ENSG00000147869


Homo sapiens

Features
Gene ID: ENSG00000147869
  
Biological name :CER1
  
Synonyms : CER1 / cerberus 1, DAN family BMP antagonist / O95813
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: p22.3
Gene start: 14719724
Gene end: 14722717
  
Corresponding Affymetrix probe sets: 221378_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000370297
NCBI entrez gene - 9350     See in Manteia.
OMIM - 603777
RefSeq - NM_005454
RefSeq Peptide - NP_005445
swissprot - O95813
Ensembl - ENSG00000147869
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dand5ENSDARG00000036471Danio rerio
 CER1ENSGALG00000005434Gallus gallus
 Cer1ENSMUSG00000038192Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DAND5 / Q8N907 / DAN domain BMP antagonist family member 5ENSG0000017928421


Protein motifs (from Interpro)
Interpro ID Name
 IPR004133  DAN
 IPR006207  Cystine knot, C-terminal
 IPR016860  Cerberus
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001657 ureteric bud development IEA
 biological_processGO:0003419 growth plate cartilage chondrocyte proliferation ISS
 biological_processGO:0007369 gastrulation ISS
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009948 anterior/posterior axis specification ISS
 biological_processGO:0009952 anterior/posterior pattern specification ISS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0023019 signal transduction involved in regulation of gene expression ISS
 biological_processGO:0030282 bone mineralization IMP
 biological_processGO:0030509 BMP signaling pathway TAS
 biological_processGO:0030514 negative regulation of BMP signaling pathway IEA
 biological_processGO:0032926 negative regulation of activin receptor signaling pathway IEA
 biological_processGO:0035582 sequestering of BMP in extracellular matrix IEA
 biological_processGO:0042074 cell migration involved in gastrulation ISS
 biological_processGO:0048263 determination of dorsal identity IMP
 biological_processGO:0061371 determination of heart left/right asymmetry IBA
 biological_processGO:0071773 cellular response to BMP stimulus IEA
 biological_processGO:1900176 negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry IBA
 biological_processGO:2000381 negative regulation of mesoderm development IEA
 cellular_componentGO:0005576 extracellular region ISS
 cellular_componentGO:0005615 extracellular space ISS
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0016015 morphogen activity IDA
 molecular_functionGO:0036122 BMP binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Signaling by NODAL
Regulation of signaling by NODAL
Signaling by BMP


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000156574 NODAL / Q96S42 / nodal growth differentiation factor  / reaction / complex
 ENSG00000147869 CER1 / O95813 / cerberus 1, DAN family BMP antagonist  / complex






 

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