ENSMUSG00000038192


Mus musculus

Features
Gene ID: ENSMUSG00000038192
  
Biological name :Cer1
  
Synonyms : Cer1 / Cerberus / O55233
  
Possible biological names infered from orthology : cerberus 1, DAN family BMP antagonist / O95813
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C3
Gene start: 82881751
Gene end: 82885148
  
Corresponding Affymetrix probe sets: 10514083 (MoGene1.0st)   1450256_at (Mouse Genome 430 2.0 Array)   1450257_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048607
NCBI entrez gene - 12622     See in Manteia.
MGI - MGI:1201414
RefSeq - NM_009887
RefSeq Peptide - NP_034017
swissprot - A2ADM9
swissprot - O55233
Ensembl - ENSMUSG00000038192
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dand5ENSDARG00000036471Danio rerio
 CER1ENSGALG00000005434Gallus gallus
 CER1ENSG00000147869Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dand5 / Q76LW6 / DAN domain family member 5 / Q8N907* / DAN domain BMP antagonist family member 5*ENSMUSG0000005322617


Protein motifs (from Interpro)
Interpro ID Name
 IPR004133  DAN
 IPR006207  Cystine knot, C-terminal
 IPR016860  Cerberus
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001657 ureteric bud development IMP
 biological_processGO:0003419 growth plate cartilage chondrocyte proliferation IEP
 biological_processGO:0007369 gastrulation IGI
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IGI
 biological_processGO:0009948 anterior/posterior axis specification IGI
 biological_processGO:0009952 anterior/posterior pattern specification IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0023019 signal transduction involved in regulation of gene expression IDA
 biological_processGO:0030282 bone mineralization ISO
 biological_processGO:0030514 negative regulation of BMP signaling pathway IDA
 biological_processGO:0032926 negative regulation of activin receptor signaling pathway IDA
 biological_processGO:0035582 sequestering of BMP in extracellular matrix IDA
 biological_processGO:0042074 cell migration involved in gastrulation IGI
 biological_processGO:0048263 determination of dorsal identity ISO
 biological_processGO:0061371 determination of heart left/right asymmetry IBA
 biological_processGO:0071773 cellular response to BMP stimulus ISS
 biological_processGO:1900176 negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry IBA
 biological_processGO:2000381 negative regulation of mesoderm development IDA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0016015 morphogen activity ISO
 molecular_functionGO:0036122 BMP binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
Signaling by BMP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000077 abnormal interparietal bone morphology "malformed bone of the cranium; lies above and anterior to the occipital bone " [J:61509]
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Allelic Composition: Cer1tm1Belo/Cer1tm1Belo,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000107 abnormal frontal bone morphology "malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Cer1tm1Belo/Cer1tm1Belo,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000109 abnormal parietal bone morphology "malformed curved bone forming part of the vault of the cranium" [J:17489]
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Allelic Composition: Cer1tm1Belo/Cer1tm1Belo,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Cer1tm1Belo/Cer1tm1Belo,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Cer1tm1Belo/Cer1tm1Belo,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Cer1tm1Belo/Cer1tm1Belo,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Thratm1Ven/Thratm1Ven
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Thratm1Ven/Thratm1Ven
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Thratm1Ven/Thratm1Ven
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Sla/Lefty1tm1Sla,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * CD-1

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * CD-1

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nrg1tm1Cbm/Nrg1tm3Cbm,Isl2tm1Arbr/Isl2+
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Sla/Lefty1tm1Sla,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * CD-1

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * CD-1

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Sla/Lefty1tm1Sla,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * CD-1

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * CD-1

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Csf2rbtm1Cgb/Csf2rbtm1Cgb
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cer1tm1Belo/Cer1tm1Belo
Genetic Background: either: 129X1/SvJ-Cer1tm1Belo or (involves: 129X1/SvJ * C57BL/6)

Allelic Composition: Cer1tm1Belo/Cer1tm1Belo
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lhx1tm1Bhr/Lhx1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002230 abnormal primitive streak formation "anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf10tm1Ska/Fgf10+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * CD-1

 MP:0002231 abnormal primitive streak morphology "anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf10tm1Ska/Fgf10+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * CD-1

 MP:0003063 increased coping response "enhanced ability to respond productively to a stressful situation" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Thratm1Ven/Thratm1Ven
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0003456 absent tail "completely lacking the appendage at the caudal end of the vertebral column " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cer1tm1Belo/Cer1tm1Belo,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Cer1tm1Belo/Cer1tm1Belo,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003886 abnormal embryonic epiblast morphology "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Fgf10tm1Ska/Fgf10+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * CD-1

 MP:0003890 abnormal embryonic-extraembryonic boundary morphology "anomaly in the normal development /maintenance of the connection between the embryo proper and extraembryonic tissues" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Sla/Lefty1tm1Sla,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * CD-1

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd,Nodaltm1Rob/Nodal+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S7/SvEvBrd * CD-1

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cer1tm1Belo/Cer1tm1Belo,Tdgf1tm1Eda/Tdgf1tm1Eda
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005269 abnormal occipital bone morphology "anomalous structure of the bone at the lower, posterior part of the skull" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cer1tm1Belo/Cer1tm1Belo,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006386 absent somites "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf10tm1Ska/Fgf10+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * CD-1

 MP:0008029 abnormal paraxial mesoderm "failure or abnormality in the formation of the mesoderm lying at either side of the midline embryonic notochord; on segmentation, paraxial mesoderm forms the paired somites" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf10tm1Ska/Fgf10+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * CD-1

 MP:0010029 abnormal basicranium morphology "any structural anomaly of the sloping floor of the cranial cavity that is comprised of parts of the ethmoidal, occipital and sphenoid bones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cer1tm1Belo/Cer1tm1Belo,Nogtm1Amc/Nogtm1Amc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010117 abnormal lateral plate mesoderm "anomaly of the portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Fgf10tm1Ska/Fgf10+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * CD-1

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Sla/Lefty1tm1Sla
Genetic Background: involves: 129S7/SvEvBrd * CD-1

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * CD-1

 MP:0011199 abnormal amniotic cavity morphology "any structural anomaly of the closed space between the embryo and the amnion, containing the amniotic fluid; it is formed by the fusion of the parts of the anterior and posterior amniotic folds" [ISBN:0-12-402035-6]
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Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * CD-1

 MP:0012135 embryonic-extraembryonic boundary constriction "an invagination or pinching in the visceral endoderm that is centered at the boundary between embryonic and extra-embryonic regions of the developing embryo, often resulting in physical separation of embryonic and extraembryonic ectoderm" [MGI:csmith]
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Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Sla/Lefty1tm1Sla
Genetic Background: involves: 129S7/SvEvBrd * CD-1

Allelic Composition: Cer1tm1Bhr/Cer1tm1Bhr,Lefty1tm1Hmd/Lefty1tm1Hmd
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038192 Cer1 / O55233 / Cerberus / O95813* / cerberus 1, DAN family BMP antagonist*  / complex






 

1 s.

 
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