ENSMUSG00000053153


Mus musculus

Features
Gene ID: ENSMUSG00000053153
  
Biological name :Spag16
  
Synonyms : Q8K450 / Spag16 / Sperm-associated antigen 16 protein
  
Possible biological names infered from orthology : Q8N0X2 / sperm associated antigen 16
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C3
Gene start: 69826970
Gene end: 70725132
  
Corresponding Affymetrix probe sets: 10347163 (MoGene1.0st)   1429838_at (Mouse Genome 430 2.0 Array)   1431732_at (Mouse Genome 430 2.0 Array)   1431958_at (Mouse Genome 430 2.0 Array)   1441708_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000069821
Ensembl peptide - ENSMUSP00000109573
NCBI entrez gene - 66722     See in Manteia.
MGI - MGI:1913972
RefSeq - XM_006496194
RefSeq - NM_001271533
RefSeq - NM_029160
RefSeq Peptide - NP_083436
RefSeq Peptide - NP_001258462
swissprot - Q8K450
Ensembl - ENSMUSG00000053153
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SPAG16ENSGALG00000003148Gallus gallus
 Q8N0X2ENSG00000144451Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prpf4 / Q9DAW6 / pre-mRNA processing factor 4 / O43172*ENSMUSG0000006614816
Prpf19 / Q99KP6 / Pre-mRNA-processing factor 19 / Q9UMS4*ENSMUSG0000002473513


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007288 sperm axoneme assembly IMP
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0035082 axoneme assembly ISO
 biological_processGO:0051012 microtubule sliding IMP
 biological_processGO:0060271 cilium assembly IDA
 biological_processGO:0060294 cilium movement involved in cell motility IMP
 biological_processGO:0097231 cell motility in response to calcium ion IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0005930 axoneme IDA
 cellular_componentGO:0031514 motile cilium IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:1990716 axonemal central apparatus IMP
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

Allelic Composition: Spag16tm2Jfs/Spag16tm2Jfs
Genetic Background: involves: 129S6/SvEvTac

 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

Allelic Composition: Spag16tm2Jfs/Spag16+
Genetic Background: involves: 129S6/SvEvTac

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

Allelic Composition: Spag16tm2Jfs/Spag16tm2Jfs
Genetic Background: involves: 129S6/SvEvTac

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

 MP:0002674 abnormal sperm motility "anomalies in the mobility of the spermatozoa" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spag16tm2Jfs/Spag16tm2Jfs
Genetic Background: involves: 129S6/SvEvTac

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spag16tm2Jfs/Spag16tm2Jfs
Genetic Background: involves: 129S6/SvEvTac

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

 MP:0009237 kinked sperm flagellum "a sharp bend or zigzag in the sperm tail" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

 MP:0009838 abnormal sperm axoneme morphology "any structural abnormality of the central core of the sperm flagellum, composed of a ring of 9 outer microtubule doublets surrounding a central pair; inner and outer dynein arms project from each of the outer 9 doublets, and these arms are responsible for generating the motive force of the flagellum; in addition, 9 radial spokes, each of which originates from 1 of the 9 outer microtubular doublet pairs, project inward toward the central pair in a helical fashion" [PMID:14581499]
Show

Allelic Composition: Large1myd/Large1+
Genetic Background: B6C3Fe a/a-Large1myd/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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