ENSMUSG00000053414


Mus musculus

Features
Gene ID: ENSMUSG00000053414
  
Biological name :Hunk
  
Synonyms : Hormonally up-regulated neu tumor-associated kinase / Hunk / O88866
  
Possible biological names infered from orthology : hormonally up-regulated Neu-associated kinase / P57058
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: C3.3
Gene start: 90386397
Gene end: 90499553
  
Corresponding Affymetrix probe sets: 10436788 (MoGene1.0st)   1418260_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000068007
NCBI entrez gene - 26559     See in Manteia.
MGI - MGI:1347352
RefSeq - NM_015755
RefSeq - XM_011246130
RefSeq Peptide - NP_056570
swissprot - O88866
Ensembl - ENSMUSG00000053414
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hunkENSDARG00000091317Danio rerio
 HUNKENSGALG00000015879Gallus gallus
 HUNKENSG00000142149Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Melk / Q61846 / Maternal embryonic leucine zipper kinase / Q14680*ENSMUSG0000003568322


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR034671  Hormonally up-regulated neu tumour-associated kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001273 decreased metastatic potential 
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Hunktm1Lach/Hunk+,Tg(MMTV-Myc)#Led/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ercc6tm1Gvh/Ercc6tm1Gvh,Xpatm1Tnka/Xpatm1Tnka
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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