelch-like protein 26 / Q53HC5* / kelch like family member 26*ENSMUSG0000005570721
Klhl34 / kelch like family member 34 / Q8N239*ENSMUSG0000004748521
Klhl22 / Q99JN2 / Mus musculus kelch-like 22 (Klhl22), transcript variant 2, mRNA. / Q53GT1* / kelch like family member 22*ENSMUSG0000002275020
Klhl7 / Q8BUL5 / kelch-like 7 / Q8IXQ5* / kelch like family member 7*ENSMUSG0000002898620
Q920Q8 / Ivns1abp / Influenza virus NS1A-binding protein homolog / Q9Y6Y0* / influenza virus NS1A binding protein*ENSMUSG0000002315020
Klhl33 / kelch like family member 33 / A6NCF5*ENSMUSG0000009079920


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR006652  Kelch repeat type 1
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR011705  BTB/Kelch-associated
 IPR015915  Kelch-type beta propeller
 IPR017096  BTB-kelch protein
 IPR030579  Gigaxonin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization ISO
 biological_processGO:0016567 protein ubiquitination ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Catf/Catf
Genetic Background: Not Specified

 MP:0000743 muscle spasms "muscular twitching, cramps and seizures ; frequently associated with calcium deficiency, hypoparathyroidism, vitamin D deficiency or alkalosis " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Catf/Catf
Genetic Background: Not Specified

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
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Allelic Composition: Catf/Catf
Genetic Background: Not Specified

 MP:0000748 progressive muscle weakness "increasing loss of strength over time" [MGI:CLS, J:67994]
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Allelic Composition: Catf/Catf
Genetic Background: Not Specified

 MP:0000940 abnormal motor neuron innervation "misprojection or failure to bundle motor axons to an effector tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Gantm1Jpj/Gantm1Jpj
Genetic Background: involves: C57BL/6

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Catf/Catf
Genetic Background: Not Specified

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Catf/Catf
Genetic Background: Not Specified

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Catf/Catf
Genetic Background: Not Specified

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Catf/Catf
Genetic Background: Not Specified

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Catf/Catf
Genetic Background: Not Specified

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Catf/Catf
Genetic Background: Not Specified

Allelic Composition: Gantm1Jpj/Gantm1Jpj
Genetic Background: involves: C57BL/6

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Catf/Catf
Genetic Background: Not Specified

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Gantm1Jpj/Gantm1Jpj
Genetic Background: involves: C57BL/6

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Catf/Catf
Genetic Background: Not Specified

 MP:0003993 abnormal ventral spinal root morphology "any anomaly, deformity, or malformation of the anterior bundle of nerves emerging from the spinal cord to join with the posterior/dorsal nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Gantm1Jpj/Gantm1Jpj
Genetic Background: involves: C57BL/6

 MP:0004768 abnormal axonal transport "any functional anomaly of the directed movement of organelles or vesicles along microtubules in nerve cell axons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Catf/Catf
Genetic Background: Not Specified

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Catf/Catf
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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