ENSMUSG00000052812


Mus musculus

Features
Gene ID: ENSMUSG00000052812
  
Biological name :Atad2b
  
Synonyms : Atad2b / ATPase family, AAA domain containing 2B
  
Possible biological names infered from orthology : Q9ULI0
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A1.1
Gene start: 4917353
Gene end: 5047394
  
Corresponding Affymetrix probe sets: 10394366 (MoGene1.0st)   10394381 (MoGene1.0st)   1428982_at (Mouse Genome 430 2.0 Array)   1446719_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151695
Ensembl peptide - ENSMUSP00000047445
NCBI entrez gene - 320817     See in Manteia.
MGI - MGI:2444798
RefSeq - XM_017315116
RefSeq - XM_006515115
RefSeq - XM_006515116
RefSeq - XM_006515117
RefSeq - NM_001099628
RefSeq Peptide - NP_001093098
swissprot - E9Q166
swissprot - A0A1W2P7J4
Ensembl - ENSMUSG00000052812
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atad2bENSDARG00000060537Danio rerio
 ATAD2BENSGALG00000037872Gallus gallus
 ATAD2BENSG00000119778Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atad2 / Q8CDM1 / ATPase family AAA domain-containing protein 2 / Q6PL18* / ATPase family, AAA domain containing 2*ENSMUSG0000002236045


Protein motifs (from Interpro)
Interpro ID Name
 IPR001487  Bromodomain
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR003960  ATPase, AAA-type, conserved site
 IPR018359  Bromodomain, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036427  Bromodomain-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0031936 negative regulation of chromatin silencing IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016887 ATPase activity IBA
 molecular_functionGO:0042393 histone binding IBA
 molecular_functionGO:0070577 lysine-acetylated histone binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Lmx1atm1Ics/Lmx1atm1Ics,Lmx1btm1Rjo/Lmx1b+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Lmx1atm1Ics/Lmx1atm1Ics,Lmx1btm1Rjo/Lmx1b+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ascc2tm1b(EUCOMM)Wtsi/Ascc2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ascc2tm1b(EUCOMM)Wtsi/Bay

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ascc2tm1b(EUCOMM)Wtsi/Ascc2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ascc2tm1b(EUCOMM)Wtsi/Bay

 MP:0004357 long tibia "increased length of the medial and larger of the two bones of the lower leg" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ascc2tm1b(EUCOMM)Wtsi/Ascc2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ascc2tm1b(EUCOMM)Wtsi/Bay

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ascc2tm1b(EUCOMM)Wtsi/Ascc2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ascc2tm1b(EUCOMM)Wtsi/Bay

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ascc2tm1b(EUCOMM)Wtsi/Ascc2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ascc2tm1b(EUCOMM)Wtsi/Bay

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ascc2tm1b(EUCOMM)Wtsi/Ascc2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ascc2tm1b(EUCOMM)Wtsi/Bay

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Ascc2tm1b(EUCOMM)Wtsi/Ascc2tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ascc2tm1b(EUCOMM)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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