ENSMUSG00000053226


Mus musculus

Features
Gene ID: ENSMUSG00000053226
  
Biological name :Dand5
  
Synonyms : Dand5 / DAN domain family member 5 / Q76LW6
  
Possible biological names infered from orthology : DAN domain BMP antagonist family member 5 / Q8N907
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: C2
Gene start: 84815405
Gene end: 84822823
  
Corresponding Affymetrix probe sets: 10580202 (MoGene1.0st)   1436476_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000070057
NCBI entrez gene - 23863     See in Manteia.
MGI - MGI:1344365
RefSeq - NM_201227
RefSeq Peptide - NP_957679
swissprot - Q76LW6
Ensembl - ENSMUSG00000053226
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dand5ENSDARG00000036471Danio rerio
 DAND5ENSG00000179284Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cer1 / O55233 / Cerberus / O95813* / cerberus 1, DAN family BMP antagonist*ENSMUSG0000003819225


Protein motifs (from Interpro)
Interpro ID Name
 IPR004133  DAN
 IPR006207  Cystine knot, C-terminal
 IPR016860  Cerberus
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003140 determination of left/right asymmetry in lateral mesoderm IMP
 biological_processGO:0003281 ventricular septum development IMP
 biological_processGO:0003283 atrial septum development IMP
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0017015 regulation of transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0023019 signal transduction involved in regulation of gene expression IBA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IGI
 biological_processGO:0030514 negative regulation of BMP signaling pathway IDA
 biological_processGO:0035582 sequestering of BMP in extracellular matrix IBA
 biological_processGO:0038101 sequestering of nodal from receptor via nodal binding IDA
 biological_processGO:0061371 determination of heart left/right asymmetry IMP
 biological_processGO:1900108 negative regulation of nodal signaling pathway IDA
 biological_processGO:1900146 negative regulation of nodal signaling pathway involved in determination of left/right asymmetry ISS
 biological_processGO:1900164 nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry NAS
 biological_processGO:1900176 negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry IBA
 cellular_componentGO:0005576 extracellular region NAS
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016015 morphogen activity IMP


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001706 abnormal left-right axis patterning "anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Etv6tm2Sho/Etv6tm2Sho,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Etv6tm2Sho/Etv6tm2Sho,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0002766 situs inversus "lateral transposition of the viscera of the thorax and abdomen, sometimes incomplete" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Etv6tm2Sho/Etv6tm2Sho,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0003178 left pulmonary isomerism "bilaterally symmetric left lung pattern (or altered asymmetric patterning of the lung)" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93051]
Show

Allelic Composition: Etv6tm2Sho/Etv6tm2Sho,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0004252 abnormal direction of looping morphogenesis "deviation from the normal rightward direction of cardiac looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Etv6tm2Sho/Etv6tm2Sho,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

Allelic Composition: Dand5tm1Belo/Dand5tm1Belo,Nodaltm1.1Mku/Nodal+
Genetic Background: involves: 129/Ola * C57BL/6J

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Etv6tm2Sho/Etv6tm2Sho,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
Show

Allelic Composition: Etv6tm2Sho/Etv6tm2Sho,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Etv6tm2Sho/Etv6tm2Sho,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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