ENSMUSG00000024735


Mus musculus

Features
Gene ID: ENSMUSG00000024735
  
Biological name :Prpf19
  
Synonyms : Pre-mRNA-processing factor 19 / Prpf19 / Q99KP6
  
Possible biological names infered from orthology : Q9UMS4
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 10895231
Gene end: 10909559
  
Corresponding Affymetrix probe sets: 10461568 (MoGene1.0st)   1419839_x_at (Mouse Genome 430 2.0 Array)   1444939_at (Mouse Genome 430 2.0 Array)   1449635_at (Mouse Genome 430 2.0 Array)   1456531_x_at (Mouse Genome 430 2.0 Array)   1460633_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025642
Ensembl peptide - ENSMUSP00000136858
NCBI entrez gene - 28000     See in Manteia.
MGI - MGI:106247
RefSeq - NM_001253844
RefSeq - NM_001253843
RefSeq - NM_134129
RefSeq Peptide - NP_001240772
RefSeq Peptide - NP_001240773
RefSeq Peptide - NP_598890
swissprot - Q99KP6
Ensembl - ENSMUSG00000024735
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prpf19ENSDARG00000015239Danio rerio
 ENSGALG00000036530Gallus gallus
 PRPF19ENSG00000110107Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prpf4 / Q9DAW6 / pre-mRNA processing factor 4 / O43172*ENSMUSG0000006614819
Q8K450 / Spag16 / Sperm-associated antigen 16 protein / Q8N0X2* / sperm associated antigen 16*ENSMUSG0000005315316


Protein motifs (from Interpro)
Interpro ID Name
 IPR000772  Ricin B, lectin domain
 IPR001680  WD40 repeat
 IPR003613  U box domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013915  Pre-mRNA-splicing factor 19
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0000244 spliceosomal tri-snRNP complex assembly IEA
 biological_processGO:0000245 spliceosomal complex assembly IEA
 biological_processGO:0000349 generation of catalytic spliceosome for first transesterification step IBA
 biological_processGO:0000398 mRNA splicing, via spliceosome IEA
 biological_processGO:0001833 inner cell mass cell proliferation IMP
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0008610 lipid biosynthetic process IDA
 biological_processGO:0010498 proteasomal protein catabolic process IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0034613 cellular protein localization IEA
 biological_processGO:0045665 negative regulation of neuron differentiation IDA
 biological_processGO:0045666 positive regulation of neuron differentiation ISO
 biological_processGO:0048026 positive regulation of mRNA splicing, via spliceosome IMP
 biological_processGO:0048711 positive regulation of astrocyte differentiation IEA
 biological_processGO:0070534 protein K63-linked ubiquitination IEA
 biological_processGO:0072422 signal transduction involved in DNA damage checkpoint IEA
 cellular_componentGO:0000974 Prp19 complex IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005662 DNA replication factor A complex IEA
 cellular_componentGO:0005681 spliceosomal complex ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005811 lipid droplet IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0035861 site of double-strand break IEA
 cellular_componentGO:0071013 catalytic step 2 spliceosome ISO
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0034450 ubiquitin-ubiquitin ligase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
Formation of TC-NER Pre-Incision Complex
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
mRNA Splicing - Major Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kat2atm2Roth/Kat2atm2Roth
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kat2atm2Roth/Kat2atm2Roth
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0010380 inner cell mass apoptosis "the cells of the blastocyst that develop into the body of the embryo are undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kat2atm2Roth/Kat2atm2Roth
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Kat2atm2Roth/Kat2atm2Roth
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0012114 absent inner cell mass proliferation 
Show

Allelic Composition: Kat2atm2Roth/Kat2atm2Roth
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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