ENSMUSG00000035683


Mus musculus

Features
Gene ID: ENSMUSG00000035683
  
Biological name :Melk
  
Synonyms : Maternal embryonic leucine zipper kinase / Melk / Q61846
  
Possible biological names infered from orthology : Q14680
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: B1
Gene start: 44300876
Gene end: 44364675
  
Corresponding Affymetrix probe sets: 10504470 (MoGene1.0st)   1416558_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043806
Ensembl peptide - ENSMUSP00000120242
Ensembl peptide - ENSMUSP00000118359
NCBI entrez gene - 17279     See in Manteia.
MGI - MGI:106924
RefSeq - NM_010790
RefSeq - XM_006537640
RefSeq Peptide - NP_034920
swissprot - A2ALR0
swissprot - Q61846
swissprot - A2ALQ9
Ensembl - ENSMUSG00000035683
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 melkENSDARG00000030759Danio rerio
 MELKENSGALG00000016438Gallus gallus
 MELKENSG00000165304Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hunk / O88866 / Hormonally up-regulated neu tumor-associated kinase / P57058* / hormonally up-regulated Neu-associated kinase*ENSMUSG0000005341424


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001772  Kinase associated domain 1 (KA1)
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR028375  KA1 domain/Ssp2, C-terminal
 IPR034673  Maternal embryonic leucine zipper kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030097 hemopoiesis ISS
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0061351 neural precursor cell proliferation IDA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISS
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity ISO
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005518 abnormal pancreas regeneration "deviation from the normal ability of the pancreas to regenerate healthy tissue following injury" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Lrrk2tm1.1Hlme/Lrrk2+
Genetic Background: involves: C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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